Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

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 DOI
16158474 213407 None 12 Human Functional pEC50 = 10.1 10.1 - 1
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
16158474.0 213407 None 12 Human Functional pEC50 = 10.1 10.1 - 1
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
CHEMBL3039582 213407 None 12 Human Functional pEC50 = 10.1 10.1 - 1
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
DB09532 213407 None 12 Human Functional pEC50 = 10.1 10.1 - 1
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
CHEMBL1256314 211124 None 0 Human Functional pEC50 = 10 10.0 - 1
Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
10356 3236 None 58 Human Functional pEC50 = 7.4 7.4 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
5284329 3236 None 58 Human Functional pEC50 = 7.4 7.4 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
CHEMBL1221984 3236 None 58 Human Functional pEC50 = 7.4 7.4 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
10356 3236 None 58 Human Functional pEC50 = 7.2 7.2 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
5284329 3236 None 58 Human Functional pEC50 = 7.2 7.2 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
CHEMBL1221984 3236 None 58 Human Functional pEC50 = 7.2 7.2 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
172442653 195117 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 563 7 2 8 7.2 O=C(O)c1cn(C2CCCCC2)c2nc(Oc3cccc4ccccc34)nc(Nc3ccc(N4CCOCC4)cc3)c12 10.1016/j.ejmech.2022.114642
CHEMBL5396976 195117 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 563 7 2 8 7.2 O=C(O)c1cn(C2CCCCC2)c2nc(Oc3cccc4ccccc34)nc(Nc3ccc(N4CCOCC4)cc3)c12 10.1016/j.ejmech.2022.114642
172468237 196888 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 561 6 1 6 9.8 c1ccc2c(Oc3nc(Nc4ccc(-c5cccc6ccccc56)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 10.1016/j.ejmech.2022.114642
CHEMBL5434238 196888 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 561 6 1 6 9.8 c1ccc2c(Oc3nc(Nc4ccc(-c5cccc6ccccc56)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 10.1016/j.ejmech.2022.114642
172460766 196191 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 536 6 2 9 6.6 Oc1ccc2c(Oc3nc(Nc4ccc(N5CCOCC5)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 10.1016/j.ejmech.2022.114642
CHEMBL5418444 196191 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 536 6 2 9 6.6 Oc1ccc2c(Oc3nc(Nc4ccc(N5CCOCC5)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 10.1016/j.ejmech.2022.114642
172460956 196427 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 536 6 2 9 6.6 Oc1cc(N2CCOCC2)ccc1Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1 10.1016/j.ejmech.2022.114642
CHEMBL5423791 196427 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 536 6 2 9 6.6 Oc1cc(N2CCOCC2)ccc1Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1 10.1016/j.ejmech.2022.114642
172448245 195651 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 527 7 1 7 8.8 c1ccc(Oc2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 10.1016/j.ejmech.2022.114642
CHEMBL5408063 195651 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 527 7 1 7 8.8 c1ccc(Oc2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 10.1016/j.ejmech.2022.114642
172463155 196665 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 536 6 2 9 5.8 O[C@@H]1CCC[C@H](n2cnc3c(Nc4ccc(N5CCOCC5)cc4)nc(Oc4cccc5ccccc45)nc32)C1 10.1016/j.ejmech.2022.114642
CHEMBL5429270 196665 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 536 6 2 9 5.8 O[C@@H]1CCC[C@H](n2cnc3c(Nc4ccc(N5CCOCC5)cc4)nc(Oc4cccc5ccccc45)nc32)C1 10.1016/j.ejmech.2022.114642
10356 3236 None 58 Human Functional pEC50 = 7.1 7.1 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
5284329 3236 None 58 Human Functional pEC50 = 7.1 7.1 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
CHEMBL1221984 3236 None 58 Human Functional pEC50 = 7.1 7.1 12 3
Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)
ChEMBL 520 6 1 8 6.9 C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 10.1016/j.ejmech.2022.114642
172466555 196778 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 511 6 1 6 8.7 c1ccc(-c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 10.1016/j.ejmech.2022.114642
CHEMBL5432045 196778 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 511 6 1 6 8.7 c1ccc(-c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 10.1016/j.ejmech.2022.114642
