GproteinDb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1499	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	3779	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	536	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.3	8.3	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	nan
	1499	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	3779	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	3779.0	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	536	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	CHEMBL434	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	DB01064	2091	None	34	Human	Functional	pEC50	=	8.1	8.1	-63	38	Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	None
	1183	3971	None	0	Human	Functional	pEC50	=	3.1	3.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	152	2	1	3	1.2	COc1cc(C=O)ccc1O	34307435
	6412	3971	None	0	Human	Functional	pEC50	=	3.1	3.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	152	2	1	3	1.2	COc1cc(C=O)ccc1O	34307435
	CHEMBL13883	3971	None	0	Human	Functional	pEC50	=	3.1	3.1	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	152	2	1	3	1.2	COc1cc(C=O)ccc1O	34307435
	12497	1572	None	60	Human	Functional	pEC50	=	3.4	3.4	-13	2	UnclassifiedUnclassified	Guide to Pharmacology	290	1	5	6	1.5	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O	21272567
	72276	1572	None	60	Human	Functional	pEC50	=	3.4	3.4	-13	2	UnclassifiedUnclassified	Guide to Pharmacology	290	1	5	6	1.5	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O	21272567
	CHEMBL583912	1572	None	60	Human	Functional	pEC50	=	3.4	3.4	-13	2	UnclassifiedUnclassified	Guide to Pharmacology	290	1	5	6	1.5	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O	21272567
	DB12039	1572	None	60	Human	Functional	pEC50	=	3.4	3.4	-13	2	UnclassifiedUnclassified	Guide to Pharmacology	290	1	5	6	1.5	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O	21272567
	12461	1574	None	55	Human	Functional	pEC50	=	3.4	3.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	306	1	6	7	1.3	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O	21272567
	72277	1574	None	55	Human	Functional	pEC50	=	3.4	3.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	306	1	6	7	1.3	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O	21272567
	CHEMBL47386	1574	None	55	Human	Functional	pEC50	=	3.4	3.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	306	1	6	7	1.3	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O	21272567
	DB03823	1574	None	55	Human	Functional	pEC50	=	3.4	3.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	306	1	6	7	1.3	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)O	21272567
	12441	3140	None	0	Human	Functional	pEC50	=	4.3	4.3	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	242	1	2	3	2.8	C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O	21942422
	382975	3140	None	0	Human	Functional	pEC50	=	4.3	4.3	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	242	1	2	3	2.8	C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O	21942422
	CHEMBL1957037	3140	None	0	Human	Functional	pEC50	=	4.3	4.3	-1	2	UnclassifiedUnclassified	Guide to Pharmacology	242	1	2	3	2.8	C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O	21942422
	2826	1784	None	76	Human	Functional	pEC50	=	4.3	4.3	-48	7	UnclassifiedUnclassified	Guide to Pharmacology	270	1	3	5	2.6	Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O	21942422
	5280961	1784	None	76	Human	Functional	pEC50	=	4.3	4.3	-48	7	UnclassifiedUnclassified	Guide to Pharmacology	270	1	3	5	2.6	Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O	21942422
	CHEMBL44	1784	None	76	Human	Functional	pEC50	=	4.3	4.3	-48	7	UnclassifiedUnclassified	Guide to Pharmacology	270	1	3	5	2.6	Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O	21942422
	DB01645	1784	None	76	Human	Functional	pEC50	=	4.3	4.3	-48	7	UnclassifiedUnclassified	Guide to Pharmacology	270	1	3	5	2.6	Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O	21942422
	12440	1326	None	0	Human	Functional	pEC50	=	4.4	4.4	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	C1=CC=C(C(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O	24117141
	5281610	1326	None	0	Human	Functional	pEC50	=	4.4	4.4	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	C1=CC=C(C(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O	24117141
