Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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ID		 Reference
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 Assay
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

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 DOI
137642920 158207 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 390 7 1 3 5.5 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4086893 158207 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 390 7 1 3 5.5 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 10.1016/j.bmcl.2017.01.034
134157586 154252 None 0 Human Functional pEC50 = 7 7.0 -3 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 366 8 1 3 5.5 O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3985509 154252 None 0 Human Functional pEC50 = 7 7.0 -3 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 366 8 1 3 5.5 O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
90407037 157380 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 377 8 1 3 5.3 CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4076902 157380 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 377 8 1 3 5.3 CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
90405670 164789 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 425 7 1 3 5.4 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4217143 164789 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 425 7 1 3 5.4 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2018.02.013
118707082 113071 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 309 4 1 3 3.3 COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311196 113071 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 309 4 1 3 3.3 COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1 10.1016/j.bmcl.2014.05.012
925016 113093 None 13 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 289 3 1 2 3.7 Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311314 113093 None 13 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 289 3 1 2 3.7 Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
137649416 157611 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4079893 157611 None 0 Human Functional pEC50 = 6 6.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2017.01.034
82051616 159551 None 0 Human Functional pEC50 = 6 6.0 12 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl 10.1016/j.bmcl.2017.01.034
CHEMBL4101323 159551 None 0 Human Functional pEC50 = 6 6.0 12 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl 10.1016/j.bmcl.2017.01.034
975397 113099 None 6 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 335 5 1 4 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC 10.1016/j.bmcl.2014.05.012
CHEMBL3311324 113099 None 6 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 335 5 1 4 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC 10.1016/j.bmcl.2014.05.012
137634844 156207 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 412 9 1 3 6.1 CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4063239 156207 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 412 9 1 3 6.1 CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
137640323 157070 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 358 7 1 4 4.3 O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
CHEMBL4073013 157070 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 358 7 1 4 4.3 O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
137653973 158776 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 354 6 2 3 4.3 Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O 10.1016/j.bmcl.2017.01.034
CHEMBL4093067 158776 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 354 6 2 3 4.3 Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O 10.1016/j.bmcl.2017.01.034
134133275 143730 None 0 Human Functional pEC50 = 7.0 7.0 -8 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 5 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3899885 143730 None 0 Human Functional pEC50 = 7.0 7.0 -8 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 5 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 10.1016/j.bmcl.2016.10.054
85472225 162856 None 0 Mouse Functional pEC50 = 7.0 7.0 -2 3
Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4171724 162856 None 0 Mouse Functional pEC50 = 7.0 7.0 -2 3
Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
134133797 143655 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 338 3 0 4 3.6 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3899190 143655 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 338 3 0 4 3.6 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
85472621 162898 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4172392 162898 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
145955668 162520 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 415 7 1 4 6.0 Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL4166208 162520 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 415 7 1 4 6.0 Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1021/acsmedchemlett.7b00233
134149615 148664 None 0 Mouse Functional pEC50 = 7.0 7.0 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
CHEMBL3939004 148664 None 0 Mouse Functional pEC50 = 7.0 7.0 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
137640701 157181 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 427 9 1 4 6.2 CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4074388 157181 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 427 9 1 4 6.2 CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
137636217 156184 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 425 8 1 4 6.1 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4063013 156184 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 425 8 1 4 6.1 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C 10.1016/j.bmcl.2017.06.028
137642920 158207 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 390 7 1 3 5.5 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4086893 158207 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 390 7 1 3 5.5 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 10.1016/j.bmcl.2017.01.034
90418476 162881 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 511 7 1 4 6.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4172136 162881 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 511 7 1 4 6.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
57521919 76304 None 0 Human Functional pEC50 = 7.0 7.0 23 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 10.1021/jm300215x
CHEMBL2058532 76304 None 0 Human Functional pEC50 = 7.0 7.0 23 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 10.1021/jm300215x
CHEMBL4207911 76304 None 0 Human Functional pEC50 = 7.0 7.0 23 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 10.1021/jm300215x
137636217 156184 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 425 8 1 4 6.1 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4063013 156184 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 425 8 1 4 6.1 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C 10.1016/j.bmcl.2017.06.028
134138099 147910 None 0 Human Functional pEC50 = 6.0 6.0 4 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 369 3 0 3 4.6 Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3932897 147910 None 0 Human Functional pEC50 = 6.0 6.0 4 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 369 3 0 3 4.6 Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
60195036 81752 None 0 Human Functional pEC50 = 5.0 5.0 -630 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 481 12 2 5 5.1 Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 10.1021/jm3002026
CHEMBL2163924 81752 None 0 Human Functional pEC50 = 5.0 5.0 -630 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 481 12 2 5 5.1 Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 10.1021/jm3002026
137632299 156558 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 455 7 1 4 5.8 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4067368 156558 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 455 7 1 4 5.8 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
90406631 164529 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 503 7 1 3 6.1 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4213709 164529 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 503 7 1 3 6.1 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
137643228 158348 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 457 8 1 5 5.2 COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4088620 158348 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 457 8 1 5 5.2 COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
137647721 157922 None 0 Human Functional pEC50 = 4.9 4.9 1 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.5 CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
CHEMBL4083440 157922 None 0 Human Functional pEC50 = 4.9 4.9 1 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.5 CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
59455584 157133 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 378 8 1 4 4.6 CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4073815 157133 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 378 8 1 4 4.6 CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
90406228 163797 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 453 8 1 3 5.9 CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2018.02.013
CHEMBL4204928 163797 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 453 8 1 3 5.9 CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2018.02.013
561372 58844 None 46 Human Functional pEC50 = 4.9 4.9 -20 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 256 6 1 2 3.3 O=C(O)CCc1ccc(OCc2ccccc2)cc1 10.1021/jm300215x
CHEMBL1688452 58844 None 46 Human Functional pEC50 = 4.9 4.9 -20 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 256 6 1 2 3.3 O=C(O)CCc1ccc(OCc2ccccc2)cc1 10.1021/jm300215x
11717831 585 None 42 Human Functional pEC50 = 5.9 5.9 -38 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 379 7 2 7 2.4 N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N 10.6019/CHEMBL5442687
3289 585 None 42 Human Functional pEC50 = 5.9 5.9 -38 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 379 7 2 7 2.4 N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N 10.6019/CHEMBL5442687
CHEMBL4202825 585 None 42 Human Functional pEC50 = 5.9 5.9 -38 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 379 7 2 7 2.4 N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N 10.6019/CHEMBL5442687
86343591 163798 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 457 7 1 3 5.8 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4204946 163798 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 457 7 1 3 5.8 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1 10.1016/j.bmcl.2018.02.013
134133275 143730 None 0 Mouse Functional pEC50 = 7.9 7.9 8 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 5 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3899885 143730 None 0 Mouse Functional pEC50 = 7.9 7.9 8 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 5 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 10.1016/j.bmcl.2016.10.054
137643958 158371 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 505 7 1 4 6.0 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4088889 158371 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 505 7 1 4 6.0 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
137657488 159774 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 441 7 1 4 5.5 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4104082 159774 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 441 7 1 4 5.5 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
90418753 162491 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 463 8 1 4 6.6 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4165803 162491 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 463 8 1 4 6.6 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
73777111 149798 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3947837 149798 None 0 Human Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
25098573 2747 None 10 Human Functional pEC50 = 5.9 5.9 8 2
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 10.1021/jm800970b
5587 2747 None 10 Human Functional pEC50 = 5.9 5.9 8 2
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 10.1021/jm800970b
CHEMBL463785 2747 None 10 Human Functional pEC50 = 5.9 5.9 8 2
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 10.1021/jm800970b
134141270 146898 None 0 Human Functional pEC50 = 6.9 6.9 -3 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 334 8 1 3 4.6 CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3924759 146898 None 0 Human Functional pEC50 = 6.9 6.9 -3 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 334 8 1 3 4.6 CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
90418849 162791 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 473 7 1 4 6.5 Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O 10.1021/acsmedchemlett.7b00233
CHEMBL4170501 162791 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 473 7 1 4 6.5 Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O 10.1021/acsmedchemlett.7b00233
11316919 3068 None 31 Human Functional pEC50 = 5.9 5.9 -2 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 451 4 0 4 5.3 Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F 10.6019/CHEMBL5442687
11693 3068 None 31 Human Functional pEC50 = 5.9 5.9 -2 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 451 4 0 4 5.3 Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F 10.6019/CHEMBL5442687
CHEMBL484929 3068 None 31 Human Functional pEC50 = 5.9 5.9 -2 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 451 4 0 4 5.3 Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F 10.6019/CHEMBL5442687
8190724 113092 None 5 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 359 4 1 3 4.3 Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311313 113092 None 5 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 359 4 1 3 4.3 Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
258072 80119 None 21 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 275 3 1 2 3.4 Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL2131154 80119 None 21 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 275 3 1 2 3.4 Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1 10.1016/j.bmcl.2014.05.012
91824000 113091 None 6 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311312 113091 None 6 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1 10.1016/j.bmcl.2014.05.012
137647721 157922 None 0 Human Functional pEC50 = 4.9 4.9 1 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.5 CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
CHEMBL4083440 157922 None 0 Human Functional pEC50 = 4.9 4.9 1 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.5 CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
57521919 76304 None 0 Human Functional pEC50 = 6.9 6.9 23 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 10.1016/j.bmc.2017.10.040
CHEMBL2058532 76304 None 0 Human Functional pEC50 = 6.9 6.9 23 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 10.1016/j.bmc.2017.10.040
CHEMBL4207911 76304 None 0 Human Functional pEC50 = 6.9 6.9 23 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 10.1016/j.bmc.2017.10.040
54586011 61828 None 0 Human Functional pEC50 = 5.9 5.9 -14 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 324 6 1 2 4.3 O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1 10.1021/jm300215x
CHEMBL1773257 61828 None 0 Human Functional pEC50 = 5.9 5.9 -14 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 324 6 1 2 4.3 O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1 10.1021/jm300215x
137640701 157181 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 427 9 1 4 6.2 CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4074388 157181 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 427 9 1 4 6.2 CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
134151903 153445 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 438 6 1 6 4.2 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3978465 153445 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 438 6 1 6 4.2 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
73777069 142756 None 0 Human Functional pEC50 = 6.9 6.9 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3891920 142756 None 0 Human Functional pEC50 = 6.9 6.9 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
73777174 150542 None 0 Mouse Functional pEC50 = 5.9 5.9 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3954140 150542 None 0 Mouse Functional pEC50 = 5.9 5.9 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
11498 3019 None 34 Human Functional pEC50 = 5.9 5.9 -18 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 392 3 1 5 4.1 CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC 10.6019/CHEMBL5442687
4995951 3019 None 34 Human Functional pEC50 = 5.9 5.9 -18 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 392 3 1 5 4.1 CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC 10.6019/CHEMBL5442687
CHEMBL59898 3019 None 34 Human Functional pEC50 = 5.9 5.9 -18 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 392 3 1 5 4.1 CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC 10.6019/CHEMBL5442687
134136175 142767 None 0 Mouse Functional pEC50 = 6.9 6.9 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3892019 142767 None 0 Mouse Functional pEC50 = 6.9 6.9 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
643684 107571 None 40 Human Functional pEC50 = 5.9 5.9 8 2
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 298 15 2 2 5.1 CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O 10.1039/C7MD00130D
CHEMBL3186422 107571 None 40 Human Functional pEC50 = 5.9 5.9 8 2
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 298 15 2 2 5.1 CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O 10.1039/C7MD00130D
86343965 163906 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 443 7 1 3 5.5 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4206168 163906 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 443 7 1 3 5.5 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
90418650 157447 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4077787 157447 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
85470884 164099 None 3 Human Functional pEC50 = 6.9 6.9 2 5
Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4208325 164099 None 3 Human Functional pEC50 = 6.9 6.9 2 5
Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
134149615 148664 None 0 Human Functional pEC50 = 6.9 6.9 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
CHEMBL3939004 148664 None 0 Human Functional pEC50 = 6.9 6.9 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
90406583 164756 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 416 7 1 4 4.9 N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F 10.1016/j.bmcl.2018.02.013
CHEMBL4216721 164756 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 416 7 1 4 4.9 N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F 10.1016/j.bmcl.2018.02.013
134144000 150297 None 0 Human Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3952043 150297 None 0 Human Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
134154415 152783 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 447 6 1 5 6.3 Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 10.1021/acsmedchemlett.6b00394
CHEMBL3972870 152783 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 447 6 1 5 6.3 Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 10.1021/acsmedchemlett.6b00394
137640328 157076 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F 10.1016/j.bmcl.2017.06.028
CHEMBL4073078 157076 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F 10.1016/j.bmcl.2017.06.028
134133675 143349 None 0 Mouse Functional pEC50 = 6.9 6.9 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 318 8 1 3 4.1 CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3896714 143349 None 0 Mouse Functional pEC50 = 6.9 6.9 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 318 8 1 3 4.1 CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
1050 1902 None 58 Human Functional pEC50 = 5.9 5.9 -26 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1021/jm300215x
11595431 1902 None 58 Human Functional pEC50 = 5.9 5.9 -26 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1021/jm300215x
CHEMBL207881 1902 None 58 Human Functional pEC50 = 5.9 5.9 -26 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1021/jm300215x
85471695 158761 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4092882 158761 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
57522038 3887 None 48 Human Functional pEC50 = 5.9 5.9 -13 3
Agonist activity at human GPR120 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assayAgonist activity at human GPR120 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.ejmech.2023.115267
6490 3887 None 48 Human Functional pEC50 = 5.9 5.9 -13 3
Agonist activity at human GPR120 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assayAgonist activity at human GPR120 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.ejmech.2023.115267
CHEMBL2058533 3887 None 48 Human Functional pEC50 = 5.9 5.9 -13 3
Agonist activity at human GPR120 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assayAgonist activity at human GPR120 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.ejmech.2023.115267
137657736 159732 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 385 7 1 4 5.2 Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4103573 159732 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 385 7 1 4 5.2 Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
90405989 156051 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 383 7 1 3 5.3 Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4061340 156051 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 383 7 1 3 5.3 Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
137653883 158614 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 493 7 1 4 6.6 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F 10.1016/j.bmcl.2017.06.028
CHEMBL4091291 158614 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 493 7 1 4 6.6 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F 10.1016/j.bmcl.2017.06.028
11195 3882 None 0 Mouse Functional pEC50 = 6.8 6.8 -1 2
Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
86280676 3882 None 0 Mouse Functional pEC50 = 6.8 6.8 -1 2
Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
CHEMBL3941880 3882 None 0 Mouse Functional pEC50 = 6.8 6.8 -1 2
Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
87055315 165852 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 349 8 2 3 4.7 CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 10.1016/j.bmcl.2018.06.047
CHEMBL4246850 165852 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 349 8 2 3 4.7 CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 10.1016/j.bmcl.2018.06.047
145986046 166007 None 0 Human Functional pEC50 = 5.8 5.8 19 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 437 10 1 6 4.3 CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4250196 166007 None 0 Human Functional pEC50 = 5.8 5.8 19 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 437 10 1 6 4.3 CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
3038495 708 None 33 Human Functional pEC50 = 5.8 5.8 -2754 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.6019/CHEMBL5442687
7625 708 None 33 Human Functional pEC50 = 5.8 5.8 -2754 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.6019/CHEMBL5442687
CHEMBL25236 708 None 33 Human Functional pEC50 = 5.8 5.8 -2754 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.6019/CHEMBL5442687
142738582 184626 None 0 Human Functional pEC50 = 4.8 4.8 -42 2
Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)
ChEMBL 293 4 2 1 4.5 Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1 10.1021/acs.jmedchem.1c00031
CHEMBL4847662 184626 None 0 Human Functional pEC50 = 4.8 4.8 -42 2
Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)
ChEMBL 293 4 2 1 4.5 Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1 10.1021/acs.jmedchem.1c00031
134157207 154300 None 0 Human Functional pEC50 = 6.8 6.8 -3 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 386 7 1 3 5.3 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3985939 154300 None 0 Human Functional pEC50 = 6.8 6.8 -3 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 386 7 1 3 5.3 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
