GPR55 - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZX5

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Nov. 13, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

AM251 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 S 130 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 S 130 - G.H5 I 219 G.H5.15
Hydrophobic ICL2 P 126 - G.H5 K 216 G.H5.12
Van-der-waals ICL2 P 126 - G.H5 K 216 G.H5.12
Polar C-term V 291 - G.H5 Q 230 G.H5.26
Hydrophobic C-term V 291 - G.H5 Q 230 G.H5.26
Van-der-waals C-term V 291 - G.H5 Q 230 G.H5.26
Hydrophobic TM5 L 208 5x65 G.H5 L 220 G.H5.16
Van-der-waals C-term K 293 - G.H5 M 228 G.H5.24
Hydrophobic TM1 F 45 1x57 G.H5 M 228 G.H5.24
Van-der-waals TM1 F 45 1x57 G.H5 M 228 G.H5.24
Polar TM2 T 59 2x39 G.H5 Q 226 G.H5.22
Van-der-waals TM2 T 59 2x39 G.H5 Q 226 G.H5.22
Hydrophobic ICL1 D 55 - G.H5 Q 226 G.H5.22
Van-der-waals ICL1 D 55 - G.H5 Q 226 G.H5.22
Hydrophobic ICL3 T 215 - G.h4s6 P 194 G.h4s6.20
Van-der-waals ICL3 T 215 - G.h4s6 P 194 G.h4s6.20
Hydrophobic TM3 I 123 3x54 G.H5 L 224 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 224 G.H5.20
Polar ICL3 Q 221 - G.H5 H 221 G.H5.17
Hydrophobic ICL3 Q 221 - G.H5 H 221 G.H5.17
Van-der-waals ICL3 Q 221 - G.H5 H 221 G.H5.17
Van-der-waals ICL1 Y 56 - G.H5 K 225 G.H5.21
Hydrophobic TM6 I 228 6x37 G.H5 L 229 G.H5.25
Aromatic ICL2 H 131 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 131 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 131 - G.hns1 R 32 G.hns1.03
Polar ICL3 Q 216 - G.H4 R 184 G.H4.16
Hydrophobic ICL3 Q 216 - G.H4 R 184 G.H4.16
Van-der-waals ICL3 Q 216 - G.H4 R 184 G.H4.16
Hydrophobic ICL2 L 127 - G.H5 F 212 G.H5.08
Ionic ICL3 H 214 - G.H5 D 217 G.H5.13
Polar ICL3 H 214 - G.H5 D 217 G.H5.13
Hydrophobic ICL3 H 214 - G.H5 D 217 G.H5.13
Van-der-waals ICL3 H 214 - G.H5 D 217 G.H5.13
Polar TM6 S 227 6x36 G.H5 L 229 G.H5.25
Hydrophobic ICL2 P 126 - G.H5 L 220 G.H5.16
Van-der-waals ICL2 P 126 - G.H5 L 220 G.H5.16
Polar ICL3 Q 220 - G.H5 Q 230 G.H5.26
Hydrophobic ICL1 Y 56 - G.H5 M 228 G.H5.24
Hydrophobic TM3 R 119 3x50 G.H5 L 229 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 229 G.H5.25
Polar TM2 T 59 2x39 G.H5 L 227 G.H5.23
Hydrophobic TM2 T 59 2x39 G.H5 L 227 G.H5.23
Hydrophobic TM3 A 122 3x53 G.H5 L 227 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 L 227 G.H5.23
Hydrophobic ICL2 L 127 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 L 127 - G.H5 I 219 G.H5.15
Polar ICL3 T 215 - G.S6 L 195 G.S6.01
