GproteinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	122653602	184933	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	CHEMBL4852000	184933	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	122653721	184504	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4845846	184504	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653713	184539	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846330	184539	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653650	184540	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4846333	184540	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653704	184544	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4846416	184544	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653665	184558	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846586	184558	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653719	184568	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846775	184568	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	122653649	184574	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4846914	184574	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653642	184582	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846977	184582	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653806	184627	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4847685	184627	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653408	184629	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847708	184629	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653470	184633	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847735	184633	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653679	184666	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	CHEMBL4848378	184666	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	122653688	184667	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4848379	184667	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653654	184686	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4848606	184686	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653571	184695	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4848812	184695	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653464	184718	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4849056	184718	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653683	184731	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	CHEMBL4849398	184731	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	122653417	184756	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849645	184756	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653491	184761	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	CHEMBL4849698	184761	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	122653696	184780	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	CHEMBL4849904	184780	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	122653579	184785	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849970	184785	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653601	184794	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850054	184794	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653613	184832	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	CHEMBL4850541	184832	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	122653676	184851	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850812	184851	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653686	184862	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4850965	184862	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653731	184869	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	CHEMBL4851069	184869	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	122653592	184888	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4851368	184888	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653436	184889	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4851394	184889	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653690	184895	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4851533	184895	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653558	184896	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4851577	184896	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653573	184915	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4851800	184915	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653608	184925	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	CHEMBL4851936	184925	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	122653448	184947	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4852273	184947	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653452	184953	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4852339	184953	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653453	184960	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4852404	184960	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653427	184986	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	CHEMBL4852734	184986	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	122653420	185011	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853193	185011	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654155	185029	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853351	185029	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653581	185042	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4853555	185042	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653658	185043	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853557	185043	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653641	185051	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	CHEMBL4853689	185051	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	122653547	185061	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4853824	185061	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653619	185068	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4853939	185068	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653645	185080	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854092	185080	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653725	185082	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854146	185082	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653537	185085	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	CHEMBL4854218	185085	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	122653488	185112	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4854701	185112	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653599	185118	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	CHEMBL4854849	185118	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	122653722	185134	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4855055	185134	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653455	185138	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855110	185138	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653627	185148	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4855290	185148	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653632	185164	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855414	185164	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653486	185175	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4855646	185175	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653810	185185	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	CHEMBL4855829	185185	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	122653618	185195	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856011	185195	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609725	185203	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856051	185203	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609750	185229	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856315	185229	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164614108	185237	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856557	185237	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164614116	185242	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4856676	185242	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653723	185249	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4856786	185249	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653607	185254	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856937	185254	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653609	185337	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4858042	185337	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653629	185338	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4858047	185338	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653504	185344	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4858187	185344	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653540	185351	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858311	185351	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653412	185360	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858448	185360	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653473	185368	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858574	185368	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653489	185432	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4859593	185432	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653708	185452	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860064	185452	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653667	185465	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4860274	185465	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653407	185468	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860294	185468	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653481	185521	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	CHEMBL4861199	185521	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	122653808	185540	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4861454	185540	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653426	185569	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	CHEMBL4861879	185569	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	122653405	185575	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4861950	185575	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653749	185612	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862500	185612	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653745	185617	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	CHEMBL4862529	185617	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	