134135468 144563 None 0 Mouse Functional pEC50 = 5.8 5.8 -1 2
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 389 4 1 3 4.8 O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3906716 144563 None 0 Mouse Functional pEC50 = 5.8 5.8 -1 2
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 389 4 1 3 4.8 O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 10.1021/acsmedchemlett.6b00360
134145700 148839 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 400 7 1 4 5.0 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3940429 148839 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 400 7 1 4 5.0 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
134155067 151395 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 401 7 1 5 4.4 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3960738 151395 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 401 7 1 5 4.4 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
137646995 157925 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 391 7 1 4 5.0 O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4083499 157925 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 391 7 1 4 5.0 O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1 10.1016/j.bmcl.2017.06.028
137660451 159338 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 445 7 1 4 5.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4099026 159338 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 445 7 1 4 5.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
134151115 152288 None 0 Human Functional pEC50 = 6.8 6.8 -4 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 336 6 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3968537 152288 None 0 Human Functional pEC50 = 6.8 6.8 -4 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 336 6 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
90418653 137600 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL3754160 137600 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C 10.1021/acsmedchemlett.7b00233
86343594 163692 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 461 7 1 3 5.6 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4203544 163692 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 461 7 1 3 5.6 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1 10.1016/j.bmcl.2018.02.013
137641343 157149 None 0 Human Functional pEC50 = 6.8 6.8 117 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4074009 157149 None 0 Human Functional pEC50 = 6.8 6.8 117 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
134132142 144957 None 0 Mouse Functional pEC50 = 7.8 7.8 13 2
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
CHEMBL3909872 144957 None 0 Mouse Functional pEC50 = 7.8 7.8 13 2
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
134132142 144957 None 0 Mouse Functional pEC50 = 7.8 7.8 13 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3909872 144957 None 0 Mouse Functional pEC50 = 7.8 7.8 13 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
57522038 3887 None 48 Mouse Functional pEC50 = 7.8 7.8 13 3
Agonist activity at mouse GPR120Agonist activity at mouse GPR120
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
6490 3887 None 48 Mouse Functional pEC50 = 7.8 7.8 13 3
Agonist activity at mouse GPR120Agonist activity at mouse GPR120
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
CHEMBL2058533 3887 None 48 Mouse Functional pEC50 = 7.8 7.8 13 3
Agonist activity at mouse GPR120Agonist activity at mouse GPR120
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
137635671 156082 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4061699 156082 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
137632299 156558 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 455 7 1 4 5.8 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4067368 156558 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 455 7 1 4 5.8 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
137661886 159421 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 453 7 1 4 6.2 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4099943 159421 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 453 7 1 4 6.2 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C 10.1016/j.bmcl.2017.06.028
137657968 159686 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4103081 159686 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
90418139 162676 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 443 7 1 4 5.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4168786 162676 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 443 7 1 4 5.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
90406219 164409 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 469 7 1 3 5.8 O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F 10.1016/j.bmcl.2018.02.013
CHEMBL4212281 164409 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 469 7 1 3 5.8 O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F 10.1016/j.bmcl.2018.02.013
90406961 163877 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 445 7 1 3 5.9 OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F 10.1016/j.bmcl.2018.02.013
CHEMBL4205879 163877 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 445 7 1 3 5.9 OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F 10.1016/j.bmcl.2018.02.013
90406842 164801 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 427 7 1 3 5.5 Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C 10.1016/j.bmcl.2018.02.013
CHEMBL4217252 164801 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 427 7 1 3 5.5 Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C 10.1016/j.bmcl.2018.02.013
85472222 163161 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 437 9 1 4 6.7 CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4176414 163161 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 437 9 1 4 6.7 CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
51349861 58846 None 0 Human Functional pEC50 = 4.8 4.8 -77 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 348 8 1 3 5.1 O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1 10.1021/jm300215x
CHEMBL1688454 58846 None 0 Human Functional pEC50 = 4.8 4.8 -77 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 348 8 1 3 5.1 O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1 10.1021/jm300215x
10466 166765 None 59 Human Functional pEC50 = 5.8 5.8 12 2
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 272 15 2 2 4.5 O=C(O)CCCCCCCCCCCCCCCO 10.1039/C7MD00130D
CHEMBL4281719 166765 None 59 Human Functional pEC50 = 5.8 5.8 12 2
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 272 15 2 2 4.5 O=C(O)CCCCCCCCCCCCCCCO 10.1039/C7MD00130D
134153222 152614 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3971461 152614 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 10.1021/acs.jmedchem.6b00685
134134149 143462 None 0 Human Functional pEC50 = 6.8 6.8 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3897776 143462 None 0 Human Functional pEC50 = 6.8 6.8 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 10.1016/j.bmcl.2016.10.054
134155480 151340 None 0 Human Functional pEC50 = 6.8 6.8 38 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3960231 151340 None 0 Human Functional pEC50 = 6.8 6.8 38 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
137648785 157702 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 427 7 1 4 5.2 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4080995 157702 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 427 7 1 4 5.2 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
137655521 159081 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 467 8 1 4 6.1 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4096332 159081 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 467 8 1 4 6.1 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
25109512 189873 None 0 Human Functional pEC50 = 5.8 5.8 12 2
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 382 10 1 5 4.8 O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1 10.1021/jm800970b
CHEMBL515995 189873 None 0 Human Functional pEC50 = 5.8 5.8 12 2
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 382 10 1 5 4.8 O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1 10.1021/jm800970b
137641343 157149 None 0 Human Functional pEC50 = 6.8 6.8 117 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4074009 157149 None 0 Human Functional pEC50 = 6.8 6.8 117 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
90418782 163178 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 513 7 1 4 6.6 O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4176642 163178 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 513 7 1 4 6.6 O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
90407441 163809 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 417 7 1 3 6.0 Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2018.02.013
CHEMBL4205035 163809 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 417 7 1 3 6.0 Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2018.02.013
54580132 61824 None 0 Human Functional pEC50 = 5.8 5.8 -3 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 334 6 1 2 4.0 O=C(O)CCc1ccc(OCc2ccccc2Br)cc1 10.1021/jm300215x
CHEMBL1773253 61824 None 0 Human Functional pEC50 = 5.8 5.8 -3 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 334 6 1 2 4.0 O=C(O)CCc1ccc(OCc2ccccc2Br)cc1 10.1021/jm300215x
7789 100739 None 56 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 300 16 2 2 5.3 CCCCCCC(O)CCCCCCCCCCC(=O)O 10.1039/C7MD00130D
CHEMBL292352 100739 None 56 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 300 16 2 2 5.3 CCCCCCC(O)CCCCCCCCCCC(=O)O 10.1039/C7MD00130D
86343595 164790 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 461 7 1 3 5.6 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4217161 164790 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 461 7 1 3 5.6 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1 10.1016/j.bmcl.2018.02.013
137646145 158116 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 385 7 1 4 5.2 Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4085643 158116 None 0 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 385 7 1 4 5.2 Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
57521809 76291 None 0 Human Functional pEC50 = 6.8 6.8 13 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
CHEMBL2058520 76291 None 0 Human Functional pEC50 = 6.8 6.8 13 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
CHEMBL4210970 76291 None 0 Human Functional pEC50 = 6.8 6.8 13 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
86294762 164210 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 477 7 1 3 6.2 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4209823 164210 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 477 7 1 3 6.2 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1 10.1016/j.bmcl.2018.02.013
134133355 143623 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 413 6 1 5 4.2 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3898962 143623 None 0 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 413 6 1 5 4.2 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
137657488 159774 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 441 7 1 4 5.5 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4104082 159774 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 441 7 1 4 5.5 Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
134146386 148995 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3941726 148995 None 0 Human Functional pEC50 = 6.8 6.8 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
46892131 144759 None 3 Human Functional pEC50 = 6.7 6.7 -3 2
Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3908362 144759 None 3 Human Functional pEC50 = 6.7 6.7 -3 2
Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
134143163 145832 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 362 8 1 3 5.7 Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3916564 145832 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 362 8 1 3 5.7 Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 10.1016/j.bmcl.2016.10.054
90406575 164449 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 455 8 1 4 5.4 COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2018.02.013
CHEMBL4212717 164449 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 455 8 1 4 5.4 COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2018.02.013
134136175 142767 None 0 Human Functional pEC50 = 6.7 6.7 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3892019 142767 None 0 Human Functional pEC50 = 6.7 6.7 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
145983493 165599 None 0 Human Functional pEC50 = 6.7 6.7 371 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 442 10 1 4 5.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4240607 165599 None 0 Human Functional pEC50 = 6.7 6.7 371 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 442 10 1 4 5.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
134146021 149152 None 0 Human Functional pEC50 = 6.7 6.7 -5 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 392 7 1 3 5.3 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3942922 149152 None 0 Human Functional pEC50 = 6.7 6.7 -5 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 392 7 1 3 5.3 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 10.1016/j.bmcl.2016.10.054
134154330 152969 None 0 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 340 7 1 3 4.5 O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3974501 152969 None 0 Mouse Functional pEC50 = 5.7 5.7 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 340 7 1 3 4.5 O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
137638355 156921 None 0 Human Functional pEC50 = 6.7 6.7 97 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 318 6 1 2 4.6 Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4071290 156921 None 0 Human Functional pEC50 = 6.7 6.7 97 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 318 6 1 2 4.6 Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
134147174 149791 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 6 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3947787 149791 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 6 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
137649360 157478 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 495 7 1 4 6.3 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4078286 157478 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 495 7 1 4 6.3 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
90418662 159033 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 395 8 1 4 5.6 CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4095819 159033 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 395 8 1 4 5.6 CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
73777175 143996 None 0 Mouse Functional pEC50 = 6.7 6.7 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3901994 143996 None 0 Mouse Functional pEC50 = 6.7 6.7 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
57521814 76296 None 0 Human Functional pEC50 = 6.7 6.7 10 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 362 8 1 3 5.0 COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
CHEMBL2058525 76296 None 0 Human Functional pEC50 = 6.7 6.7 10 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 362 8 1 3 5.0 COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
90418662 159033 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 395 8 1 4 5.6 CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4095819 159033 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 395 8 1 4 5.6 CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
85470884 164099 None 3 Mouse Functional pEC50 = 6.7 6.7 -2 5
Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4208325 164099 None 3 Mouse Functional pEC50 = 6.7 6.7 -2 5
Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
57521808 76290 None 0 Human Functional pEC50 = 5.7 5.7 -3 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
CHEMBL2058519 76290 None 0 Human Functional pEC50 = 5.7 5.7 -3 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
57521809 76291 None 0 Human Functional pEC50 = 6.7 6.7 13 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 346 7 1 2 5.3 Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1016/j.bmc.2017.10.040
CHEMBL2058520 76291 None 0 Human Functional pEC50 = 6.7 6.7 13 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 346 7 1 2 5.3 Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1016/j.bmc.2017.10.040
CHEMBL4210970 76291 None 0 Human Functional pEC50 = 6.7 6.7 13 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 346 7 1 2 5.3 Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1016/j.bmc.2017.10.040
90442468 164577 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 456 8 1 5 4.8 COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 10.1016/j.bmcl.2018.02.013
CHEMBL4214224 164577 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 456 8 1 5 4.8 COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 10.1016/j.bmcl.2018.02.013
134156096 151536 None 0 Human Functional pEC50 = 6.7 6.7 -5 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 400 8 1 3 6.2 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3961950 151536 None 0 Human Functional pEC50 = 6.7 6.7 -5 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 400 8 1 3 6.2 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
137638355 156921 None 0 Human Functional pEC50 = 6.7 6.7 97 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 318 6 1 2 4.6 Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4071290 156921 None 0 Human Functional pEC50 = 6.7 6.7 97 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 318 6 1 2 4.6 Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
137642604 158609 None 0 Human Functional pEC50 = 6.7 6.7 41 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4091228 158609 None 0 Human Functional pEC50 = 6.7 6.7 41 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
137632403 156395 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 1 4 4.9 COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4065447 156395 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 1 4 4.9 COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
84481843 113098 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 333 5 1 3 4.2 Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311322 113098 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 333 5 1 3 4.2 Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
8190727 113101 None 2 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 347 3 1 4 3.6 Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311326 113101 None 2 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 347 3 1 4 3.6 Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1 10.1016/j.bmcl.2014.05.012
137632403 156395 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 1 4 4.9 COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4065447 156395 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 1 4 4.9 COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
134153562 152812 None 0 Human Functional pEC50 = 7.7 7.7 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 394 7 1 3 4.9 O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F 10.1016/j.bmcl.2016.10.054
CHEMBL3973101 152812 None 0 Human Functional pEC50 = 7.7 7.7 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 394 7 1 3 4.9 O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F 10.1016/j.bmcl.2016.10.054
87055315 165852 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120Agonist activity at human GPR120
ChEMBL 349 8 2 3 4.7 CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 10.1016/j.bmcl.2018.06.047
CHEMBL4246850 165852 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120Agonist activity at human GPR120
ChEMBL 349 8 2 3 4.7 CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 10.1016/j.bmcl.2018.06.047
73777156 152804 None 0 Human Functional pEC50 = 6.7 6.7 -1 3
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3973034 152804 None 0 Human Functional pEC50 = 6.7 6.7 -1 3
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
137642604 158609 None 0 Human Functional pEC50 = 6.7 6.7 41 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4091228 158609 None 0 Human Functional pEC50 = 6.7 6.7 41 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
90418651 162508 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 469 8 1 4 6.6 CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
CHEMBL4166012 162508 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 469 8 1 4 6.6 CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
59455552 156132 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 384 7 1 4 4.7 Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4062462 156132 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 384 7 1 4 4.7 Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
134154417 152793 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3972973 152793 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
57521813 76295 None 0 Human Functional pEC50 = 5.7 5.7 -1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 400 7 1 2 6.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm300215x
CHEMBL2058524 76295 None 0 Human Functional pEC50 = 5.7 5.7 -1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 400 7 1 2 6.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm300215x
134134846 144327 None 0 Human Functional pEC50 = 6.7 6.7 -1 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 337 3 0 3 4.2 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3904654 144327 None 0 Human Functional pEC50 = 6.7 6.7 -1 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 337 3 0 3 4.2 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
54582149 61826 None 0 Human Functional pEC50 = 4.7 4.7 -33 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 281 6 1 3 3.2 N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
CHEMBL1773255 61826 None 0 Human Functional pEC50 = 4.7 4.7 -33 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 281 6 1 3 3.2 N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
134146958 149697 None 0 Human Functional pEC50 = 7.7 7.7 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 388 6 1 3 5.1 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3947070 149697 None 0 Human Functional pEC50 = 7.7 7.7 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 388 6 1 3 5.1 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
73777085 153319 None 0 Human Functional pEC50 = 5.7 5.7 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3977361 153319 None 0 Human Functional pEC50 = 5.7 5.7 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
91826086 115000 None 44 Human Functional pEC50 = 5.7 5.7 -2398 4
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 418 7 3 7 3.2 CNc1nc(NCc2ccc(NS(C)(=O)=O)cc2Cl)cc(-c2ccccn2)n1 10.6019/CHEMBL5442687
CHEMBL3342358 115000 None 44 Human Functional pEC50 = 5.7 5.7 -2398 4
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 418 7 3 7 3.2 CNc1nc(NCc2ccc(NS(C)(=O)=O)cc2Cl)cc(-c2ccccn2)n1 10.6019/CHEMBL5442687
90418650 157447 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL4077787 157447 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
90418650 157447 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4077787 157447 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
57521913 76297 None 0 Human Functional pEC50 = 5.7 5.7 2 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 376 9 1 3 5.3 CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
CHEMBL2058526 76297 None 0 Human Functional pEC50 = 5.7 5.7 2 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 376 9 1 3 5.3 CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
134145750 149233 None 0 Mouse Functional pEC50 = 5.7 5.7 3 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 324 6 1 2 4.6 O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3943430 149233 None 0 Mouse Functional pEC50 = 5.7 5.7 3 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 324 6 1 2 4.6 O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
134141029 147255 None 0 Mouse Functional pEC50 = 7.7 7.7 4 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 352 6 1 3 4.8 O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3927879 147255 None 0 Mouse Functional pEC50 = 7.7 7.7 4 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 352 6 1 3 4.8 O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