172444531 195503 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 534 6 2 8 7.0 OC1CCN(c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)CC1 10.1016/j.ejmech.2022.114642
CHEMBL5404963 195503 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay
ChEMBL 534 6 2 8 7.0 OC1CCN(c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)CC1 10.1016/j.ejmech.2022.114642
16158474 213407 None 12 Human Functional pEC50 = 8.0 8.0 - 1
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C None
16158474.0 213407 None 12 Human Functional pEC50 = 8.0 8.0 - 1
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C None
CHEMBL3039582 213407 None 12 Human Functional pEC50 = 8.0 8.0 - 1
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C None
DB09532 213407 None 12 Human Functional pEC50 = 8.0 8.0 - 1
NoneNone
Drug Central None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C None
1155 3572 None 0 Human Functional pEC50 = 9.7 9.7 5 7
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
16129665 3572 None 0 Human Functional pEC50 = 9.7 9.7 5 7
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
3643 3572 None 0 Human Functional pEC50 = 9.7 9.7 5 7
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
CHEMBL1201488 3572 None 0 Human Functional pEC50 = 9.7 9.7 5 7
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
DB00021 3572 None 0 Human Functional pEC50 = 9.7 9.7 5 7
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7612008
1152 3995 None 15 Human Functional pIC50 = 5.4 5.4 -3090 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
16129679 3995 None 15 Human Functional pIC50 = 5.4 5.4 -3090 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
53395115 3995 None 15 Human Functional pIC50 = 5.4 5.4 -3090 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
91898389 3995 None 15 Human Functional pIC50 = 5.4 5.4 -3090 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
CHEMBL1981592 3995 None 15 Human Functional pIC50 = 5.4 5.4 -3090 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
1156 3575 None 0 Rat Functional pIC50 None 5 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
CHEMBL1256314 211124 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
16158474 213407 None 12 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
16158474.0 213407 None 12 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
CHEMBL3039582 213407 None 12 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
DB09532 213407 None 12 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C 10.1016/j.bmcl.2010.08.062
1152 3995 None 15 Rat Binding pIC50 = 6.2 6.2 - 4
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129679 3995 None 15 Rat Binding pIC50 = 6.2 6.2 - 4
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
53395115 3995 None 15 Rat Binding pIC50 = 6.2 6.2 - 4
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
91898389 3995 None 15 Rat Binding pIC50 = 6.2 6.2 - 4
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1981592 3995 None 15 Rat Binding pIC50 = 6.2 6.2 - 4
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3293 468 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
1155 3572 None 0 Rat Binding pIC50 = 9 9.0 3162 2
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129665 3572 None 0 Rat Binding pIC50 = 9 9.0 3162 2
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3643 3572 None 0 Rat Binding pIC50 = 9 9.0 3162 2
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1201488 3572 None 0 Rat Binding pIC50 = 9 9.0 3162 2
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
DB00021 3572 None 0 Rat Binding pIC50 = 9 9.0 3162 2
Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3755 924 None 0 Human Binding pKi = 5.3 5.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702423
1155 3572 None 0 Rat Binding pKi = 8.5 8.5 3162 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
16129665 3572 None 0 Rat Binding pKi = 8.5 8.5 3162 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
3643 3572 None 0 Rat Binding pKi = 8.5 8.5 3162 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
CHEMBL1201488 3572 None 0 Rat Binding pKi = 8.5 8.5 3162 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
DB00021 3572 None 0 Rat Binding pKi = 8.5 8.5 3162 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1646711
2943 3573 None 0 Rat Binding pKi = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10383421
2943 3573 None 0 Rat Binding pKi = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9694908
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