	CHEMBL503168	1326	None	0	Human	Functional	pEC50	=	4.4	4.4	-4	2	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	C1=CC=C(C(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O	24117141
	4285	3110	None	68	Human	Functional	pEC50	=	4.4	4.4	-2	3	UnclassifiedUnclassified	Guide to Pharmacology	274	4	4	5	2.3	Oc1ccc(cc1)CCC(=O)c1c(O)cc(cc1O)O	24117141
	4788	3110	None	68	Human	Functional	pEC50	=	4.4	4.4	-2	3	UnclassifiedUnclassified	Guide to Pharmacology	274	4	4	5	2.3	Oc1ccc(cc1)CCC(=O)c1c(O)cc(cc1O)O	24117141
	CHEMBL45068	3110	None	68	Human	Functional	pEC50	=	4.4	4.4	-2	3	UnclassifiedUnclassified	Guide to Pharmacology	274	4	4	5	2.3	Oc1ccc(cc1)CCC(=O)c1c(O)cc(cc1O)O	24117141
	DB07810	3110	None	68	Human	Functional	pEC50	=	4.4	4.4	-2	3	UnclassifiedUnclassified	Guide to Pharmacology	274	4	4	5	2.3	Oc1ccc(cc1)CCC(=O)c1c(O)cc(cc1O)O	24117141
	12463	3563	None	0	Human	Functional	pEC50	=	4.4	4.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O	24117141
	5281697	3563	None	0	Human	Functional	pEC50	=	4.4	4.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O	24117141
	CHEMBL55415	3563	None	0	Human	Functional	pEC50	=	4.4	4.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O	24117141
	10298	2736	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	272	1	3	5	2.5	Oc1ccc(cc1)C1CC(=O)c2c(O1)cc(cc2O)O	24117141
	932	2736	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	272	1	3	5	2.5	Oc1ccc(cc1)C1CC(=O)c2c(O1)cc(cc2O)O	24117141
	CHEMBL32571	2736	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	UnclassifiedUnclassified	Guide to Pharmacology	272	1	3	5	2.5	Oc1ccc(cc1)C1CC(=O)c2c(O1)cc(cc2O)O	24117141
	107905	1573	None	57	Human	Functional	pEC50	=	4.7	4.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	442	3	7	10	2.5	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O	25273142
	12462	1573	None	57	Human	Functional	pEC50	=	4.7	4.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	442	3	7	10	2.5	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O	25273142
	CHEMBL36327	1573	None	57	Human	Functional	pEC50	=	4.7	4.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	442	3	7	10	2.5	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O	25273142
	5215	2386	None	74	Human	Functional	pEC50	=	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O	24117141
	5280445	2386	None	74	Human	Functional	pEC50	=	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O	24117141
	CHEMBL151	2386	None	74	Human	Functional	pEC50	=	5.1	5.1	-1	4	UnclassifiedUnclassified	Guide to Pharmacology	286	1	4	6	2.3	Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O	24117141
	12464	3797	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	564	2	9	12	2.2	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC4=C(C(=C(C=C4[C@@H]5[C@@H](CC6=C(C=C(C=C6O5)O)O)O)O)O)C(=O)C(=C3)O)O	25273142
	135403798	3797	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	564	2	9	12	2.2	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC4=C(C(=C(C=C4[C@@H]5[C@@H](CC6=C(C=C(C=C6O5)O)O)O)O)O)C(=O)C(=C3)O)O	25273142
	12465	3798	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology	716	4	11	16	3.2	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C4=C3C=C(C=C(C4=O)O)[C@@H]5[C@@H](CC6=C(C=C(C=C6O5)O)O)OC(=O)C7=CC(=C(C(=C7)O)O)O)O)O)O	25273142
	135458101	3798	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	UnclassifiedUnclassified	Guide to Pharmacology	716	4	11	16	3.2	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C4=C3C=C(C=C(C4=O)O)[C@@H]5[C@@H](CC6=C(C=C(C=C6O5)O)O)OC(=O)C7=CC(=C(C(=C7)O)O)O)O)O)O	25273142
	12466	163	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	236	1	0	2	3.8	CC1=CC2=C(C=C1)OC(=CC2=O)C3=CC=CC=C3	24722342
	689013	163	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	236	1	0	2	3.8	CC1=CC2=C(C=C1)OC(=CC2=O)C3=CC=CC=C3	24722342
	CHEMBL134291	163	None	0	Human	Functional	pIC50	=	4.7	4.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	236	1	0	2	3.8	CC1=CC2=C(C=C1)OC(=CC2=O)C3=CC=CC=C3	24722342

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species		Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	
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Ligand source activities (1 row/activity)