145984594 166028 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 436 9 1 6 4.2 CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4250664 166028 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 436 9 1 6 4.2 CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1 10.1016/j.bmcl.2018.06.047
134156455 154410 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 394 6 1 5 4.3 Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
CHEMBL3986721 154410 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 394 6 1 5 4.3 Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
73777153 142910 None 0 Human Functional pEC50 = 6.7 6.7 -2 3
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3893026 142910 None 0 Human Functional pEC50 = 6.7 6.7 -2 3
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
137645347 157894 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 394 7 1 2 6.2 Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4083233 157894 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 394 7 1 2 6.2 Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
134147107 149964 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 417 3 1 3 5.5 O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3949142 149964 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 417 3 1 3 5.5 O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 10.1021/acsmedchemlett.6b00360
25150014 3885 None 44 Human Functional pEC50 = 5.7 5.7 -44 9
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 264 3 1 1 3.4 OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C 10.1021/jm300215x
3952 3885 None 44 Human Functional pEC50 = 5.7 5.7 -44 9
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 264 3 1 1 3.4 OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C 10.1021/jm300215x
CHEMBL449588 3885 None 44 Human Functional pEC50 = 5.7 5.7 -44 9
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 264 3 1 1 3.4 OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C 10.1021/jm300215x
137646188 157697 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 406 7 1 3 6.0 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 10.1016/j.bmcl.2017.01.034
CHEMBL4080936 157697 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 406 7 1 3 6.0 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 10.1016/j.bmcl.2017.01.034
137660451 159338 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 445 7 1 4 5.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4099026 159338 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 445 7 1 4 5.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
57521915 76299 None 0 Human Functional pEC50 = 6.6 6.6 15 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 378 8 1 3 5.7 CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
CHEMBL2058528 76299 None 0 Human Functional pEC50 = 6.6 6.6 15 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 378 8 1 3 5.7 CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
11195 3882 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
86280676 3882 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
CHEMBL3941880 3882 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
134152545 153566 None 0 Human Functional pEC50 = 5.6 5.6 -3 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 380 3 0 4 4.2 N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3979588 153566 None 0 Human Functional pEC50 = 5.6 5.6 -3 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 380 3 0 4 4.2 N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
137636733 156295 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 348 6 1 2 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br 10.1016/j.bmcl.2017.01.034
CHEMBL4064298 156295 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 348 6 1 2 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br 10.1016/j.bmcl.2017.01.034
90442039 163004 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 509 7 1 4 7.1 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
CHEMBL4173940 163004 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 509 7 1 4 7.1 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
57521916 76300 None 0 Human Functional pEC50 = 6.6 6.6 2 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 366 7 1 2 5.6 O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1 10.1021/jm300215x
CHEMBL2058529 76300 None 0 Human Functional pEC50 = 6.6 6.6 2 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 366 7 1 2 5.6 O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1 10.1021/jm300215x
25098573 2747 None 10 Human Functional pEC50 = 5.6 5.6 8 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 10.1021/jm300215x
5587 2747 None 10 Human Functional pEC50 = 5.6 5.6 8 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 10.1021/jm300215x
CHEMBL463785 2747 None 10 Human Functional pEC50 = 5.6 5.6 8 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 10.1021/jm300215x
23136411 58849 None 0 Human Functional pEC50 = 5.6 5.6 -11 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1 10.1021/jm300215x
CHEMBL1688457 58849 None 0 Human Functional pEC50 = 5.6 5.6 -11 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1 10.1021/jm300215x
134143370 145891 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 442 7 1 6 4.0 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3916986 145891 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 442 7 1 6 4.0 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 10.1021/acsmedchemlett.6b00394
145983824 165834 None 0 Human Functional pEC50 = 4.6 4.6 -6 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 484 13 1 4 6.3 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4246334 165834 None 0 Human Functional pEC50 = 4.6 4.6 -6 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 484 13 1 4 6.3 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
134129938 142527 None 0 Human Functional pEC50 = 7.6 7.6 263 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 414 6 1 4 5.0 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3890089 142527 None 0 Human Functional pEC50 = 7.6 7.6 263 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 414 6 1 4 5.0 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
134153298 152455 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 412 6 1 4 4.8 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3970166 152455 None 0 Human Functional pEC50 = 7.6 7.6 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 412 6 1 4 4.8 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
85472225 162856 None 0 Human Functional pEC50 = 7.6 7.6 2 3
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4171724 162856 None 0 Human Functional pEC50 = 7.6 7.6 2 3
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
134153546 152670 None 0 Human Functional pEC50 = 6.6 6.6 8 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3971857 152670 None 0 Human Functional pEC50 = 6.6 6.6 8 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
137636733 156295 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 348 6 1 2 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br 10.1016/j.bmcl.2017.01.034
CHEMBL4064298 156295 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 348 6 1 2 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br 10.1016/j.bmcl.2017.01.034
82051652 158690 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 284 6 1 2 3.9 Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4092090 158690 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 284 6 1 2 3.9 Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
137654721 158831 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 328 8 1 3 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C 10.1016/j.bmcl.2017.01.034
CHEMBL4093589 158831 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 328 8 1 3 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C 10.1016/j.bmcl.2017.01.034
711134 113088 None 13 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 291 4 1 3 3.1 COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311305 113088 None 13 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 291 4 1 3 3.1 COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
137646188 157697 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 406 7 1 3 6.0 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 10.1016/j.bmcl.2017.01.034
CHEMBL4080936 157697 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 406 7 1 3 6.0 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 10.1016/j.bmcl.2017.01.034
134155277 151414 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl 10.1016/j.bmcl.2016.10.054
CHEMBL3961009 151414 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl 10.1016/j.bmcl.2016.10.054
10531 1420 None 13 Human Functional pEC50 = 5.6 5.6 -3019 29
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442687
10531.0 1420 None 13 Human Functional pEC50 = 5.6 5.6 -3019 29
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442687
121 1420 None 13 Human Functional pEC50 = 5.6 5.6 -3019 29
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442687
888 1420 None 13 Human Functional pEC50 = 5.6 5.6 -3019 29
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442687
CHEMBL1732 1420 None 13 Human Functional pEC50 = 5.6 5.6 -3019 29
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442687
DB00320 1420 None 13 Human Functional pEC50 = 5.6 5.6 -3019 29
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.6019/CHEMBL5442687
1049 363 None 48 Human Functional pEC50 = 5.6 5.6 -1 3
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm800970b
4618 363 None 48 Human Functional pEC50 = 5.6 5.6 -1 3
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm800970b
5280934 363 None 48 Human Functional pEC50 = 5.6 5.6 -1 3
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm800970b
CHEMBL8739 363 None 48 Human Functional pEC50 = 5.6 5.6 -1 3
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm800970b
DB00132 363 None 48 Human Functional pEC50 = 5.6 5.6 -1 3
Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm800970b
90406335 163925 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 457 7 1 3 5.8 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F 10.1016/j.bmcl.2018.02.013
CHEMBL4206369 163925 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 457 7 1 3 5.8 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F 10.1016/j.bmcl.2018.02.013
134138318 148107 None 0 Mouse Functional pEC50 = 6.6 6.6 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 378 9 1 4 5.4 COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3934450 148107 None 0 Mouse Functional pEC50 = 6.6 6.6 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 378 9 1 4 5.4 COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 10.1016/j.bmcl.2016.10.054
134144214 150446 None 0 Mouse Functional pEC50 = 7.6 7.6 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 8 1 3 5.7 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3953203 150446 None 0 Mouse Functional pEC50 = 7.6 7.6 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 8 1 3 5.7 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
59455555 158808 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 399 7 1 4 5.5 Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4093383 158808 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 399 7 1 4 5.5 Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
73776979 143446 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 5 1 3 5.9 O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3897637 143446 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 5 1 3 5.9 O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
137654721 158831 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 328 8 1 3 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C 10.1016/j.bmcl.2017.01.034
CHEMBL4093589 158831 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 328 8 1 3 4.4 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C 10.1016/j.bmcl.2017.01.034
82051652 158690 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 284 6 1 2 3.9 Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4092090 158690 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 284 6 1 2 3.9 Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
137657736 159732 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 385 7 1 4 5.2 Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4103573 159732 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 385 7 1 4 5.2 Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
145986262 165940 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 428 8 1 4 4.7 O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F 10.1016/j.bmcl.2018.06.047
CHEMBL4248845 165940 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 428 8 1 4 4.7 O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F 10.1016/j.bmcl.2018.06.047
134154473 152463 None 0 Human Functional pEC50 = 7.6 7.6 218 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 370 6 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3970238 152463 None 0 Human Functional pEC50 = 7.6 7.6 218 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 370 6 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134139171 146351 None 0 Mouse Functional pEC50 = 7.6 7.6 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 6 1 3 5.4 Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3920591 146351 None 0 Mouse Functional pEC50 = 7.6 7.6 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 6 1 3 5.4 Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 10.1016/j.bmcl.2016.10.054
86343964 163715 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 421 7 1 3 5.5 Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1 10.1016/j.bmcl.2018.02.013
CHEMBL4203774 163715 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 421 7 1 3 5.5 Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1 10.1016/j.bmcl.2018.02.013
137647294 158044 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 461 8 1 4 6.9 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4084679 158044 None 0 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 461 8 1 4 6.9 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C 10.1016/j.bmcl.2017.06.028
24801690 98094 None 20 Human Functional pEC50 = 5.6 5.6 -295 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 593 9 5 5 4.5 CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 10.6019/CHEMBL5442687
CHEMBL273083 98094 None 20 Human Functional pEC50 = 5.6 5.6 -295 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 593 9 5 5 4.5 CSc1ccc(C(=O)N[C@@H]2CCCC[C@@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1 10.6019/CHEMBL5442687
90407659 164328 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 440 7 1 4 5.1 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 10.1016/j.bmcl.2018.02.013
CHEMBL4211144 164328 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 440 7 1 4 5.1 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 10.1016/j.bmcl.2018.02.013
134157586 154252 None 0 Mouse Functional pEC50 = 7.5 7.5 3 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 366 8 1 3 5.5 O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3985509 154252 None 0 Mouse Functional pEC50 = 7.5 7.5 3 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 366 8 1 3 5.5 O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
137636575 155991 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 479 7 1 4 6.0 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4060663 155991 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 479 7 1 4 6.0 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
134133675 143349 None 0 Human Functional pEC50 = 6.5 6.5 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 318 8 1 3 4.1 CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3896714 143349 None 0 Human Functional pEC50 = 6.5 6.5 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 318 8 1 3 4.1 CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
90404813 164603 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 473 7 1 3 6.3 CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O 10.1016/j.bmcl.2018.02.013
CHEMBL4214698 164603 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 473 7 1 3 6.3 CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O 10.1016/j.bmcl.2018.02.013
11374217 3597 None 38 Human Functional pEC50 = 5.5 5.5 -363 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
5813 3597 None 38 Human Functional pEC50 = 5.5 5.5 -363 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
CHEMBL469695 3597 None 38 Human Functional pEC50 = 5.5 5.5 -363 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
57521812 76294 None 0 Human Functional pEC50 = 6.5 6.5 2 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 410 7 1 2 5.7 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1 10.1021/jm300215x
CHEMBL2058523 76294 None 0 Human Functional pEC50 = 6.5 6.5 2 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 410 7 1 2 5.7 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1 10.1021/jm300215x
137633536 156386 None 0 Human Functional pEC50 = 6.5 6.5 -4 6
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
CHEMBL4065397 156386 None 0 Human Functional pEC50 = 6.5 6.5 -4 6
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
134154330 152969 None 0 Human Functional pEC50 = 5.5 5.5 -1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 340 7 1 3 4.5 O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3974501 152969 None 0 Human Functional pEC50 = 5.5 5.5 -1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 340 7 1 3 4.5 O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
134148110 149658 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3946820 149658 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134138802 148007 None 0 Human Functional pEC50 = 6.5 6.5 -4 2
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3933619 148007 None 0 Human Functional pEC50 = 6.5 6.5 -4 2
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
3376937 124204 None 45 Human Functional pEC50 = 5.5 5.5 -70 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 365 4 3 4 3.3 COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 10.6019/CHEMBL5442687
CHEMBL3633893 124204 None 45 Human Functional pEC50 = 5.5 5.5 -70 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 365 4 3 4 3.3 COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 10.6019/CHEMBL5442687
46892131 144759 None 3 Human Functional pEC50 = 6.5 6.5 -3 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3908362 144759 None 3 Human Functional pEC50 = 6.5 6.5 -3 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
137661388 159333 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C 10.1016/j.bmcl.2017.01.034
CHEMBL4098969 159333 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C 10.1016/j.bmcl.2017.01.034
134133297 143866 None 0 Human Functional pEC50 = 6.5 6.5 -3 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 372 7 1 3 4.9 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3900990 143866 None 0 Human Functional pEC50 = 6.5 6.5 -3 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 372 7 1 3 4.9 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
57521811 76293 None 0 Human Functional pEC50 = 6.5 6.5 1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 366 7 1 2 5.6 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1 10.1021/jm300215x
CHEMBL2058522 76293 None 0 Human Functional pEC50 = 6.5 6.5 1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 366 7 1 2 5.6 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1 10.1021/jm300215x
24825492 149630 None 0 Human Functional pEC50 = 5.5 5.5 -9 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 333 6 2 2 4.1 O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1 10.1021/jm300215x
CHEMBL394666 149630 None 0 Human Functional pEC50 = 5.5 5.5 -9 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 333 6 2 2 4.1 O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1 10.1021/jm300215x
85472227 162282 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 519 7 1 4 6.8 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4162566 162282 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 519 7 1 4 6.8 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 10.1021/acsmedchemlett.7b00233
134149615 148664 None 0 Mouse Functional pEC50 = 7.5 7.5 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
CHEMBL3939004 148664 None 0 Mouse Functional pEC50 = 7.5 7.5 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
73777174 150542 None 0 Human Functional pEC50 = 5.5 5.5 -2 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3954140 150542 None 0 Human Functional pEC50 = 5.5 5.5 -2 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
145960576 162246 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 527 8 1 5 6.6 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4161929 162246 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 527 8 1 5 6.6 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
134145195 150511 None 0 Mouse Functional pEC50 = 6.5 6.5 - 1
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 392 5 1 5 4.4 Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1 10.1016/j.bmcl.2016.10.054
CHEMBL3953859 150511 None 0 Mouse Functional pEC50 = 6.5 6.5 - 1
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 392 5 1 5 4.4 Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1 10.1016/j.bmcl.2016.10.054
1052 2321 None 51 Human Functional pEC50 = 6.5 6.5 3 4
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 10.1016/j.bmcl.2014.05.012
3323 2321 None 51 Human Functional pEC50 = 6.5 6.5 3 4
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 10.1016/j.bmcl.2014.05.012
5280450 2321 None 51 Human Functional pEC50 = 6.5 6.5 3 4
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 10.1016/j.bmcl.2014.05.012
CHEMBL267476 2321 None 51 Human Functional pEC50 = 6.5 6.5 3 4
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 10.1016/j.bmcl.2014.05.012
DB14104 2321 None 51 Human Functional pEC50 = 6.5 6.5 3 4
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 10.1016/j.bmcl.2014.05.012
900631 113100 None 14 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 333 3 1 4 3.2 Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311325 113100 None 14 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 333 3 1 4 3.2 Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1 10.1016/j.bmcl.2014.05.012
118707173 113102 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 331 6 1 3 3.8 C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311327 113102 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 331 6 1 3 3.8 C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
137633536 156386 None 0 Human Functional pEC50 = 6.5 6.5 -4 6
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
CHEMBL4065397 156386 None 0 Human Functional pEC50 = 6.5 6.5 -4 6
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
137661388 159333 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C 10.1016/j.bmcl.2017.01.034
CHEMBL4098969 159333 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C 10.1016/j.bmcl.2017.01.034
1050 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1016/j.bmcl.2020.127650
11595431 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1016/j.bmcl.2020.127650
CHEMBL207881 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1016/j.bmcl.2020.127650
825631 113089 None 11 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 291 4 1 3 3.1 COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311306 113089 None 11 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 291 4 1 3 3.1 COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1 10.1016/j.bmcl.2014.05.012
841618 113096 None 12 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 309 3 1 2 4.1 Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311318 113096 None 12 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 309 3 1 2 4.1 Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
134141270 146898 None 0 Mouse Functional pEC50 = 7.5 7.5 3 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 334 8 1 3 4.6 CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3924759 146898 None 0 Mouse Functional pEC50 = 7.5 7.5 3 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 334 8 1 3 4.6 CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 10.1016/j.bmcl.2016.10.054
134145412 149359 None 0 Mouse Functional pEC50 = 7.5 7.5 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 330 8 1 3 4.3 O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3944507 149359 None 0 Mouse Functional pEC50 = 7.5 7.5 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 330 8 1 3 4.3 O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
134147601 150116 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3950444 150116 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