122653500	185654	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4863091	185654	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653416	185659	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863198	185659	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653669	185679	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863386	185679	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653624	185684	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	CHEMBL4863447	185684	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	122653435	185690	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	CHEMBL4863562	185690	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	122653567	185691	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863576	185691	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653804	185693	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4863613	185693	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653543	185698	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863658	185698	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653554	185711	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863892	185711	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653694	185721	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4864049	185721	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653480	185743	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4864397	185743	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653747	185749	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4864476	185749	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653506	185776	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864933	185776	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653610	185783	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4865057	185783	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653750	185788	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	CHEMBL4865124	185788	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	122653520	185789	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4865128	185789	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653728	185818	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865653	185818	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653434	185829	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865786	185829	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653569	185834	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	CHEMBL4865910	185834	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	122653712	185839	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	CHEMBL4865996	185839	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	122653803	185849	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866193	185849	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653465	185871	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	CHEMBL4866434	185871	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	122653620	185874	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866463	185874	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653724	185881	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4866543	185881	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653706	185888	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4866626	185888	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122660774	185895	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4866746	185895	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	122653748	185902	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4866874	185902	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653717	185916	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4867044	185916	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653680	185955	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4867659	185955	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653626	185956	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4867681	185956	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653477	185984	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868214	185984	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653697	186002	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	CHEMBL4868562	186002	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	122653462	186007	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868643	186007	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653545	186015	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	CHEMBL4868799	186015	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	122653419	186023	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	CHEMBL4868949	186023	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	122653460	186024	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4869015	186024	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653519	186027	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4869072	186027	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653693	186032	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869130	186032	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653518	186033	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4869139	186033	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653692	186042	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4869262	186042	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653691	186044	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869305	186044	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653630	186055	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869524	186055	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653483	186088	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4869851	186088	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653648	186092	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4870024	186092	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653406	186093	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	CHEMBL4870029	186093	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	122653709	186146	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4870751	186146	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653458	186153	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870894	186153	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653638	186155	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870900	186155	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653428	186166	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4871052	186166	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	122653751	186180	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	CHEMBL4871344	186180	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	122653586	186238	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871971	186238	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653589	186244	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4872112	186244	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653461	186250	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872227	186250	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653597	186260	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872358	186260	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122660773	186364	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4873801	186364	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	122653482	186365	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4873808	186365	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653628	186380	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874029	186380	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653590	186419	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874627	186419	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653603	186455	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4875102	186455	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653521	186458	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875163	186458	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164629075	186466	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4875342	186466	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653698	186472	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4875443	186472	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653514	186485	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875637	186485	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654150	186520	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	CHEMBL4876057	186520	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	122653705	186523	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4876095	186523	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653595	186537	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	CHEMBL4876282	186537	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	122653585	186554	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4876504	186554	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653634	186582	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4876839	186582	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653720	186604	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4877278	186604	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653695	186605	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877331	186605	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653677	186615	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4877494	186615	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653672	186618	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4877524	186618	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653640	186635	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4877713	186635	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653538	186647	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4877909	186647	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653534	186663	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4878069	186663	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653451	186666	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878142	186666	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653510	186672	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4878221	186672	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653549	186692	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	CHEMBL4878529	186692	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	122653729	186701	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878629	