Hydrophobic ICL3 T 215 - G.S6 L 195 G.S6.01
Van-der-waals ICL3 T 215 - G.S6 L 195 G.S6.01
Hydrophobic ICL2 L 127 - G.H5 K 216 G.H5.12
Hydrophobic ICL3 H 214 - G.S6 Y 196 G.S6.02
Hydrophobic ICL3 R 211 - G.H5 L 220 G.H5.16
Polar ICL3 T 215 - G.H4 R 184 G.H4.16
Hydrophobic TM3 I 123 3x54 G.H5 L 229 G.H5.25
Hydrophobic ICL2 P 126 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 P 126 - G.H5 I 219 G.H5.15
Polar ICL3 Q 220 - G.H5 H 221 G.H5.17
Hydrophobic ICL3 Q 220 - G.H5 H 221 G.H5.17
Van-der-waals ICL3 Q 220 - G.H5 H 221 G.H5.17
Hydrophobic ICL3 T 215 - G.S6 Y 196 G.S6.02
Van-der-waals ICL3 T 215 - G.S6 Y 196 G.S6.02
Polar ICL2 P 126 - G.H5 N 223 G.H5.19
Hydrophobic ICL2 P 126 - G.H5 N 223 G.H5.19
Van-der-waals ICL2 P 126 - G.H5 N 223 G.H5.19
Polar TM6 C 224 6x33 G.H5 Q 230 G.H5.26
Hydrophobic TM6 C 224 6x33 G.H5 Q 230 G.H5.26
Van-der-waals TM6 C 224 6x33 G.H5 Q 230 G.H5.26
Hydrophobic TM5 L 208 5x65 G.H5 L 224 G.H5.20
Ionic ICL3 R 211 - G.H5 D 217 G.H5.13
Polar ICL3 R 211 - G.H5 D 217 G.H5.13
Hydrophobic ICL3 R 211 - G.H5 D 217 G.H5.13
Van-der-waals ICL3 R 211 - G.H5 D 217 G.H5.13
Van-der-waals TM3 I 123 3x54 G.H5 L 220 G.H5.16
Polar ICL3 Q 216 - G.h4s6 R 187 G.h4s6.08
Van-der-waals ICL3 Q 216 - G.h4s6 R 187 G.h4s6.08
Polar TM3 A 122 3x53 G.H5 N 223 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 223 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 223 G.H5.19
Hydrophobic ICL2 V 129 - G.H5 N 223 G.H5.19
Van-der-waals ICL2 V 129 - G.H5 N 223 G.H5.19
Hydrophobic TM2 T 59 2x39 G.H5 M 228 G.H5.24
Ionic ICL3 D 217 - G.H5 H 221 G.H5.17
Hydrophobic ICL3 D 217 - G.H5 H 221 G.H5.17
Van-der-waals ICL3 D 217 - G.H5 H 221 G.H5.17
Polar ICL3 Q 220 - G.h4s6 Q 191 G.h4s6.12
Hydrophobic ICL3 Q 220 - G.h4s6 Q 191 G.h4s6.12
Hydrophobic ICL3 Q 221 - G.H5 L 224 G.H5.20
Van-der-waals ICL3 Q 221 - G.H5 L 224 G.H5.20
Hydrophobic TM6 A 223 6x32 G.H5 Q 230 G.H5.26
Van-der-waals TM6 A 223 6x32 G.H5 Q 230 G.H5.26
Hydrophobic C-term I 292 - G.H5 M 228 G.H5.24
Van-der-waals C-term I 292 - G.H5 M 228 G.H5.24
Polar ICL3 Q 216 - G.h4s6 Q 190 G.h4s6.11
Van-der-waals ICL3 Q 216 - G.h4s6 Q 190 G.h4s6.11
Polar ICL2 S 130 - G.H5 N 223 G.H5.19
Van-der-waals ICL2 S 130 - G.H5 N 223 G.H5.19
Hydrophobic TM3 R 119 3x50 G.H5 L 227 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 L 227 G.H5.23
Hydrophobic TM6 C 224 6x33 G.H5 L 229 G.H5.25
Van-der-waals ICL1 D 55 - G.H5 K 225 G.H5.21
Hydrophobic ICL2 R 133 - G.H5 L 227 G.H5.23
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