10204153 3533 None 31 Human Functional pEC50 = 5.5 5.5 -23 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 5 0 6 5.2 Cc1sc(c(n1)C(=O)N1CCC[C@H]1Cc1nnc(o1)c1ccccc1)c1ccccc1F 10.6019/CHEMBL5442687
9136 3533 None 31 Human Functional pEC50 = 5.5 5.5 -23 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 5 0 6 5.2 Cc1sc(c(n1)C(=O)N1CCC[C@H]1Cc1nnc(o1)c1ccccc1)c1ccccc1F 10.6019/CHEMBL5442687
CHEMBL2110363 3533 None 31 Human Functional pEC50 = 5.5 5.5 -23 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 5 0 6 5.2 Cc1sc(c(n1)C(=O)N1CCC[C@H]1Cc1nnc(o1)c1ccccc1)c1ccccc1F 10.6019/CHEMBL5442687
1049 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm300215x
4618 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm300215x
5280934 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm300215x
CHEMBL8739 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm300215x
DB00132 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 10.1021/jm300215x
134143899 150327 None 0 Mouse Functional pEC50 = 6.5 6.5 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 5 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3952316 150327 None 0 Mouse Functional pEC50 = 6.5 6.5 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 5 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
73777063 1154 None 36 Mouse Functional pEC50 = 7.5 7.5 4 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
8418 1154 None 36 Mouse Functional pEC50 = 7.5 7.5 4 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
CHEMBL3919973 1154 None 36 Mouse Functional pEC50 = 7.5 7.5 4 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
134152336 153545 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 408 5 1 5 4.2 Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
CHEMBL3979448 153545 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 408 5 1 5 4.2 Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
117886639 148538 None 0 Human Functional pEC50 = 5.5 5.5 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
CHEMBL3937916 148538 None 0 Human Functional pEC50 = 5.5 5.5 -1 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
90417528 162266 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 513 9 1 4 7.2 CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4162353 162266 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 513 9 1 4 7.2 CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
2131 3499 None 46 Human Functional pEC50 = 5.5 5.5 -323 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.6019/CHEMBL5442687
6604009 3499 None 46 Human Functional pEC50 = 5.5 5.5 -323 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.6019/CHEMBL5442687
CHEMBL10284 3499 None 46 Human Functional pEC50 = 5.5 5.5 -323 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.6019/CHEMBL5442687
85472359 162223 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 471 8 1 4 6.3 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4161536 162223 None 0 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 471 8 1 4 6.3 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
134148736 148642 None 0 Mouse Functional pEC50 = 7.5 7.5 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 383 8 1 4 5.4 O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3938783 148642 None 0 Mouse Functional pEC50 = 7.5 7.5 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 383 8 1 4 5.4 O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
134156096 151536 None 0 Mouse Functional pEC50 = 7.5 7.5 5 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 400 8 1 3 6.2 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3961950 151536 None 0 Mouse Functional pEC50 = 7.5 7.5 5 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 400 8 1 3 6.2 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
137649360 157478 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.3 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4078286 157478 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.3 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
86343961 164382 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 435 7 1 3 5.8 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C 10.1016/j.bmcl.2018.02.013
CHEMBL4211967 164382 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 435 7 1 3 5.8 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C 10.1016/j.bmcl.2018.02.013
145985748 165738 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 444 9 1 4 5.4 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4243863 165738 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 444 9 1 4 5.4 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
134156727 153723 None 0 Human Functional pEC50 = 7.5 7.5 -4 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3980898 153723 None 0 Human Functional pEC50 = 7.5 7.5 -4 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
134151115 152288 None 0 Mouse Functional pEC50 = 7.5 7.5 4 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 336 6 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3968537 152288 None 0 Mouse Functional pEC50 = 7.5 7.5 4 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 336 6 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
137631865 156425 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 399 7 1 4 5.5 Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4065769 156425 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 399 7 1 4 5.5 Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
1050 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1016/j.bmcl.2018.06.047
11595431 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1016/j.bmcl.2018.06.047
CHEMBL207881 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1016/j.bmcl.2018.06.047
73777065 147344 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 4 1 3 5.7 CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3928591 147344 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 4 1 3 5.7 CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
134146021 149152 None 0 Mouse Functional pEC50 = 7.4 7.4 5 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 392 7 1 3 5.3 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3942922 149152 None 0 Mouse Functional pEC50 = 7.4 7.4 5 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 392 7 1 3 5.3 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 10.1016/j.bmcl.2016.10.054
73777135 150458 None 0 Human Functional pEC50 = 6.4 6.4 -5 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3953289 150458 None 0 Human Functional pEC50 = 6.4 6.4 -5 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
11250647 1545 None 35 Human Functional pEC50 = 5.4 5.4 -999 7
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 631 12 2 7 5.5 COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F 10.6019/CHEMBL5442687
11250647.0 1545 None 35 Human Functional pEC50 = 5.4 5.4 -999 7
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 631 12 2 7 5.5 COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F 10.6019/CHEMBL5442687
5293 1545 None 35 Human Functional pEC50 = 5.4 5.4 -999 7
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 631 12 2 7 5.5 COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F 10.6019/CHEMBL5442687
8362 1545 None 35 Human Functional pEC50 = 5.4 5.4 -999 7
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 631 12 2 7 5.5 COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F 10.6019/CHEMBL5442687
CHEMBL1208155 1545 None 35 Human Functional pEC50 = 5.4 5.4 -999 7
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 631 12 2 7 5.5 COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F 10.6019/CHEMBL5442687
DB11979 1545 None 35 Human Functional pEC50 = 5.4 5.4 -999 7
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 631 12 2 7 5.5 COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F 10.6019/CHEMBL5442687
137643339 158135 None 0 Human Functional pEC50 = 6.4 6.4 26 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4085843 158135 None 0 Human Functional pEC50 = 6.4 6.4 26 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 10.1016/j.bmcl.2017.01.034
90406970 164871 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 477 7 1 3 6.2 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4218078 164871 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 477 7 1 3 6.2 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1 10.1016/j.bmcl.2018.02.013
134146720 149219 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 443 7 1 6 5.6 COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3943315 149219 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 443 7 1 6 5.6 COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
23136477 58847 None 2 Human Functional pEC50 = 6.4 6.4 15 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 10.1021/jm300215x
CHEMBL1688455 58847 None 2 Human Functional pEC50 = 6.4 6.4 15 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 10.1021/jm300215x
CHEMBL4213909 58847 None 2 Human Functional pEC50 = 6.4 6.4 15 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 10.1021/jm300215x
134132711 145026 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3910333 145026 None 0 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
134145778 149435 None 0 Human Functional pEC50 = 6.4 6.4 13 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 355 3 0 3 4.3 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3945213 149435 None 0 Human Functional pEC50 = 6.4 6.4 13 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 355 3 0 3 4.3 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
137657972 159698 None 0 Human Functional pEC50 = 7.4 7.4 40 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 376 8 1 3 5.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4103243 159698 None 0 Human Functional pEC50 = 7.4 7.4 40 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 376 8 1 3 5.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
5310990 166926 None 8 Human Functional pEC50 = 5.4 5.4 -22 4
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.6019/CHEMBL5442687
CHEMBL428504 166926 None 8 Human Functional pEC50 = 5.4 5.4 -22 4
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.6019/CHEMBL5442687
23136477 58847 None 2 Human Functional pEC50 = 6.4 6.4 15 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 10.1016/j.bmc.2017.10.040
CHEMBL1688455 58847 None 2 Human Functional pEC50 = 6.4 6.4 15 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 10.1016/j.bmc.2017.10.040
CHEMBL4213909 58847 None 2 Human Functional pEC50 = 6.4 6.4 15 2
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 332 7 1 2 5.0 O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 10.1016/j.bmc.2017.10.040
118707084 113073 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 321 5 1 4 3.1 COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311198 113073 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 321 5 1 4 3.1 COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1 10.1016/j.bmcl.2014.05.012
8190712 113097 None 7 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 317 5 1 2 4.4 CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311319 113097 None 7 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 317 5 1 2 4.4 CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
137643339 158135 None 0 Human Functional pEC50 = 6.4 6.4 26 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4085843 158135 None 0 Human Functional pEC50 = 6.4 6.4 26 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 10.1016/j.bmcl.2017.01.034
956298 113087 None 11 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 319 4 1 4 2.9 COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C 10.1016/j.bmcl.2014.05.012
CHEMBL3311303 113087 None 11 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 319 4 1 4 2.9 COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C 10.1016/j.bmcl.2014.05.012
137657972 159698 None 0 Human Functional pEC50 = 7.4 7.4 40 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 376 8 1 3 5.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4103243 159698 None 0 Human Functional pEC50 = 7.4 7.4 40 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 376 8 1 3 5.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
134131874 144945 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 404 6 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3909773 144945 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 404 6 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
86281122 164421 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 453 8 1 3 5.9 CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1 10.1016/j.bmcl.2018.02.013
CHEMBL4212409 164421 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 453 8 1 3 5.9 CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1 10.1016/j.bmcl.2018.02.013
137660302 159532 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 413 8 1 4 5.8 CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4101135 159532 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 413 8 1 4 5.8 CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
137638176 156825 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 457 7 1 4 6.1 Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O 10.1016/j.bmcl.2017.06.028
CHEMBL4070355 156825 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 457 7 1 4 6.1 Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O 10.1016/j.bmcl.2017.06.028
117873187 152433 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 4 1 3 5.7 CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3969920 152433 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 4 1 3 5.7 CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
10416 1879 None 31 Human Functional pEC50 = 5.4 5.4 -199 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 548 9 3 8 4.0 COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl 10.6019/CHEMBL5442687
46861584 1879 None 31 Human Functional pEC50 = 5.4 5.4 -199 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 548 9 3 8 4.0 COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl 10.6019/CHEMBL5442687
CHEMBL2018969 1879 None 31 Human Functional pEC50 = 5.4 5.4 -199 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 548 9 3 8 4.0 COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl 10.6019/CHEMBL5442687
87054900 148849 None 0 Mouse Functional pEC50 = 6.4 6.4 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3940493 148849 None 0 Mouse Functional pEC50 = 6.4 6.4 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 10.1016/j.bmcl.2016.10.054
90418278 162473 None 16 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4165366 162473 None 16 Human Functional pEC50 = 7.4 7.4 1 2
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
73777175 143996 None 0 Human Functional pEC50 = 6.4 6.4 -1 3
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3901994 143996 None 0 Human Functional pEC50 = 6.4 6.4 -1 3
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
60195039 81824 None 0 Human Functional pEC50 = 5.4 5.4 -181 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 377 8 2 2 5.7 CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
CHEMBL2164240 81824 None 0 Human Functional pEC50 = 5.4 5.4 -181 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 377 8 2 2 5.7 CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
134134229 143342 None 0 Mouse Functional pEC50 = 7.4 7.4 1 3
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
CHEMBL3896657 143342 None 0 Mouse Functional pEC50 = 7.4 7.4 1 3
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
134134229 143342 None 0 Mouse Functional pEC50 = 7.4 7.4 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3896657 143342 None 0 Mouse Functional pEC50 = 7.4 7.4 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
86281125 164166 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 445 7 1 3 5.9 OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4209308 164166 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 445 7 1 3 5.9 OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
57522038 3887 None 48 Human Functional pEC50 = 7.4 7.4 -13 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
6490 3887 None 48 Human Functional pEC50 = 7.4 7.4 -13 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
CHEMBL2058533 3887 None 48 Human Functional pEC50 = 7.4 7.4 -13 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
117886649 152167 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 391 4 1 3 5.4 OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3967504 152167 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 391 4 1 3 5.4 OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
134142866 145730 None 0 Mouse Functional pEC50 = 6.4 6.4 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 358 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3915765 145730 None 0 Mouse Functional pEC50 = 6.4 6.4 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 358 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
2705 3842 None 44 Human Functional pEC50 = 5.4 5.4 -676 12
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.6019/CHEMBL5442687
360 3842 None 44 Human Functional pEC50 = 5.4 5.4 -676 12
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.6019/CHEMBL5442687
443879 3842 None 44 Human Functional pEC50 = 5.4 5.4 -676 12
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.6019/CHEMBL5442687
443879.0 3842 None 44 Human Functional pEC50 = 5.4 5.4 -676 12
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.6019/CHEMBL5442687
CHEMBL1382 3842 None 44 Human Functional pEC50 = 5.4 5.4 -676 12
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.6019/CHEMBL5442687
DB01036 3842 None 44 Human Functional pEC50 = 5.4 5.4 -676 12
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 325 7 1 2 5.3 Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O 10.6019/CHEMBL5442687
57521914 76298 None 0 Human Functional pEC50 = 5.4 5.4 -6 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 416 8 1 3 5.8 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1 10.1021/jm300215x
CHEMBL2058527 76298 None 0 Human Functional pEC50 = 5.4 5.4 -6 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 416 8 1 3 5.8 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1 10.1021/jm300215x
60195125 3888 None 8 Human Functional pEC50 = 4.4 4.4 -1096 3
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 499 12 2 5 5.2 OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C 10.1021/jm3002026
9149 3888 None 8 Human Functional pEC50 = 4.4 4.4 -1096 3
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 499 12 2 5 5.2 OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C 10.1021/jm3002026
CHEMBL2164242 3888 None 8 Human Functional pEC50 = 4.4 4.4 -1096 3
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 499 12 2 5 5.2 OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C 10.1021/jm3002026
443375 210065 None 33 Human Functional pEC50 = 5.4 5.4 -22387 9
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.6019/CHEMBL5442687
CHEMBL9506 210065 None 33 Human Functional pEC50 = 5.4 5.4 -22387 9
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.6019/CHEMBL5442687
73777135 150458 None 0 Mouse Functional pEC50 = 7.4 7.4 5 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3953289 150458 None 0 Mouse Functional pEC50 = 7.4 7.4 5 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
73776995 148830 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 4 1 3 5.7 CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3940359 148830 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 4 1 3 5.7 CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
24825509 87980 None 0 Human Functional pEC50 = 5.4 5.4 -29 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 347 8 2 3 5.1 O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1 10.1021/jm300215x
CHEMBL234057 87980 None 0 Human Functional pEC50 = 5.4 5.4 -29 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 347 8 2 3 5.1 O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1 10.1021/jm300215x
134154953 151365 None 0 Human Functional pEC50 = 5.4 5.4 7 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 369 3 0 3 4.6 Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3960369 151365 None 0 Human Functional pEC50 = 5.4 5.4 7 2
Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay
ChEMBL 369 3 0 3 4.6 Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
86343963 164839 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 443 7 1 3 5.5 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4217669 164839 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 443 7 1 3 5.5 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1 10.1016/j.bmcl.2018.02.013
134155950 151179 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 430 6 1 4 4.6 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3959068 151179 None 0 Human Functional pEC50 = 7.4 7.4 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 430 6 1 4 4.6 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 10.1021/acsmedchemlett.6b00394
145984009 165684 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 418 7 1 4 4.7 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4242595 165684 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 418 7 1 4 4.7 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1 10.1016/j.bmcl.2018.06.047
57522038 3887 None 48 Human Functional pEC50 = 5.3 5.3 -13 3
GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.6019/CHEMBL5442687
6490 3887 None 48 Human Functional pEC50 = 5.3 5.3 -13 3
GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.6019/CHEMBL5442687
CHEMBL2058533 3887 None 48 Human Functional pEC50 = 5.3 5.3 -13 3
GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.6019/CHEMBL5442687
134157207 154300 None 0 Mouse Functional pEC50 = 7.3 7.3 3 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 386 7 1 3 5.3 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3985939 154300 None 0 Mouse Functional pEC50 = 7.3 7.3 3 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 386 7 1 3 5.3 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
57522038 3887 None 48 Human Functional pEC50 = 6.3 6.3 -13 3
Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/acsmedchemlett.6b00025
6490 3887 None 48 Human Functional pEC50 = 6.3 6.3 -13 3
Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/acsmedchemlett.6b00025
CHEMBL2058533 3887 None 48 Human Functional pEC50 = 6.3 6.3 -13 3
Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/acsmedchemlett.6b00025
134157563 154096 None 0 Human Functional pEC50 = 6.3 6.3 1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 365 6 1 4 5.0 O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl 10.1016/j.bmcl.2016.10.054
CHEMBL3984072 154096 None 0 Human Functional pEC50 = 6.3 6.3 1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 365 6 1 4 5.0 O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl 10.1016/j.bmcl.2016.10.054
2200 3311 None 35 Human Functional pEC50 = 5.3 5.3 -371 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.6019/CHEMBL5442687
3482 3311 None 35 Human Functional pEC50 = 5.3 5.3 -371 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.6019/CHEMBL5442687
60943 3311 None 35 Human Functional pEC50 = 5.3 5.3 -371 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.6019/CHEMBL5442687
CHEMBL419667 3311 None 35 Human Functional pEC50 = 5.3 5.3 -371 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.6019/CHEMBL5442687
DB13929 3311 None 35 Human Functional pEC50 = 5.3 5.3 -371 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 619 7 2 7 3.3 COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl 10.6019/CHEMBL5442687
54584098 61825 None 2 Human Functional pEC50 = 6.3 6.3 -5 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 334 6 1 2 4.0 O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1 10.1021/jm300215x
CHEMBL1773254 61825 None 2 Human Functional pEC50 = 6.3 6.3 -5 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 334 6 1 2 4.0 O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1 10.1021/jm300215x
54583098 61829 None 0 Human Functional pEC50 = 5.3 5.3 -70 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 331 7 2 2 5.0 O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1 10.1021/jm300215x
CHEMBL1773258 61829 None 0 Human Functional pEC50 = 5.3 5.3 -70 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 331 7 2 2 5.0 O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1 10.1021/jm300215x
3036864 205211 None 16 Human Functional pEC50 = 5.3 5.3 -12302 13
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.6019/CHEMBL5442687
CHEMBL1256645 205211 None 16 Human Functional pEC50 = 5.3 5.3 -12302 13