186701	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653583	186728	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4879330	186728	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653714	186008	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868685	186008	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653423	185646	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4862971	185646	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653512	186257	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	CHEMBL4872333	186257	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	162676039	183569	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799062	183569	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	162662654	181999	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779158	181999	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653659	184652	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4848041	184652	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	162659079	181389	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4762205	181389	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162663893	182112	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780640	182112	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	54670455	155889	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4059658	155889	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653588	185291	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857429	185291	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653600	185793	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4865212	185793	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	137640725	157123	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4073584	157123	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	162644528	179496	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4739868	179496	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655320	180820	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755625	180820	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653730	180287	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4749272	180287	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	122653687	185641	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862838	185641	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653670	185621	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862614	185621	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653730	180287	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4749272	180287	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653499	186172	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	CHEMBL4871179	186172	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	137654783	158970	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4095110	158970	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162655975	180891	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4756386	180891	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	155977949	182115	None	20	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780654	182115	None	20	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137659986	159308	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	CHEMBL4098770	159308	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	56649300	157863	None	30	Mouse	Functional	pEC50	=	6.9	6.9	-1	3	CHO-based cAMP assay (mouse)CHO-based cAMP assay (mouse)	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	CHEMBL4082756	157863	None	30	Mouse	Functional	pEC50	=	6.9	6.9	-1	3	CHO-based cAMP assay (mouse)CHO-based cAMP assay (mouse)	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	122653605	186617	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877497	186617	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	69921128	165165	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	CHEMBL4226751	165165	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	69921041	165314	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4229063	165314	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162660100	181334	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761453	181334	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	162660762	181363	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761816	181363	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	122653655	186482	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	CHEMBL4875581	186482	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	137647647	157744	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4081439	157744	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	162652816	180483	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751676	180483	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	70922254	165160	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226695	165160	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	122653422	186061	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	CHEMBL4869553	186061	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	137635271	156115	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4062229	156115	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653459	184516	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846042	184516	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653726	185720	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	CHEMBL4864048	185720	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	122653449	184655	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4848165	184655	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162656501	181001	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4757616	181001	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	59193825	112479	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	CHEMBL3297807	112479	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	69921479	1371	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	9804	1371	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	CHEMBL4228912	1371	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	122653611	185279	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857269	185279	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122654148	185199	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4856037	185199	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	137637645	156313	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4064577	156313	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653689	185623	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	CHEMBL4862638	185623	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	137644761	158583	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	CHEMBL4091030	158583	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	122653437	184786	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4849975	184786	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	56651044	158238	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4087237	158238	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653604	186187	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	CHEMBL4871459	186187	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	122653668	185485	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	CHEMBL4860543	185485	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	162662725	182000	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779168	182000	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137649487	157293	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4075971	157293	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	137639427	156874	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4070849	156874	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162644756	179548	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4740473	179548	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	44623954	1136	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	8840	1136	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	CHEMBL3299119	1136	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	59193920	112508	None	9	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298233	112508	None	9	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	122653478	184615	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847442	184615	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162665315	182353	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4783576	182353	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	122653639	184733	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	CHEMBL4849417	184733	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	122653746	186597	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877187	186597	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653653	184839	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4850677	184839	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653556	186310	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4873066	186310	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162654687	180706	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754435	180706	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	162675088	183423	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797286	183423	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162674993	183477	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797830	183477	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	59193747	112601	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	CHEMBL3299120	112601	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	162655237	180815	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755614	180815	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653637	186167	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	CHEMBL4871096	186167	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	162672139	183021	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4792434	183021	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653507	186324	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4873264	186324	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653498	185935	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	CHEMBL4867455	185935	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	122653457	185176	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855685	185176	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	59194084	112603	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3299122	112603	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	137639301	157047	