Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Assay
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

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weight		 Rot
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 DOI
23259348 170016 None 0 Human Functional pEC50 = 4.7 4.7 -1 3
Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
CHEMBL4440983 170016 None 0 Human Functional pEC50 = 4.7 4.7 -1 3
Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 100 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
68344426 175800 None 0 Human Functional pEC50 = 4.6 4.6 -3 3
Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assay
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 nan
CHEMBL4582048 175800 None 0 Human Functional pEC50 = 4.6 4.6 -3 3
Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assay
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1 nan
23259348 170016 None 0 Human Functional pEC50 = 4.6 4.6 -1 3
Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
CHEMBL4440983 170016 None 0 Human Functional pEC50 = 4.6 4.6 -1 3
Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
23259348 170016 None 0 Human Functional pEC50 = 5.6 5.6 -1 3
Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
CHEMBL4440983 170016 None 0 Human Functional pEC50 = 5.6 5.6 -1 3
Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 10 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
1499 2091 None 34 Human Functional pEC50 = 8.3 8.3 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
3779 2091 None 34 Human Functional pEC50 = 8.3 8.3 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
3779.0 2091 None 34 Human Functional pEC50 = 8.3 8.3 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
536 2091 None 34 Human Functional pEC50 = 8.3 8.3 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.3 8.3 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
DB01064 2091 None 34 Human Functional pEC50 = 8.3 8.3 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C nan
2360 3693 None 28 Human Functional pEC50 = 4.4 4.4 -19 2
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
2484 3693 None 28 Human Functional pEC50 = 4.4 4.4 -19 2
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
347 3693 None 28 Human Functional pEC50 = 4.4 4.4 -19 2
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
441071 3693 None 28 Human Functional pEC50 = 4.4 4.4 -19 2
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
CHEMBL227934 3693 None 28 Human Functional pEC50 = 4.4 4.4 -19 2
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
DB15954 3693 None 28 Human Functional pEC50 = 4.4 4.4 -19 2
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
2360 3693 None 28 Human Functional pEC50 = 5.3 5.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
2484 3693 None 28 Human Functional pEC50 = 5.3 5.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
347 3693 None 28 Human Functional pEC50 = 5.3 5.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
441071 3693 None 28 Human Functional pEC50 = 5.3 5.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
CHEMBL227934 3693 None 28 Human Functional pEC50 = 5.3 5.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
DB15954 3693 None 28 Human Functional pEC50 = 5.3 5.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 nan
23259348 170016 None 0 Human Functional pEC50 = 5.3 5.3 -1 3
Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
CHEMBL4440983 170016 None 0 Human Functional pEC50 = 5.3 5.3 -1 3
Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)Competitive-antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R10 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of strychnine-induced increase in intracellular calcium level by measuring strychnine EC50 at 30 uM by FLIPR assay (Rvb = 0.39 +/- 0.09 uM)
ChEMBL 250 0 1 3 2.6 C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1 nan
342 732 None 34 Human Functional pEC50 = 4.2 4.2 - 1
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 394 2 0 5 2.1 COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2 nan
442021 732 None 34 Human Functional pEC50 = 4.2 4.2 - 1
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 394 2 0 5 2.1 COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2 nan
CHEMBL501756 732 None 34 Human Functional pEC50 = 4.2 4.2 - 1
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 394 2 0 5 2.1 COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2 nan
12433 1365 None 6 Human Functional pEC50 = 4.2 4.2 -269 4
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 325 7 1 1 4.3 CC[N+](CC)(CC1=CC=CC=C1)CC(=O)NC2=C(C=CC=C2C)C nan
15488 1365 None 6 Human Functional pEC50 = 4.2 4.2 -269 4
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 325 7 1 1 4.3 CC[N+](CC)(CC1=CC=CC=C1)CC(=O)NC2=C(C=CC=C2C)C nan
CHEMBL1738972 1365 None 6 Human Functional pEC50 = 4.2 4.2 -269 4
Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
ChEMBL 325 7 1 1 4.3 CC[N+](CC)(CC1=CC=CC=C1)CC(=O)NC2=C(C=CC=C2C)C nan