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.6019/CHEMBL5442687
CHEMBL1814790 205211 None 16 Human Functional pEC50 = 5.3 5.3 -12302 13
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.6019/CHEMBL5442687
CHEMBL62 205211 None 16 Human Functional pEC50 = 5.3 5.3 -12302 13
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.6019/CHEMBL5442687
134157563 154096 None 0 Mouse Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 365 6 1 4 5.0 O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl 10.1016/j.bmcl.2016.10.054
CHEMBL3984072 154096 None 0 Mouse Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 365 6 1 4 5.0 O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl 10.1016/j.bmcl.2016.10.054
73777069 142756 None 0 Mouse Functional pEC50 = 7.3 7.3 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3891920 142756 None 0 Mouse Functional pEC50 = 7.3 7.3 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
134138318 148107 None 0 Human Functional pEC50 = 6.3 6.3 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 378 9 1 4 5.4 COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3934450 148107 None 0 Human Functional pEC50 = 6.3 6.3 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 378 9 1 4 5.4 COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 10.1016/j.bmcl.2016.10.054
134144000 150297 None 0 Mouse Functional pEC50 = 8.3 8.3 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3952043 150297 None 0 Mouse Functional pEC50 = 8.3 8.3 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
86281123 163843 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 439 7 1 3 5.7 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2018.02.013
CHEMBL4205429 163843 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 439 7 1 3 5.7 Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2018.02.013
137646553 158006 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 6 1 2 4.7 Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4084333 158006 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 6 1 2 4.7 Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
118707083 113072 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 325 4 1 3 3.8 COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311197 113072 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 325 4 1 3 3.8 COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1 10.1016/j.bmcl.2014.05.012
743974 113090 None 54 Human Functional pEC50 = 6.3 6.3 1 3
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311308 113090 None 54 Human Functional pEC50 = 6.3 6.3 1 3
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
137638995 157057 None 0 Human Functional pEC50 = 6.3 6.3 16 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4072885 157057 None 0 Human Functional pEC50 = 6.3 6.3 16 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F 10.1016/j.bmcl.2017.01.034
23136401 159228 None 0 Human Functional pEC50 = 6.3 6.3 7 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 8 1 3 5.4 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4097919 159228 None 0 Human Functional pEC50 = 6.3 6.3 7 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 8 1 3 5.4 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
145984445 165555 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 456 9 1 4 5.3 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4239572 165555 None 0 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 456 9 1 4 5.3 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
134138281 147874 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 410 7 1 6 3.9 COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3932664 147874 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 410 7 1 6 3.9 COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
90417978 162078 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4159180 162078 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
73777153 142910 None 0 Mouse Functional pEC50 = 7.3 7.3 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3893026 142910 None 0 Mouse Functional pEC50 = 7.3 7.3 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
216237 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
216237.0 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
2226 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
4110 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
443894 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
443894.0 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
CHEMBL344159 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
DB06212 3843 None 51 Human Functional pEC50 = 5.3 5.3 -724 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 448 3 2 3 5.7 Clc1ccc2c(c1)C(O)CCCN2C(=O)c1ccc(cc1C)NC(=O)c1ccccc1C 10.6019/CHEMBL5442687
57521918 76303 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 380 7 1 2 5.9 Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
CHEMBL2058531 76303 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 380 7 1 2 5.9 Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1 10.1021/jm300215x
54582150 61830 None 0 Human Functional pEC50 = 4.3 4.3 -22 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 331 7 2 2 5.0 O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1 10.1021/jm300215x
CHEMBL1773259 61830 None 0 Human Functional pEC50 = 4.3 4.3 -22 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 331 7 2 2 5.0 O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1 10.1021/jm300215x
59455584 157133 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 378 8 1 4 4.6 CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4073815 157133 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 378 8 1 4 4.6 CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
137646553 158006 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 6 1 2 4.7 Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4084333 158006 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 6 1 2 4.7 Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
134132951 144710 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 454 8 1 7 3.9 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3907996 144710 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 454 8 1 7 3.9 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
137638995 157057 None 0 Human Functional pEC50 = 6.3 6.3 16 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4072885 157057 None 0 Human Functional pEC50 = 6.3 6.3 16 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F 10.1016/j.bmcl.2017.01.034
90407027 164289 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 437 7 1 3 6.3 Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2018.02.013
CHEMBL4210752 164289 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 437 7 1 3 6.3 Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2018.02.013
54585039 61823 None 2 Human Functional pEC50 = 5.3 5.3 -17 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 334 6 1 2 4.0 O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1 10.1021/jm300215x
CHEMBL1773252 61823 None 2 Human Functional pEC50 = 5.3 5.3 -17 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 334 6 1 2 4.0 O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1 10.1021/jm300215x
134143899 150327 None 0 Human Functional pEC50 = 6.3 6.3 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 5 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3952316 150327 None 0 Human Functional pEC50 = 6.3 6.3 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 5 1 3 5.0 O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
87054900 148849 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3940493 148849 None 0 Human Functional pEC50 = 6.3 6.3 -1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 10.1016/j.bmcl.2016.10.054
90406418 164672 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 457 7 1 3 5.8 CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O 10.1016/j.bmcl.2018.02.013
CHEMBL4215446 164672 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 457 7 1 3 5.8 CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O 10.1016/j.bmcl.2018.02.013
134131620 142519 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 442 7 1 5 4.5 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3890035 142519 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 442 7 1 5 4.5 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
23136401 159228 None 0 Human Functional pEC50 = 6.3 6.3 7 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 8 1 3 5.4 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4097919 159228 None 0 Human Functional pEC50 = 6.3 6.3 7 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 362 8 1 3 5.4 Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 10.1016/j.bmcl.2017.01.034
90418513 162718 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 429 8 1 4 6.2 CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4169436 162718 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 429 8 1 4 6.2 CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
23136363 58850 None 0 Human Functional pEC50 = 6.3 6.3 -14 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 348 8 1 3 5.1 O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 10.1021/jm300215x
CHEMBL1688458 58850 None 0 Human Functional pEC50 = 6.3 6.3 -14 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 348 8 1 3 5.1 O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 10.1021/jm300215x
73777063 1154 None 36 Human Functional pEC50 = 5.3 5.3 -4 2
GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.6019/CHEMBL5442687
8418 1154 None 36 Human Functional pEC50 = 5.3 5.3 -4 2
GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.6019/CHEMBL5442687
CHEMBL3919973 1154 None 36 Human Functional pEC50 = 5.3 5.3 -4 2
GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in agonist mode with target: FFAR4
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.6019/CHEMBL5442687
134150245 152334 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 5.1 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3968947 152334 None 0 Human Functional pEC50 = 7.2 7.2 -6 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 5.1 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
137643146 158156 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 455 8 1 4 5.8 CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4086174 158156 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 455 8 1 4 5.8 CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
73777085 153319 None 0 Mouse Functional pEC50 = 6.2 6.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3977361 153319 None 0 Mouse Functional pEC50 = 6.2 6.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
73776997 154369 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 407 4 1 4 4.5 O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 10.1021/acsmedchemlett.6b00360
CHEMBL3986483 154369 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 407 4 1 4 4.5 O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 10.1021/acsmedchemlett.6b00360
23346507 88322 None 0 Human Functional pEC50 = 4.2 4.2 -30 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 255 6 2 2 3.3 O=C(O)CCc1ccc(NCc2ccccc2)cc1 10.1021/jm300215x
CHEMBL234834 88322 None 0 Human Functional pEC50 = 4.2 4.2 -30 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 255 6 2 2 3.3 O=C(O)CCc1ccc(NCc2ccccc2)cc1 10.1021/jm300215x
10223146 2155 None 46 Human Functional pEC50 = 6.2 6.2 -30 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 407 4 3 6 4.3 O=C(Nc1cc(Cl)nc(c1)Cl)NNc1cc(C(C)C)c2c(n1)n(C)nc2C 10.6019/CHEMBL5442687
2917 2155 None 46 Human Functional pEC50 = 6.2 6.2 -30 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 407 4 3 6 4.3 O=C(Nc1cc(Cl)nc(c1)Cl)NNc1cc(C(C)C)c2c(n1)n(C)nc2C 10.6019/CHEMBL5442687
CHEMBL1368758 2155 None 46 Human Functional pEC50 = 6.2 6.2 -30 5
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 407 4 3 6 4.3 O=C(Nc1cc(Cl)nc(c1)Cl)NNc1cc(C(C)C)c2c(n1)n(C)nc2C 10.6019/CHEMBL5442687
57521810 76292 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1 10.1021/jm300215x
CHEMBL2058521 76292 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 350 7 1 2 5.1 O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1 10.1021/jm300215x
24825484 88025 None 0 Human Functional pEC50 = 4.2 4.2 -208 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 331 7 2 2 5.0 O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1 10.1021/jm300215x
CHEMBL234269 88025 None 0 Human Functional pEC50 = 4.2 4.2 -208 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 331 7 2 2 5.0 O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1 10.1021/jm300215x
73777111 149798 None 0 Mouse Functional pEC50 = 6.2 6.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3947837 149798 None 0 Mouse Functional pEC50 = 6.2 6.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
137642184 158594 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 2 4 4.4 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4091118 158594 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 2 4 4.4 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 10.1016/j.bmcl.2017.01.034
134156727 153723 None 0 Mouse Functional pEC50 = 8.2 8.2 4 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3980898 153723 None 0 Mouse Functional pEC50 = 8.2 8.2 4 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
137637576 156154 None 0 Human Functional pEC50 = 7.2 7.2 63 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 298 6 1 2 4.2 Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4062640 156154 None 0 Human Functional pEC50 = 7.2 7.2 63 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 298 6 1 2 4.2 Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
137658634 159497 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4100773 159497 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 10.1016/j.bmcl.2017.01.034
137643146 158156 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 455 8 1 4 5.8 CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4086174 158156 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 455 8 1 4 5.8 CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1016/j.bmcl.2017.06.028
134144214 150446 None 0 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 8 1 3 5.7 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3953203 150446 None 0 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 384 8 1 3 5.7 O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
59455552 156132 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 384 7 1 4 4.7 Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4062462 156132 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 384 7 1 4 4.7 Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
134134229 143342 None 0 Human Functional pEC50 = 7.2 7.2 -1 3
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
CHEMBL3896657 143342 None 0 Human Functional pEC50 = 7.2 7.2 -1 3
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
134134229 143342 None 0 Human Functional pEC50 = 7.2 7.2 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3896657 143342 None 0 Human Functional pEC50 = 7.2 7.2 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
137637576 156154 None 0 Human Functional pEC50 = 7.2 7.2 63 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 298 6 1 2 4.2 Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4062640 156154 None 0 Human Functional pEC50 = 7.2 7.2 63 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 298 6 1 2 4.2 Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 10.1016/j.bmcl.2017.01.034
137658634 159497 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4100773 159497 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 342 8 1 3 4.7 Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 10.1016/j.bmcl.2017.01.034
57522038 3887 None 48 Human Functional pEC50 = 7.2 7.2 -13 3
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmc.2017.10.040
6490 3887 None 48 Human Functional pEC50 = 7.2 7.2 -13 3
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmc.2017.10.040
CHEMBL2058533 3887 None 48 Human Functional pEC50 = 7.2 7.2 -13 3
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmc.2017.10.040
137638911 156821 None 0 Human Functional pEC50 = 6.2 6.2 32 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4070298 156821 None 0 Human Functional pEC50 = 6.2 6.2 32 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
137656526 159847 None 0 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 356 7 1 3 4.9 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
CHEMBL4105013 159847 None 0 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 356 7 1 3 4.9 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
743974 113090 None 54 Mouse Functional pEC50 = 6.2 6.2 -3 3
Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311308 113090 None 54 Mouse Functional pEC50 = 6.2 6.2 -3 3
Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
46941175 61832 None 27 Human Functional pEC50 = 5.2 5.2 -331 3
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 345 7 2 2 5.3 Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 10.1021/jm3002026
CHEMBL1773261 61832 None 27 Human Functional pEC50 = 5.2 5.2 -331 3
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 345 7 2 2 5.3 Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 10.1021/jm3002026
46941175 61832 None 27 Human Functional pEC50 = 5.2 5.2 -331 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 345 7 2 2 5.3 Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
CHEMBL1773261 61832 None 27 Human Functional pEC50 = 5.2 5.2 -331 3
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 345 7 2 2 5.3 Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
3518281 113095 None 8 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 293 3 1 2 3.6 Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
CHEMBL3311317 113095 None 8 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 293 3 1 2 3.6 Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1 10.1016/j.bmcl.2014.05.012
137642184 158594 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 2 4 4.4 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4091118 158594 None 0 Human Functional pEC50 = 5.2 5.2 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 386 8 2 4 4.4 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 10.1016/j.bmcl.2017.01.034
145985122 166003 None 0 Human Functional pEC50 = 6.2 6.2 17 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 456 11 1 4 5.5 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4250132 166003 None 0 Human Functional pEC50 = 6.2 6.2 17 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 456 11 1 4 5.5 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
134147174 149791 None 0 Mouse Functional pEC50 = 7.2 7.2 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 6 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3947787 149791 None 0 Mouse Functional pEC50 = 7.2 7.2 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 6 1 3 5.7 O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 10.1016/j.bmcl.2016.10.054
134145412 149359 None 0 Human Functional pEC50 = 7.2 7.2 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 330 8 1 3 4.3 O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3944507 149359 None 0 Human Functional pEC50 = 7.2 7.2 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 330 8 1 3 4.3 O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
73777156 152804 None 0 Mouse Functional pEC50 = 7.2 7.2 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3973034 152804 None 0 Mouse Functional pEC50 = 7.2 7.2 1 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
134143163 145832 None 0 Mouse Functional pEC50 = 7.2 7.2 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 362 8 1 3 5.7 Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3916564 145832 None 0 Mouse Functional pEC50 = 7.2 7.2 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 362 8 1 3 5.7 Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 10.1016/j.bmcl.2016.10.054
137638911 156821 None 0 Human Functional pEC50 = 6.2 6.2 32 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4070298 156821 None 0 Human Functional pEC50 = 6.2 6.2 32 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 384 7 1 3 5.5 Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
134134149 143462 None 0 Mouse Functional pEC50 = 7.2 7.2 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3897776 143462 None 0 Mouse Functional pEC50 = 7.2 7.2 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 348 8 1 3 5.4 O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 10.1016/j.bmcl.2016.10.054
137640328 157076 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F 10.1016/j.bmcl.2017.06.028
CHEMBL4073078 157076 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F 10.1016/j.bmcl.2017.06.028
117886639 148538 None 0 Mouse Functional pEC50 = 6.2 6.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
CHEMBL3937916 148538 None 0 Mouse Functional pEC50 = 6.2 6.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
118184919 162968 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 468 7 1 5 5.6 N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4173280 162968 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 468 7 1 5 5.6 N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
54586984 61827 None 0 Human Functional pEC50 = 5.2 5.2 -34 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 323 6 2 2 4.3 O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1 10.1021/jm300215x
CHEMBL1773256 61827 None 0 Human Functional pEC50 = 5.2 5.2 -34 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 323 6 2 2 4.3 O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1 10.1021/jm300215x
134139171 146351 None 0 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 6 1 3 5.4 Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 10.1016/j.bmcl.2016.10.054
CHEMBL3920591 146351 None 0 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 350 6 1 3 5.4 Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 10.1016/j.bmcl.2016.10.054
137661886 159421 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 453 7 1 4 6.2 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4099943 159421 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 453 7 1 4 6.2 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C 10.1016/j.bmcl.2017.06.028
90418886 163015 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 423 9 1 4 6.1 CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4174122 163015 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 423 9 1 4 6.1 CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
137656526 159847 None 0 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 356 7 1 3 4.9 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
CHEMBL4105013 159847 None 0 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 356 7 1 3 4.9 O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
145985686 165525 None 0 Human Functional pEC50 = 7.2 7.2 354 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 358 7 1 3 4.2 COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1 10.1016/j.bmcl.2018.06.047
CHEMBL4238809 165525 None 0 Human Functional pEC50 = 7.2 7.2 354 2
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 358 7 1 3 4.2 COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1 10.1016/j.bmcl.2018.06.047
137648785 157702 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 427 7 1 4 5.2 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4080995 157702 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 427 7 1 4 5.2 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
134153986 152595 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3971308 152595 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134153562 152812 None 0 Mouse Functional pEC50 = 8.2 8.2 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 394 7 1 3 4.9 O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F 10.1016/j.bmcl.2016.10.054
CHEMBL3973101 152812 None 0 Mouse Functional pEC50 = 8.2 8.2 2 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 394 7 1 3 4.9 O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F 10.1016/j.bmcl.2016.10.054
134140073 146409 None 0 Mouse Functional pEC50 = 7.2 7.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.4 CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3921062 146409 None 0 Mouse Functional pEC50 = 7.2 7.2 1 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.4 CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O 10.1016/j.bmcl.2016.10.054
134135468 144563 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 389 4 1 3 4.8 O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3906716 144563 None 0 Human Functional pEC50 = 6.2 6.2 1 2