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4072782	157047	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	162652119	180449	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751311	180449	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162677433	183617	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799772	183617	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	122653552	185974	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868031	185974	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	59193882	112602	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299121	112602	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	122653447	186559	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	CHEMBL4876570	186559	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	59193828	112604	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299123	112604	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	137648436	157970	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4083957	157970	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	137648989	157201	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4074656	157201	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162654874	180694	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754346	180694	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655610	180843	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755935	180843	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	137659770	159376	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	CHEMBL4099457	159376	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	67185105	112482	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297811	112482	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653539	185260	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4857044	185260	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	162647123	179633	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741318	179633	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921111	165289	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4228734	165289	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162649639	180187	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4748048	180187	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921074	165137	None	1	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4226295	165137	None	1	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	122653454	184649	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4847995	184649	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653710	185561	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	CHEMBL4861734	185561	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	122653718	185583	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4862064	185583	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	59193981	112481	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297810	112481	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653716	186234	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871931	186234	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162668388	182860	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4790115	182860	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162665062	182184	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4781520	182184	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162656735	180956	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	CHEMBL4757171	180956	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	137661708	159563	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4101517	159563	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653471	185739	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864354	185739	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653560	185920	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4867123	185920	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653474	186515	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	CHEMBL4876029	186515	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	122653651	185206	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	CHEMBL4856067	185206	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	70922218	165134	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226253	165134	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921013	165164	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226750	165164	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	59193856	112605	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	CHEMBL3299124	112605	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	59193730	112606	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	CHEMBL3299125	112606	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	162659255	181338	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	CHEMBL4761550	181338	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	137653669	158657	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4091718	158657	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653555	186213	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4871721	186213	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	162662957	182025	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779620	182025	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	122653438	185628	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862739	185628	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	54670452	157678	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4080724	157678	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	56649300	157863	None	30	Human	Functional	pEC50	=	7.1	7.1	1	3	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4082756	157863	None	30	Human	Functional	pEC50	=	7.1	7.1	1	3	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162670049	182812	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	CHEMBL4789517	182812	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	162668520	182739	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	CHEMBL4788591	182739	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	122653533	186052	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	CHEMBL4869490	186052	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	118798887	186354	None	20	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4873666	186354	None	20	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653606	184616	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	CHEMBL4847476	184616	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	59193906	112480	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	CHEMBL3297809	112480	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	137660928	159394	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4099668	159394	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	44816186	112509	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298234	112509	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	162647487	180051	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4746394	180051	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	70922568	165132	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226225	165132	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921357	165320	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	CHEMBL4229128	165320	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	122653711	185522	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4861218	185522	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653542	186020	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4868910	186020	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162659193	181328	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761381	181328	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	56649300	157863	None	30	Human	Functional	pEC50	=	7.0	7.0	1	3	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5209897
	CHEMBL4082756	157863	None	30	Human	Functional	pEC50	=	7.0	7.0	1	3	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5209897
	56649300	157863	None	30	Human	Functional	pEC50	=	7.0	7.0	1	3	CHO-based cAMP assay (human)CHO-based cAMP assay (human)	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	CHEMBL4082756	157863	None	30	Human	Functional	pEC50	=	7.0	7.0	1	3	CHO-based cAMP assay (human)CHO-based cAMP assay (human)	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	162645603	179616	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741200	179616	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653404	186385	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4874102	186385	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	162671742	182911	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4790746	182911	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	162664350	182275	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782590	182275	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162646497	179624	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4741257	179624	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	162676088	183429	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4797370	183429	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162669764	182674	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4787771	182674	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	162648761	180059	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746541	180059	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162670773	183087	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4793323	183087	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162673688	183262	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	CHEMBL4795327	183262	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	162659243	181312	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761208	181312	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162672248	182976	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4791780	182976	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	162649157	179946	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	CHEMBL4745132	179946	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	162664011	182311	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4783011	182311	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	162659388	181296	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761078	181296	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162648653	180014	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746014	180014	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162661330	181506	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4763588	181506	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162644983	179566	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4740701	179566	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162650192	180248	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	CHEMBL4748854	180248	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	58517179	181881	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4777734	181881	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	162660152	181442	None	0	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4762863	181442	None	0	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	5316932	91578	None	20	Human	Functional	pIC50	=	5.3	5.3	1	2	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL240484	91578	None	20	Human	Functional	pIC50	=	5.3	5.3	1	2	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	5316932	91578	None	20	Mouse	Functional	pIC50	=	5.2	5.2	-1	2	In-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levelsIn-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levels	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c02235