2360 3693 None 28 Human Functional pEC50 = 8.3 8.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
Drug Central 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 None
2484 3693 None 28 Human Functional pEC50 = 8.3 8.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
Drug Central 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 None
347 3693 None 28 Human Functional pEC50 = 8.3 8.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
Drug Central 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 None
441071 3693 None 28 Human Functional pEC50 = 8.3 8.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
Drug Central 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 None
CHEMBL227934 3693 None 28 Human Functional pEC50 = 8.3 8.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
Drug Central 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 None
DB15954 3693 None 28 Human Functional pEC50 = 8.3 8.3 -19 2
Activity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assayActivity at human TAS2R10 expressed in HEK293/15 cells assessed as effect on calcium response by FLIPR assay
Drug Central 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 None
1499 2091 None 34 Human Functional pEC50 = 8.1 8.1 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
3779 2091 None 34 Human Functional pEC50 = 8.1 8.1 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
3779.0 2091 None 34 Human Functional pEC50 = 8.1 8.1 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
536 2091 None 34 Human Functional pEC50 = 8.1 8.1 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
CHEMBL434 2091 None 34 Human Functional pEC50 = 8.1 8.1 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
DB01064 2091 None 34 Human Functional pEC50 = 8.1 8.1 -63 38
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay
Drug Central 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C None
12433 1365 None 6 Human Functional pEC50 = 4.1 4.1 -269 4
UnclassifiedUnclassified
Guide to Pharmacology 325 7 1 1 4.3 CC[N+](CC)(CC1=CC=CC=C1)CC(=O)NC2=C(C=CC=C2C)C 23283334
15488 1365 None 6 Human Functional pEC50 = 4.1 4.1 -269 4
UnclassifiedUnclassified
Guide to Pharmacology 325 7 1 1 4.3 CC[N+](CC)(CC1=CC=CC=C1)CC(=O)NC2=C(C=CC=C2C)C 23283334
CHEMBL1738972 1365 None 6 Human Functional pEC50 = 4.1 4.1 -269 4
UnclassifiedUnclassified
Guide to Pharmacology 325 7 1 1 4.3 CC[N+](CC)(CC1=CC=CC=C1)CC(=O)NC2=C(C=CC=C2C)C 23283334
2360 3693 None 28 Human Functional pEC50 = 4.5 4.5 -19 2
UnclassifiedUnclassified
Guide to Pharmacology 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 20022913
2484 3693 None 28 Human Functional pEC50 = 4.5 4.5 -19 2
UnclassifiedUnclassified
Guide to Pharmacology 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 20022913
347 3693 None 28 Human Functional pEC50 = 4.5 4.5 -19 2
UnclassifiedUnclassified
Guide to Pharmacology 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 20022913
441071 3693 None 28 Human Functional pEC50 = 4.5 4.5 -19 2
UnclassifiedUnclassified
Guide to Pharmacology 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 20022913
CHEMBL227934 3693 None 28 Human Functional pEC50 = 4.5 4.5 -19 2
UnclassifiedUnclassified
Guide to Pharmacology 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 20022913
DB15954 3693 None 28 Human Functional pEC50 = 4.5 4.5 -19 2
UnclassifiedUnclassified
Guide to Pharmacology 334 0 0 3 2.1 O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3 20022913
12432 1218 None 0 Human Functional pEC50 = 5.2 5.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 558 5 3 8 3.5 CC(=O)OC(C)(C)/C=C/C(=O)[C@@](C)([C@H]1[C@@H](C[C@@]2([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)C)O)O 23283334
5281316 1218 None 0 Human Functional pEC50 = 5.2 5.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 558 5 3 8 3.5 CC(=O)OC(C)(C)/C=C/C(=O)[C@@](C)([C@H]1[C@@H](C[C@@]2([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)C)O)O 23283334
CHEMBL508185 1218 None 0 Human Functional pEC50 = 5.2 5.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 558 5 3 8 3.5 CC(=O)OC(C)(C)/C=C/C(=O)[C@@](C)([C@H]1[C@@H](C[C@@]2([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)C)O)O 23283334
12431 602 None 70 Human Functional pEC50 = 5.6 5.6 1 3
UnclassifiedUnclassified
Guide to Pharmacology 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 26501253
2355 602 None 70 Human Functional pEC50 = 5.6 5.6 1 3
UnclassifiedUnclassified
Guide to Pharmacology 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 26501253
CHEMBL24171 602 None 70 Human Functional pEC50 = 5.6 5.6 1 3
UnclassifiedUnclassified
Guide to Pharmacology 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 26501253
DB12216 602 None 70 Human Functional pEC50 = 5.6 5.6 1 3
UnclassifiedUnclassified
Guide to Pharmacology 216 1 0 4 2.5 COC1=C2C=CC(=O)OC2=CC3=C1C=CO3 26501253


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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