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 389 4 1 3 4.8 O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 10.1021/acsmedchemlett.6b00360
57521702 76289 None 0 Human Functional pEC50 = 5.2 5.2 -11 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1 10.1021/jm300215x
CHEMBL2058518 76289 None 0 Human Functional pEC50 = 5.2 5.2 -11 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1 10.1021/jm300215x
137636575 155991 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 479 7 1 4 6.0 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4060663 155991 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 479 7 1 4 6.0 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
137635671 156082 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
CHEMBL4061699 156082 None 0 Human Functional pEC50 = 7.2 7.2 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 461 7 1 4 5.9 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 10.1016/j.bmcl.2017.06.028
85471695 158761 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4092882 158761 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
85470884 164099 None 3 Rat Functional pEC50 = 6.2 6.2 -7 5
Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4208325 164099 None 3 Rat Functional pEC50 = 6.2 6.2 -7 5
Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
134155847 151191 None 0 Human Functional pEC50 = 7.1 7.1 63 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 418 5 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3959144 151191 None 0 Human Functional pEC50 = 7.1 7.1 63 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 418 5 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134132711 145026 None 0 Mouse Functional pEC50 = 7.1 7.1 -1 2
Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3910333 145026 None 0 Mouse Functional pEC50 = 7.1 7.1 -1 2
Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
137636167 156078 None 0 Human Functional pEC50 = 6.1 6.1 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O 10.1016/j.bmcl.2017.01.034
CHEMBL4061630 156078 None 0 Human Functional pEC50 = 6.1 6.1 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O 10.1016/j.bmcl.2017.01.034
134142450 145534 None 0 Mouse Functional pEC50 = 7.1 7.1 10 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.7 CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3914253 145534 None 0 Mouse Functional pEC50 = 7.1 7.1 10 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.7 CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
137660302 159532 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 413 8 1 4 5.8 CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4101135 159532 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 413 8 1 4 5.8 CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
90418333 162750 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 473 8 1 5 5.7 COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4169851 162750 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 473 8 1 5 5.7 COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
57522038 3887 None 48 Human Functional pEC50 = 7.1 7.1 -13 3
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmc.2017.10.040
6490 3887 None 48 Human Functional pEC50 = 7.1 7.1 -13 3
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmc.2017.10.040
CHEMBL2058533 3887 None 48 Human Functional pEC50 = 7.1 7.1 -13 3
Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmc.2017.10.040
57839754 157908 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 270 6 1 2 3.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 10.1016/j.bmcl.2017.01.034
CHEMBL4083325 157908 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 270 6 1 2 3.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 10.1016/j.bmcl.2017.01.034
90407037 157380 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 377 8 1 3 5.3 CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4076902 157380 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 377 8 1 3 5.3 CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
3893 2287 None 65 Human Functional pEC50 = 5.1 5.1 -10 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
4642 2287 None 65 Human Functional pEC50 = 5.1 5.1 -10 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
5534 2287 None 65 Human Functional pEC50 = 5.1 5.1 -10 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
CHEMBL108766 2287 None 65 Human Functional pEC50 = 5.1 5.1 -10 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
DB03017 2287 None 65 Human Functional pEC50 = 5.1 5.1 -10 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
59455555 158808 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 399 7 1 4 5.5 Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4093383 158808 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 399 7 1 4 5.5 Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
134149615 148664 None 0 Human Functional pEC50 = 7.1 7.1 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
CHEMBL3939004 148664 None 0 Human Functional pEC50 = 7.1 7.1 -1 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 370 5 1 3 4.6 O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1016/j.bmcl.2016.10.054
90418278 162473 None 16 Mouse Functional pEC50 = 7.1 7.1 -1 2
Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4165366 162473 None 16 Mouse Functional pEC50 = 7.1 7.1 -1 2
Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
134155277 151414 None 0 Mouse Functional pEC50 = 7.1 7.1 3 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl 10.1016/j.bmcl.2016.10.054
CHEMBL3961009 151414 None 0 Mouse Functional pEC50 = 7.1 7.1 3 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 388 7 1 3 5.5 Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl 10.1016/j.bmcl.2016.10.054
134133992 143826 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3900705 143826 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134133297 143866 None 0 Mouse Functional pEC50 = 7.1 7.1 3 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 372 7 1 3 4.9 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3900990 143866 None 0 Mouse Functional pEC50 = 7.1 7.1 3 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 372 7 1 3 4.9 Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
977153 51435 None 11 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 339 4 1 3 4.1 COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl 10.1016/j.bmcl.2014.05.012
CHEMBL1581959 51435 None 11 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 339 4 1 3 4.1 COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl 10.1016/j.bmcl.2014.05.012
137636167 156078 None 0 Human Functional pEC50 = 6.1 6.1 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O 10.1016/j.bmcl.2017.01.034
CHEMBL4061630 156078 None 0 Human Functional pEC50 = 6.1 6.1 2 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 370 7 1 3 5.2 Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O 10.1016/j.bmcl.2017.01.034
57839754 157908 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 270 6 1 2 3.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 10.1016/j.bmcl.2017.01.034
CHEMBL4083325 157908 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 270 6 1 2 3.6 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 10.1016/j.bmcl.2017.01.034
743974 113090 None 54 Rat Functional pEC50 = 6.1 6.1 -1 3
Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311308 113090 None 54 Rat Functional pEC50 = 6.1 6.1 -1 3
Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
8190702 113094 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 317 4 1 3 3.6 CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311316 113094 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR
ChEMBL 317 4 1 3 3.6 CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
85470884 164099 None 3 Human Functional pEC50 = 7.1 7.1 2 5
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4208325 164099 None 3 Human Functional pEC50 = 7.1 7.1 2 5
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
137634829 156163 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4062742 156163 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
134154417 152793 None 0 Mouse Functional pEC50 = 7.1 7.1 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3972973 152793 None 0 Mouse Functional pEC50 = 7.1 7.1 2 2
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
137631865 156425 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 399 7 1 4 5.5 Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4065769 156425 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 399 7 1 4 5.5 Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1016/j.bmcl.2017.06.028
134145750 149233 None 0 Human Functional pEC50 = 5.1 5.1 -3 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 324 6 1 2 4.6 O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3943430 149233 None 0 Human Functional pEC50 = 5.1 5.1 -3 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 324 6 1 2 4.6 O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 10.1016/j.bmcl.2016.10.054
134142450 145534 None 0 Human Functional pEC50 = 6.1 6.1 -10 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.7 CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3914253 145534 None 0 Human Functional pEC50 = 6.1 6.1 -10 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.7 CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
134140073 146409 None 0 Human Functional pEC50 = 7.1 7.1 -1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.4 CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3921062 146409 None 0 Human Functional pEC50 = 7.1 7.1 -1 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 382 5 1 3 5.4 CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O 10.1016/j.bmcl.2016.10.054
46892131 144759 None 3 Mouse Functional pEC50 = 7.1 7.1 3 2
Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3908362 144759 None 3 Mouse Functional pEC50 = 7.1 7.1 3 2
Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
51350138 58866 None 0 Human Functional pEC50 = 5.1 5.1 -660 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 378 7 1 2 5.7 Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
CHEMBL1688473 58866 None 0 Human Functional pEC50 = 5.1 5.1 -660 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 378 7 1 2 5.7 Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
86343792 164776 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 475 7 1 3 6.3 O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2018.02.013
CHEMBL4216937 164776 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 475 7 1 3 6.3 O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2018.02.013
60195038 81823 None 0 Human Functional pEC50 = 5.1 5.1 -912 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 363 7 2 2 5.4 Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
CHEMBL2164239 81823 None 0 Human Functional pEC50 = 5.1 5.1 -912 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 363 7 2 2 5.4 Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
85472487 162572 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4167097 162572 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
51350272 58858 None 0 Human Functional pEC50 = 5.1 5.1 -107 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
CHEMBL1688465 58858 None 0 Human Functional pEC50 = 5.1 5.1 -107 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 346 7 1 2 5.3 Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1 10.1021/jm300215x
145985219 165559 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 420 9 1 4 5.0 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4239630 165559 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 420 9 1 4 5.0 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1 10.1016/j.bmcl.2018.06.047
90406893 164530 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 454 8 1 4 5.3 CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 10.1016/j.bmcl.2018.02.013
CHEMBL4213710 164530 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 454 8 1 4 5.3 CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 10.1016/j.bmcl.2018.02.013
134148736 148642 None 0 Human Functional pEC50 = 7.1 7.1 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 383 8 1 4 5.4 O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3938783 148642 None 0 Human Functional pEC50 = 7.1 7.1 -2 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 383 8 1 4 5.4 O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
86281121 164107 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 451 7 1 3 6.4 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2018.02.013
CHEMBL4208442 164107 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 451 7 1 3 6.4 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2018.02.013
134138802 148007 None 0 Mouse Functional pEC50 = 7.1 7.1 4 2
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3933619 148007 None 0 Mouse Functional pEC50 = 7.1 7.1 4 2
Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
137649416 157611 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2017.01.034
CHEMBL4079893 157611 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 338 6 1 2 4.6 Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2017.01.034
134150245 152334 None 0 Mouse Functional pEC50 = 8.1 8.1 6 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 5.1 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3968947 152334 None 0 Mouse Functional pEC50 = 8.1 8.1 6 3
Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 374 7 1 3 5.1 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 10.1016/j.bmcl.2016.10.054
137657968 159686 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
CHEMBL4103081 159686 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 394 8 1 3 6.2 CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1016/j.bmcl.2017.06.028
90407263 163694 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F 10.1016/j.bmcl.2018.02.013
CHEMBL4203559 163694 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F 10.1016/j.bmcl.2018.02.013
57521917 76302 None 0 Human Functional pEC50 = 6.0 6.0 -8 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 366 7 1 2 5.6 O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1 10.1021/jm300215x
CHEMBL2058530 76302 None 0 Human Functional pEC50 = 6.0 6.0 -8 2
Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay
ChEMBL 366 7 1 2 5.6 O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1 10.1021/jm300215x
90418067 162425 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 425 9 1 5 5.6 CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4164722 162425 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 425 9 1 5 5.6 CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
86343790 164034 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 441 7 1 3 5.9 O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl 10.1016/j.bmcl.2018.02.013
CHEMBL4207603 164034 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay
ChEMBL 441 7 1 3 5.9 O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl 10.1016/j.bmcl.2018.02.013
145984796 165837 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 428 9 1 4 4.7 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
CHEMBL4246396 165837 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay
ChEMBL 428 9 1 4 4.7 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 10.1016/j.bmcl.2018.06.047
90405989 156051 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 383 7 1 3 5.3 Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
CHEMBL4061340 156051 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay
ChEMBL 383 7 1 3 5.3 Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C 10.1016/j.bmcl.2017.06.028
60195040 81825 None 0 Human Functional pEC50 = 4.0 4.0 -5248 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 377 7 2 2 5.7 Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
CHEMBL2164241 81825 None 0 Human Functional pEC50 = 4.0 4.0 -5248 2
Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization
ChEMBL 377 7 2 2 5.7 Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/jm3002026
134132142 144957 None 0 Human Functional pEC50 = 7.0 7.0 -13 2
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
CHEMBL3909872 144957 None 0 Human Functional pEC50 = 7.0 7.0 -13 2
Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
134132142 144957 None 0 Human Functional pEC50 = 7.0 7.0 -13 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
CHEMBL3909872 144957 None 0 Human Functional pEC50 = 7.0 7.0 -13 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1016/j.bmcl.2016.10.054
145971522 163211 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL4177287 163211 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
1599 2341 None 28 Human Functional pEC50 = 6.0 6.0 -501 32
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
3955 2341 None 28 Human Functional pEC50 = 6.0 6.0 -501 32
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
3955.0 2341 None 28 Human Functional pEC50 = 6.0 6.0 -501 32
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
7215 2341 None 28 Human Functional pEC50 = 6.0 6.0 -501 32
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
CHEMBL841 2341 None 28 Human Functional pEC50 = 6.0 6.0 -501 32
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
DB00836 2341 None 28 Human Functional pEC50 = 6.0 6.0 -501 32
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 10.6019/CHEMBL5442687
134142866 145730 None 0 Human Functional pEC50 = 6.0 6.0 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 358 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
CHEMBL3915765 145730 None 0 Human Functional pEC50 = 6.0 6.0 -2 3
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 358 7 1 3 4.6 O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 10.1016/j.bmcl.2016.10.054
57522038 3887 None 48 Human Functional pEC50 = 7.0 7.0 -13 3
Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
6490 3887 None 48 Human Functional pEC50 = 7.0 7.0 -13 3
Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
CHEMBL2058533 3887 None 48 Human Functional pEC50 = 7.0 7.0 -13 3
Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1021/jm300215x
137634844 156207 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 412 9 1 3 6.1 CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
CHEMBL4063239 156207 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 412 9 1 3 6.1 CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F 10.1016/j.bmcl.2017.01.034
23136363 58850 None 0 Human Functional pEC50 = 6.0 6.0 -14 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 348 8 1 3 5.1 O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 10.1016/j.bmcl.2017.01.034
CHEMBL1688458 58850 None 0 Human Functional pEC50 = 6.0 6.0 -14 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 348 8 1 3 5.1 O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 10.1016/j.bmcl.2017.01.034
134141029 147255 None 0 Human Functional pEC50 = 7.0 7.0 -4 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 352 6 1 3 4.8 O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
CHEMBL3927879 147255 None 0 Human Functional pEC50 = 7.0 7.0 -4 2
Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay
ChEMBL 352 6 1 3 4.8 O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 10.1016/j.bmcl.2016.10.054
82051616 159551 None 0 Human Functional pEC50 = 6.0 6.0 12 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl 10.1016/j.bmcl.2017.01.034
CHEMBL4101323 159551 None 0 Human Functional pEC50 = 6.0 6.0 12 2
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 304 6 1 2 4.2 Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl 10.1016/j.bmcl.2017.01.034
73777063 1154 None 36 Human Functional pEC50 = 7.0 7.0 -4 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
8418 1154 None 36 Human Functional pEC50 = 7.0 7.0 -4 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
CHEMBL3919973 1154 None 36 Human Functional pEC50 = 7.0 7.0 -4 2
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
85472618 162404 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 491 7 1 4 6.7 Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4164509 162404 None 0 Human Functional pEC50 = 7 7.0 - 1
Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay
ChEMBL 491 7 1 4 6.7 Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F 10.1021/acsmedchemlett.7b00233
137640323 157070 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 358 7 1 4 4.3 O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
CHEMBL4073013 157070 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay
ChEMBL 358 7 1 4 4.3 O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 10.1016/j.bmcl.2017.01.034
1692 2154 None 25 Human Functional pIC50 = 5.0 5.0 -338 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 411 6 2 4 5.5 CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C 10.6019/CHEMBL5442687
5311340 2154 None 25 Human Functional pIC50 = 5.0 5.0 -338 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 411 6 2 4 5.5 CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C 10.6019/CHEMBL5442687
CHEMBL140979 2154 None 25 Human Functional pIC50 = 5.0 5.0 -338 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 411 6 2 4 5.5 CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C 10.6019/CHEMBL5442687
233085 113086 None 38 Human Functional pIC50 = 5.8 5.8 -43 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.6019/CHEMBL5442687
CHEMBL3311302 113086 None 38 Human Functional pIC50 = 5.8 5.8 -43 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.6019/CHEMBL5442687
28 3496 None 35 Human Functional pIC50 = 5.5 5.5 1 15
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 10.6019/CHEMBL5442687
3292447 3496 None 35 Human Functional pIC50 = 5.5 5.5 1 15
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 10.6019/CHEMBL5442687
CHEMBL20963 3496 None 35 Human Functional pIC50 = 5.5 5.5 1 15
GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4GPCR PRESTO-Tango dose-response in antagonist mode with target: FFAR4
ChEMBL 486 9 1 7 5.2 COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C 10.6019/CHEMBL5442687
5588 1861 None 0 Human Functional pA2 = 5.0 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 372 9 3 3 6.1 C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C 19471906
9976563 1861 None 0 Human Functional pA2 = 5.0 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 372 9 3 3 6.1 C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C 19471906
CHEMBL513978 1861 None 0 Human Functional pA2 = 5.0 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 372 9 3 3 6.1 C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C 19471906
11531145 1862 None 0 Human Functional pA2 = 5.0 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 386 10 2 3 6.4 COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O 19471906
11531145 1862 None 0 Human Functional pA2 = 5.0 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 386 10 2 3 6.4 COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O 20685848
5589 1862 None 0 Human Functional pA2 = 5.0 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 386 10 2 3 6.4 COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O 19471906
5589 1862 None 0 Human Functional pA2 = 5.0 5.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 386 10 2 3 6.4 COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O 20685848
1054 2917 None 55 Human Functional pEC50 = 8.3 8.3 -1 5
NoneNone
Drug Central 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O None
3400 2917 None 55 Human Functional pEC50 = 8.3 8.3 -1 5
NoneNone
Drug Central 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O None
445639 2917 None 55 Human Functional pEC50 = 8.3 8.3 -1 5
NoneNone
Drug Central 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O None
CHEMBL8659 2917 None 55 Human Functional pEC50 = 8.3 8.3 -1 5
NoneNone
Drug Central 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O None
1052 2321 None 51 Human Functional pEC50 = 8.2 8.2 3 4
NoneNone
Drug Central 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O None
3323 2321 None 51 Human Functional pEC50 = 8.2 8.2 3 4
NoneNone
Drug Central 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O None
5280450 2321 None 51 Human Functional pEC50 = 8.2 8.2 3 4
NoneNone
Drug Central 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O None
CHEMBL267476 2321 None 51 Human Functional pEC50 = 8.2 8.2 3 4
NoneNone
Drug Central 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O None
DB14104 2321 None 51 Human Functional pEC50 = 8.2 8.2 3 4
NoneNone
Drug Central 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O None
11195 3882 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.