	CHEMBL240484	91578	None	20	Mouse	Functional	pIC50	=	5.2	5.2	-1	2	In-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levelsIn-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levels	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c02235
	162662933	182120	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	CHEMBL4780703	182120	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	156588927	182254	None	23	Mouse	Functional	pIC50	=	6.2	6.2	1	2	In-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levelsIn-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levels	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c02235
	CHEMBL4782344	182254	None	23	Mouse	Functional	pIC50	=	6.2	6.2	1	2	In-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levelsIn-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levels	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c02235
	10879121	89657	None	15	Human	Functional	pIC50	=	6.2	6.2	1	2	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL2375494	89657	None	15	Human	Functional	pIC50	=	6.2	6.2	1	2	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	10879121	89657	None	15	Mouse	Functional	pIC50	=	6.2	6.2	-1	2	In-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levelsIn-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levels	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c02235
	CHEMBL2375494	89657	None	15	Mouse	Functional	pIC50	=	6.2	6.2	-1	2	In-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levelsIn-vivo antagonist activity at GPR52 in HdhQ140 mouse model with GPR52 knockdown assessed as decrease in mHTT levels	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c02235
	162675641	183502	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4798117	183502	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162656078	180793	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4755423	180793	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	156588927	182254	None	23	Human	Functional	pIC50	=	6.1	6.1	-1	2	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782344	182254	None	23	Human	Functional	pIC50	=	6.1	6.1	-1	2	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	162675368	183399	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4796964	183399	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	44623954	1136	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	8840	1136	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	CHEMBL3299119	1136	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	69921479	1371	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	9804	1371	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	CHEMBL4228912	1371	None	2	Human	Functional	pEC50	=	7.7	7.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	156735309	194251	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2cncc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	CHEMBL5282094	194251	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2cncc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	156735541	194478	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
	CHEMBL5287006	194478	None	0	Human	Binding	pEC50	=	8	8.0	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
	156735292	194182	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cncc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5280513	194182	None	0	Human	Binding	pEC50	=	7	7.0	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cncc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	156735648	194584	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	389	3	1	3	3.9	O=C1NCCc2c1cnn2-c1cccc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5289682	194584	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	389	3	1	3	3.9	O=C1NCCc2c1cnn2-c1cccc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	156735572	194510	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	4	1	4	3.2	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5287950	194510	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	4	1	4	3.2	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	156735464	194058	None	0	Human	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	386	4	1	4	3.5	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	CHEMBL5277794	194058	None	0	Human	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	386	4	1	4	3.5	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	156735279	193901	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	0	4	3.6	CN1CCc2c(cnn2-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)ccn2)C1=O	10.1021/acsmedchemlett.3c00052
	CHEMBL5274093	193901	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	0	4	3.6	CN1CCc2c(cnn2-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)ccn2)C1=O	10.1021/acsmedchemlett.3c00052
	171347738	194374	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	371	3	0	4	4.4	O=C1CCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
	CHEMBL5284809	194374	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	371	3	0	4	4.4	O=C1CCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
	156735268	193817	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	376	3	1	4	3.3	O=C1NCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5272124	193817	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	376	3	1	4	3.3	O=C1NCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	156735500	194360	None	8	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5284353	194360	None	8	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	156735265	194095	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	CHEMBL5278598	194095	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	156735500	194360	None	8	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5284353	194360	None	8	Human	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	90645439	112600	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
	CHEMBL3299118	112600	None	0	Human	Binding	pEC50	=	6.5	6.5	-	0	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
	156735485	194081	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	424	3	1	4	4.0	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)c(Cl)c(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5278255	194081	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	424	3	1	4	4.0	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)c(Cl)c(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	156735329	193894	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.7	O=C1NCCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5273936	193894	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.7	O=C1NCCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	156735482	194634	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2nn(-c3ccnc(Cc4cc(F)cc(C(F)(F)F)c4)c3)cc21	10.1021/acsmedchemlett.3c00052
	CHEMBL5291296	194634	None	0	Human	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2nn(-c3ccnc(Cc4cc(F)cc(C(F)(F)F)c4)c3)cc21	10.1021/acsmedchemlett.3c00052
	156735504	194488	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	402	5	1	5	3.2	Cc1nn(-c2ccnc(Cc3cc(F)cc(OC(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	CHEMBL5287320	194488	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	402	5	1	5	3.2	Cc1nn(-c2ccnc(Cc3cc(F)cc(OC(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
	156735352	193811	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	3	1	4	3.2	O=C1NCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
	CHEMBL5271921	193811	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	3	1	4	3.2	O=C1NCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
	156735378	193611	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	391	3	1	5	2.7	O=C1NCCc2c1nnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	CHEMBL5267002	193611	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	391	3	1	5	2.7	O=C1NCCc2c1nnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
	44206579	112599	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
	CHEMBL3299117	112599	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
	56649300	157863	None	30	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4082756	157863	None	30	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	56649300	157863	None	30	Human	Binding	pEC50	=	7.0	7.0	-	0	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5210121
	CHEMBL4082756	157863	None	30	Human	Binding	pEC50	=	7.0	7.0	-	0	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5210121
	171353011	194120	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	372	2	0	6	2.9	C=C1C(=O)O[C@@H]2C/C=C(\C)CC3C=C(C[C@H](OC(=O)/C(C)=C\C)[C@@H]12)C(=O)O3	10.1021/acs.jmedchem.2c00799
	CHEMBL5279049	194120	None	0	Human	Binding	pIC50	=	4.9	4.9	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	372	2	0	6	2.9	C=C1C(=O)O[C@@H]2C/C=C(\C)CC3C=C(C[C@H](OC(=O)/C(C)=C\C)[C@@H]12)C(=O)O3	10.1021/acs.jmedchem.2c00799
	5316932	91578	None	20	Human	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.2c00799
	CHEMBL240484	91578	None	20	Human	Binding	pIC50	=	5.3	5.3	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.2c00799
	156588927	182254	None	23	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.2c00799
	CHEMBL4782344	182254	None	23	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.2c00799
	10879121	89657	None	15	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.2c00799
	CHEMBL2375494	89657	None	15	Human	Binding	pIC50	=	6.2	6.2	-	0	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.2c00799

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Main reference

Ligand source activities (1 row/activity)