Guide to Pharmacology 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 27570890
86280676 3882 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.
Guide to Pharmacology 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 27570890
CHEMBL3941880 3882 None 0 Human Functional pEC50 = 6.6 6.6 1 2
Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.
Guide to Pharmacology 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 27570890
11195 3882 None 0 Mouse Functional pEC50 = 6.8 6.8 -1 2
Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.
Guide to Pharmacology 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 27570890
86280676 3882 None 0 Mouse Functional pEC50 = 6.8 6.8 -1 2
Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.
Guide to Pharmacology 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 27570890
CHEMBL3941880 3882 None 0 Mouse Functional pEC50 = 6.8 6.8 -1 2
Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.
Guide to Pharmacology 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 27570890
73777063 1154 None 36 Human Functional pEC50 = 7.6 7.6 -4 2
Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.
Guide to Pharmacology 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 24997608
8418 1154 None 36 Human Functional pEC50 = 7.6 7.6 -4 2
Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.
Guide to Pharmacology 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 24997608
CHEMBL3919973 1154 None 36 Human Functional pEC50 = 7.6 7.6 -4 2
Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.
Guide to Pharmacology 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 24997608
1054 2917 None 55 Human Functional pEC50 = 4.7 4.7 -1 5
UnclassifiedUnclassified
Guide to Pharmacology 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 22282525
3400 2917 None 55 Human Functional pEC50 = 4.7 4.7 -1 5
UnclassifiedUnclassified
Guide to Pharmacology 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 22282525
445639 2917 None 55 Human Functional pEC50 = 4.7 4.7 -1 5
UnclassifiedUnclassified
Guide to Pharmacology 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 22282525
CHEMBL8659 2917 None 55 Human Functional pEC50 = 4.7 4.7 -1 5
UnclassifiedUnclassified
Guide to Pharmacology 282 15 1 1 6.1 CCCCCCCC/C=C\CCCCCCCC(=O)O 22282525
1049 363 None 48 Rat Functional pEC50 = 5.1 5.1 -4 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 18320172
4618 363 None 48 Rat Functional pEC50 = 5.1 5.1 -4 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 18320172
5280934 363 None 48 Rat Functional pEC50 = 5.1 5.1 -4 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 18320172
CHEMBL8739 363 None 48 Rat Functional pEC50 = 5.1 5.1 -4 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 18320172
DB00132 363 None 48 Rat Functional pEC50 = 5.1 5.1 -4 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 18320172
11005 2694 None 67 Human Functional pEC50 = 5.2 5.2 1 3
UnclassifiedUnclassified
Guide to Pharmacology 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 22282525
2806 2694 None 67 Human Functional pEC50 = 5.2 5.2 1 3
UnclassifiedUnclassified
Guide to Pharmacology 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 22282525
CHEMBL111077 2694 None 67 Human Functional pEC50 = 5.2 5.2 1 3
UnclassifiedUnclassified
Guide to Pharmacology 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 22282525
DB08231 2694 None 67 Human Functional pEC50 = 5.2 5.2 1 3
UnclassifiedUnclassified
Guide to Pharmacology 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 22282525
1050 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
UnclassifiedUnclassified
Guide to Pharmacology 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 16702987
1050 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
UnclassifiedUnclassified
Guide to Pharmacology 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 18827341
11595431 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
UnclassifiedUnclassified
Guide to Pharmacology 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 16702987
11595431 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
UnclassifiedUnclassified
Guide to Pharmacology 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 18827341
CHEMBL207881 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
UnclassifiedUnclassified
Guide to Pharmacology 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 16702987
CHEMBL207881 1902 None 58 Human Functional pEC50 = 5.5 5.5 -26 3
UnclassifiedUnclassified
Guide to Pharmacology 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 18827341
1049 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 22519963
4618 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 22519963
5280934 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 22519963
CHEMBL8739 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 22519963
DB00132 363 None 48 Human Functional pEC50 = 5.5 5.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 278 13 1 1 5.7 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O 22519963
1052 2321 None 51 Human Functional pEC50 = 5.9 5.9 3 4
UnclassifiedUnclassified
Guide to Pharmacology 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 16702987
3323 2321 None 51 Human Functional pEC50 = 5.9 5.9 3 4
UnclassifiedUnclassified
Guide to Pharmacology 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 16702987
5280450 2321 None 51 Human Functional pEC50 = 5.9 5.9 3 4
UnclassifiedUnclassified
Guide to Pharmacology 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 16702987
CHEMBL267476 2321 None 51 Human Functional pEC50 = 5.9 5.9 3 4
UnclassifiedUnclassified
Guide to Pharmacology 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 16702987
DB14104 2321 None 51 Human Functional pEC50 = 5.9 5.9 3 4
UnclassifiedUnclassified
Guide to Pharmacology 280 14 1 1 5.9 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O 16702987
25098573 2747 None 10 Human Functional pEC50 = 5.9 5.9 8 2
UnclassifiedUnclassified
Guide to Pharmacology 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 19007110
5587 2747 None 10 Human Functional pEC50 = 5.9 5.9 8 2
UnclassifiedUnclassified
Guide to Pharmacology 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 19007110
CHEMBL463785 2747 None 10 Human Functional pEC50 = 5.9 5.9 8 2
UnclassifiedUnclassified
Guide to Pharmacology 376 10 1 4 4.7 OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 19007110


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
134154473 152463 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 370 6 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3970238 152463 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 370 6 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
73776979 143446 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 5 1 3 5.9 O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3897637 143446 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 5 1 3 5.9 O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
137638318 156826 None 0 Mouse Binding pEC50 = 6 6.0 - 1
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 402 4 1 5 4.4 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 10.1021/acs.jmedchem.7b00210
CHEMBL4070359 156826 None 0 Mouse Binding pEC50 = 6 6.0 - 1
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 402 4 1 5 4.4 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 10.1021/acs.jmedchem.7b00210
171351623 193594 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 484 10 2 8 3.7 Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5266523 193594 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 484 10 2 8 3.7 Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
171342834 193713 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5269688 193713 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
171354496 194105 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5278791 194105 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
171348900 194335 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 466 8 2 7 4.3 Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5283726 194335 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 466 8 2 7 4.3 Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
127031569 139271 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 264 4 1 1 3.3 O=C(O)CCc1ccc(C#CCc2ccccc2)cc1 10.1021/acs.jmedchem.5b01962
CHEMBL3787580 139271 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 264 4 1 1 3.3 O=C(O)CCc1ccc(C#CCc2ccccc2)cc1 10.1021/acs.jmedchem.5b01962
145971522 163211 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL4177287 163211 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
134129938 142527 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 414 6 1 4 5.0 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3890089 142527 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 414 6 1 4 5.0 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
156011529 177502 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 420 7 1 3 6.2 CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1 10.1016/j.bmc.2019.115263
CHEMBL4638249 177502 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 420 7 1 3 6.2 CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1 10.1016/j.bmc.2019.115263
134132142 144957 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
CHEMBL3909872 144957 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
73777175 143996 None 0 Mouse Binding pEC50 = 6.0 6.0 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3901994 143996 None 0 Mouse Binding pEC50 = 6.0 6.0 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
85472621 162898 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4172392 162898 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
66562488 90405 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 336 4 1 1 4.3 O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F 10.1021/ml4000673
CHEMBL2386364 90405 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 336 4 1 1 4.3 O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F 10.1021/ml4000673
171352188 193918 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 492 6 2 7 4.9 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5274344 193918 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 492 6 2 7 4.9 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
164888199 194467 None 2 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulation
ChEMBL 362 3 0 4 3.6 C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.0c01002
CHEMBL5286838 194467 None 2 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulation
ChEMBL 362 3 0 4 3.6 C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.0c01002
73777153 142910 None 0 Mouse Binding pEC50 = 6.9 6.9 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3893026 142910 None 0 Mouse Binding pEC50 = 6.9 6.9 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
171353999 194022 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 417 6 2 8 4.3 Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12 10.1021/acsmedchemlett.2c00160
CHEMBL5276740 194022 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 417 6 2 8 4.3 Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12 10.1021/acsmedchemlett.2c00160
171355332 194219 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 442 6 2 7 4.0 Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5281423 194219 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 442 6 2 7 4.0 Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
171349936 194525 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 482 9 2 8 3.9 COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5288340 194525 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 482 9 2 8 3.9 COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1 10.1021/acsmedchemlett.2c00160
137640163 156940 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 372 5 1 5 4.4 Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12 10.1021/acs.jmedchem.7b00210
CHEMBL4071523 156940 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 372 5 1 5 4.4 Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12 10.1021/acs.jmedchem.7b00210
7614387 194382 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 389 5 2 8 3.5 Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1 10.1021/acsmedchemlett.2c00160
CHEMBL5284985 194382 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 389 5 2 8 3.5 Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1 10.1021/acsmedchemlett.2c00160
11195 3882 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
86280676 3882 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
CHEMBL3941880 3882 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
171354782 193990 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assay
ChEMBL 462 7 1 3 6.9 OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F 10.1021/acs.jmedchem.0c01002
CHEMBL5275980 193990 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assay
ChEMBL 462 7 1 3 6.9 OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F 10.1021/acs.jmedchem.0c01002
134153222 152614 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3971461 152614 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 10.1021/acs.jmedchem.6b00685
171348041 194458 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 457 5 2 8 4.8 Cc1c(Cl)cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5286544 194458 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 457 5 2 8 4.8 Cc1c(Cl)cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
11195 3882 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
86280676 3882 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
CHEMBL3941880 3882 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
145955668 162520 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 415 7 1 4 6.0 Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL4166208 162520 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 415 7 1 4 6.0 Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C 10.1021/acsmedchemlett.7b00233
162644046 181916 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 361 4 2 5 3.0 Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
CHEMBL4778107 181916 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 361 4 2 5 3.0 Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
134146720 149219 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 443 7 1 6 5.6 COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3943315 149219 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 443 7 1 6 5.6 COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
134146958 149697 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 388 6 1 3 5.1 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3947070 149697 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 388 6 1 3 5.1 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134147601 150116 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3950444 150116 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
90418139 162676 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 443 7 1 4 5.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4168786 162676 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 443 7 1 4 5.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
8357996 193835 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 403 6 2 8 3.8 CCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12 10.1021/acsmedchemlett.2c00160
CHEMBL5272492 193835 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 403 6 2 8 3.8 CCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12 10.1021/acsmedchemlett.2c00160
90418650 157447 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL4077787 157447 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 401 7 1 4 5.7 Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C 10.1021/acsmedchemlett.7b00233
134132711 145026 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3910333 145026 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
73345869 90396 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 321 5 1 2 3.7 N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
CHEMBL2386355 90396 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 321 5 1 2 3.7 N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
171354164 194204 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 442 6 2 7 4.0 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3F)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5281020 194204 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 442 6 2 7 4.0 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3F)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
134133992 143826 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3900705 143826 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
73777135 150458 None 0 Mouse Binding pEC50 = 6.9 6.9 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3953289 150458 None 0 Mouse Binding pEC50 = 6.9 6.9 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
73777175 143996 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3901994 143996 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 357 3 1 2 4.9 O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 10.1021/acsmedchemlett.6b00360
171348401 194489 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 448 9 2 8 3.1 COc1ccccc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1 10.1021/acsmedchemlett.2c00160
CHEMBL5287358 194489 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 448 9 2 8 3.1 COc1ccccc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1 10.1021/acsmedchemlett.2c00160
171351236 194531 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 448 9 2 8 3.1 COc1cccc(CCNc2nc(N)nc(COc3cc(C)cc(N4CCCC4=O)c3)n2)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5288405 194531 None 0 Human Binding pEC50 = 4.9 4.9 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 448 9 2 8 3.1 COc1cccc(CCNc2nc(N)nc(COc3cc(C)cc(N4CCCC4=O)c3)n2)c1 10.1021/acsmedchemlett.2c00160
90418653 137600 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C 10.1021/acsmedchemlett.7b00233
CHEMBL3754160 137600 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 469 7 1 4 6.7 Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C 10.1021/acsmedchemlett.7b00233
90418278 162473 None 16 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4165366 162473 None 16 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
171357993 194299 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 449 6 2 8 3.7 Cc1ccc(Nc2nc(N)nc(COc3cc(C#N)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5283217 194299 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 449 6 2 8 3.7 Cc1ccc(Nc2nc(N)nc(COc3cc(C#N)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
171352664 194070 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.2 Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3C)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5277986 194070 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.2 Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3C)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
25150014 3885 None 44 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 264 3 1 1 3.4 OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C 10.1021/ml4000673
3952 3885 None 44 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 264 3 1 1 3.4 OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C 10.1021/ml4000673
CHEMBL449588 3885 None 44 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 264 3 1 1 3.4 OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C 10.1021/ml4000673
171349259 193609 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 458 6 2 7 4.5 Cc1ccc(Nc2nc(N)nc(COc3cc(Cl)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5266881 193609 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 458 6 2 7 4.5 Cc1ccc(Nc2nc(N)nc(COc3cc(Cl)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
171358500 194625 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 423 5 2 8 4.2 Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5290885 194625 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 423 5 2 8 4.2 Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
134151903 153445 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 438 6 1 6 4.2 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3978465 153445 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 438 6 1 6 4.2 COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
134133797 143655 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 338 3 0 4 3.6 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3899190 143655 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 338 3 0 4 3.6 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
162674347 183227 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 364 7 1 2 5.4 Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4794951 183227 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 364 7 1 2 5.4 Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1 10.1016/j.bmcl.2020.127650
90418651 162508 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 469 8 1 4 6.6 CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
CHEMBL4166012 162508 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 469 8 1 4 6.6 CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
171349824 194568 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 425 6 2 8 4.1 Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C(F)F)cc(=O)oc4c3)n2)cc1 10.1021/acsmedchemlett.2c00160
CHEMBL5289099 194568 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 425 6 2 8 4.1 Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C(F)F)cc(=O)oc4c3)n2)cc1 10.1021/acsmedchemlett.2c00160
57522038 3887 None 48 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmcl.2020.127650
6490 3887 None 48 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmcl.2020.127650
CHEMBL2058533 3887 None 48 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 364 7 1 2 5.4 OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C 10.1016/j.bmcl.2020.127650
66562385 90402 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 282 3 1 1 3.6 Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
CHEMBL2386361 90402 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 282 3 1 1 3.6 Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
134134229 143342 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
CHEMBL3896657 143342 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
134138802 148007 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3933619 148007 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
134145071 150255 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 380 3 0 4 4.2 N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3951664 150255 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 380 3 0 4 4.2 N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.6b00685
171354782 193990 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulation
ChEMBL 462 7 1 3 6.9 OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F 10.1021/acs.jmedchem.0c01002
CHEMBL5275980 193990 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulation
ChEMBL 462 7 1 3 6.9 OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F 10.1021/acs.jmedchem.0c01002
171357390 194099 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.3 Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5278703 194099 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.3 Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
134152545 153566 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 380 3 0 4 4.2 N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3979588 153566 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 380 3 0 4 4.2 N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
134154975 151489 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 362 5 1 4 4.0 O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3961620 151489 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 362 5 1 4 4.0 O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1 10.1021/acs.jmedchem.6b00685
90418513 162718 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 429 8 1 4 6.2 CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4169436 162718 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 429 8 1 4 6.2 CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
134155950 151179 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 430 6 1 4 4.6 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3959068 151179 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 430 6 1 4 4.6 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 10.1021/acsmedchemlett.6b00394
134155847 151191 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 418 5 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3959144 151191 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 418 5 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134155480 151340 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3960231 151340 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
137654131 159106 None 0 Mouse Binding pEC50 = 7.8 7.8 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 416 5 1 4 5.3 COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
CHEMBL4096579 159106 None 0 Mouse Binding pEC50 = 7.8 7.8 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 416 5 1 4 5.3 COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
134143370 145891 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 442 7 1 6 4.0 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3916986 145891 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 442 7 1 6 4.0 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 10.1021/acsmedchemlett.6b00394
171358383 194614 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 432 8 2 7 3.4 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5290651 194614 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 432 8 2 7 3.4 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
127031003 139231 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 232 3 1 1 2.8 C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
CHEMBL3787072 139231 None 0 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 232 3 1 1 2.8 C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
8452407 180492 None 3 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 293 4 2 5 2.0 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] 10.1016/j.bmcl.2020.127650
CHEMBL4751828 180492 None 3 Human Binding pEC50 = 4.8 4.8 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 293 4 2 5 2.0 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] 10.1016/j.bmcl.2020.127650
78426052 178197 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 489 7 1 4 6.4 Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1 10.1016/j.bmc.2019.115263
CHEMBL4647832 178197 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 489 7 1 4 6.4 Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1 10.1016/j.bmc.2019.115263
171346217 194474 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.2 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5286962 194474 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.2 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
90418782 163178 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 513 7 1 4 6.6 O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4176642 163178 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 513 7 1 4 6.6 O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
73777153 142910 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3893026 142910 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 355 3 1 2 5.2 O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 10.1021/acsmedchemlett.6b00360
66562288 139096 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 246 3 1 1 3.2 C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
CHEMBL3785637 139096 None 0 Human Binding pEC50 = 4.7 4.7 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 246 3 1 1 3.2 C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
167312323 194388 None 1 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)ccc3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5285139 194388 None 1 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)ccc3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
137633489 156691 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 368 5 1 5 4.0 N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 10.1021/acs.jmedchem.7b00210
CHEMBL4068825 156691 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 368 5 1 5 4.0 N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 10.1021/acs.jmedchem.7b00210
134148110 149658 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3946820 149658 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
134134229 143342 None 0 Mouse Binding pEC50 = 7.7 7.7 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
CHEMBL3896657 143342 None 0 Mouse Binding pEC50 = 7.7 7.7 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 368 5 1 3 5.2 O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 10.1021/acsmedchemlett.6b00360
90418753 162491 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 463 8 1 4 6.6 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4165803 162491 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 463 8 1 4 6.6 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 10.1021/acsmedchemlett.7b00233
73776997 154369 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 407 4 1 4 4.5 O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 10.1021/acsmedchemlett.6b00360
CHEMBL3986483 154369 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 407 4 1 4 4.5 O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 10.1021/acsmedchemlett.6b00360
16777240 179885 None 1 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 330 3 2 3 3.4 Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4744629 179885 None 1 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 330 3 2 3 3.4 Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
171354494 194104 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 508 7 2 8 4.8 Cc1ccc(Nc2nc(N)nc(COc3cc(OC(F)(F)F)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5278789 194104 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 508 7 2 8 4.8 Cc1ccc(Nc2nc(N)nc(COc3cc(OC(F)(F)F)cc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
156016724 177822 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assayAgonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assay
ChEMBL 378 7 1 3 5.5 O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 10.1016/j.ejmech.2018.04.061
CHEMBL4642294 177822 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assayAgonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assay
ChEMBL 378 7 1 3 5.5 O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 10.1016/j.ejmech.2018.04.061
156016724 177822 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)
ChEMBL 378 7 1 3 5.5 O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 10.1016/j.bmc.2019.115263
CHEMBL4642294 177822 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)
ChEMBL 378 7 1 3 5.5 O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 10.1016/j.bmc.2019.115263
73777111 149798 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3947837 149798 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
134153546 152670 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3971857 152670 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 371 6 1 4 4.4 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
137633536 156386 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
CHEMBL4065397 156386 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
134145778 149435 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 355 3 0 3 4.3 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3945213 149435 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 355 3 0 3 4.3 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
134156727 153723 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3980898 153723 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
137650498 157414 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 382 5 1 5 4.3 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4077353 157414 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 382 5 1 5 4.3 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12 10.1021/acs.jmedchem.7b00210
134134846 144327 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 337 3 0 3 4.2 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3904654 144327 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 337 3 0 3 4.2 O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 10.1021/acs.jmedchem.6b00685
137641818 158299 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 373 6 1 5 4.1 COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4087992 158299 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 373 6 1 5 4.1 COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
73777085 153319 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3977361 153319 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
171346891 194387 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)cc3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5285104 194387 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)cc3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
137651638 157313 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 371 6 1 4 4.8 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4076190 157313 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 371 6 1 4 4.8 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
137646368 158120 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 358 5 1 5 3.8 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12 10.1021/acs.jmedchem.7b00210
CHEMBL4085695 158120 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 358 5 1 5 3.8 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12 10.1021/acs.jmedchem.7b00210
134154953 151365 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 369 3 0 3 4.6 Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3960369 151365 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 369 3 0 3 4.6 Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
66562289 139106 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 246 3 1 1 3.2 C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
CHEMBL3785764 139106 None 0 Human Binding pEC50 = 4.6 4.6 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 246 3 1 1 3.2 C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
134153067 152345 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 369 3 0 3 4.6 Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3969073 152345 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 369 3 0 3 4.6 Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.6b00685
78425909 177779 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 398 8 1 3 6.1 O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2 10.1016/j.bmc.2019.115263
CHEMBL4641735 177779 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 398 8 1 3 6.1 O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2 10.1016/j.bmc.2019.115263
117873187 152433 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 4 1 3 5.7 CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3969920 152433 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 4 1 3 5.7 CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
73777156 152804 None 0 Mouse Binding pEC50 = 6.5 6.5 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3973034 152804 None 0 Mouse Binding pEC50 = 6.5 6.5 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
171350458 193622 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 436 8 2 7 3.3 Cc1cc(OCc2nc(N)nc(NCCc3cccc(F)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5267225 193622 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 436 8 2 7 3.3 Cc1cc(OCc2nc(N)nc(NCCc3cccc(F)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
837245 10602 None 37 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 315 3 1 2 3.8 Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
CHEMBL1170012 10602 None 37 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 315 3 1 2 3.8 Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
73356514 90409 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 404 8 1 4 2.8 CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
CHEMBL2386368 90409 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 404 8 1 4 2.8 CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
73345870 90410 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 404 8 1 4 2.8 CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
CHEMBL2386369 90410 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 404 8 1 4 2.8 CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
73354950 90412 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 418 9 1 4 3.2 CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
CHEMBL2386370 90412 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 418 9 1 4 3.2 CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
73348895 90413 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 418 9 1 4 3.2 CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
CHEMBL2386371 90413 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 418 9 1 4 3.2 CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
171343639 193687 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 452 8 2 7 3.8 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5268800 193687 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 452 8 2 7 3.8 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
73777111 149798 None 0 Mouse Binding pEC50 = 5.5 5.5 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3947837 149798 None 0 Mouse Binding pEC50 = 5.5 5.5 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 373 3 1 2 5.1 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
171358819 194593 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 458 6 2 7 4.5 Cc1ccc(Nc2nc(N)nc(COc3ccc(Cl)c(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5289929 194593 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 458 6 2 7 4.5 Cc1ccc(Nc2nc(N)nc(COc3ccc(Cl)c(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
156635006 179646 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 400 4 2 4 4.0 Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
CHEMBL4741544 179646 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 400 4 2 4 4.0 Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
117886639 148538 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
CHEMBL3937916 148538 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
171344695 193701 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 7 2 8 3.9 COc1ccc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc1N1CCCC1=O 10.1021/acsmedchemlett.2c00160
CHEMBL5269158 193701 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 7 2 8 3.9 COc1ccc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc1N1CCCC1=O 10.1021/acsmedchemlett.2c00160
66562392 90406 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 336 3 1 1 4.6 O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F 10.1021/ml4000673
CHEMBL2386365 90406 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 336 3 1 1 4.6 O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F 10.1021/ml4000673
134138281 147874 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 410 7 1 6 3.9 COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3932664 147874 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 410 7 1 6 3.9 COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
134138802 148007 None 0 Mouse Binding pEC50 = 6.5 6.5 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3933619 148007 None 0 Mouse Binding pEC50 = 6.5 6.5 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 383 4 1 3 4.7 O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 10.1021/acsmedchemlett.6b00360
134153986 152595 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3971308 152595 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 3 4.8 O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
117886649 152167 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 391 4 1 3 5.4 OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3967504 152167 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 391 4 1 3 5.4 OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
171347514 194479 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 418 8 2 7 3.1 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5287009 194479 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 418 8 2 7 3.1 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
118184919 162968 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 468 7 1 5 5.6 N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4173280 162968 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 468 7 1 5 5.6 N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
127030344 139232 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 242 3 1 1 3.2 O=C(O)CCc1ccc(C#CC2CCCC2)cc1 10.1021/acs.jmedchem.5b01962
CHEMBL3787110 139232 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 242 3 1 1 3.2 O=C(O)CCc1ccc(C#CC2CCCC2)cc1 10.1021/acs.jmedchem.5b01962
127031002 139174 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 232 3 1 1 2.8 C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
CHEMBL3786526 139174 None 0 Human Binding pEC50 = 4.5 4.5 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 232 3 1 1 2.8 C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/acs.jmedchem.5b01962
134132142 144957 None 0 Mouse Binding pEC50 = 7.5 7.5 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
CHEMBL3909872 144957 None 0 Mouse Binding pEC50 = 7.5 7.5 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 402 7 1 3 5.8 Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O 10.1021/acsmedchemlett.6b00360
1050 1902 None 58 Human Binding pEC50 = 5.5 5.5 - 2
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1021/acs.jmedchem.0c01002
11595431 1902 None 58 Human Binding pEC50 = 5.5 5.5 - 2
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1021/acs.jmedchem.0c01002
CHEMBL207881 1902 None 58 Human Binding pEC50 = 5.5 5.5 - 2
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 347 8 2 3 5.1 OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 10.1021/acs.jmedchem.0c01002
674995 143091 None 9 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 343 5 1 3 4.4 O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3894632 143091 None 9 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 343 5 1 3 4.4 O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1 10.1021/acs.jmedchem.6b00685
162672256 182978 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 346 4 2 4 3.1 COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4791789 182978 None 0 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 346 4 2 4 3.1 COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
171355610 194097 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 443 5 2 8 4.5 Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(Cl)c(Cl)c4)n3)ccc12 10.1021/acsmedchemlett.2c00160
CHEMBL5278642 194097 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 443 5 2 8 4.5 Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(Cl)c(Cl)c4)n3)ccc12 10.1021/acsmedchemlett.2c00160
137648938 157504 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 382 4 1 3 5.5 Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4078553 157504 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 382 4 1 3 5.5 Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
73777156 152804 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3973034 152804 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 396 4 1 4 4.7 N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 10.1021/acsmedchemlett.6b00360
171345288 194304 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 502 9 2 8 4.0 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3OC(F)(F)F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5283269 194304 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 502 9 2 8 4.0 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3OC(F)(F)F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
71655293 90395 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 307 4 1 2 3.3 N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
CHEMBL2386354 90395 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 307 4 1 2 3.3 N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
71655227 90403 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 282 3 1 1 3.6 Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
CHEMBL2386362 90403 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 282 3 1 1 3.6 Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
134147107 149964 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 417 3 1 3 5.5 O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3949142 149964 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 417 3 1 3 5.5 O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 10.1021/acsmedchemlett.6b00360
156635004 179818 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 344 4 2 3 3.7 CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4743951 179818 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 344 4 2 3 3.7 CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
162674533 183571 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 372 3 2 3 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4799103 183571 None 0 Human Binding pEC50 = 4.4 4.4 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 372 3 2 3 4.4 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2020.127650
134144000 150297 None 0 Mouse Binding pEC50 = 8.3 8.3 - 0
Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3952043 150297 None 0 Mouse Binding pEC50 = 8.3 8.3 - 0
Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
134132711 145026 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3910333 145026 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 372 3 0 4 4.2 O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 10.1021/acs.jmedchem.6b00685
171352518 193895 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 466 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(C)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5273939 193895 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 466 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(C)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
137660172 159206 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O 10.1021/acs.jmedchem.7b00210
CHEMBL4097652 159206 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O 10.1021/acs.jmedchem.7b00210
117886639 148538 None 0 Mouse Binding pEC50 = 5.4 5.4 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
CHEMBL3937916 148538 None 0 Mouse Binding pEC50 = 5.4 5.4 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 391 3 1 3 5.3 CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 10.1021/acsmedchemlett.6b00360
127033352 139107 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 272 8 1 1 4.4 CCCCCCCC#Cc1ccc(CCC(=O)O)cc1 10.1021/acs.jmedchem.5b01962
CHEMBL3785789 139107 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 272 8 1 1 4.4 CCCCCCCC#Cc1ccc(CCC(=O)O)cc1 10.1021/acs.jmedchem.5b01962
137658977 159197 None 0 Mouse Binding pEC50 = 6.4 6.4 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 385 5 1 5 4.3 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4097537 159197 None 0 Mouse Binding pEC50 = 6.4 6.4 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 385 5 1 5 4.3 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
137649363 157488 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 385 5 1 4 5.0 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4078374 157488 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 385 5 1 4 5.0 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
134146386 148995 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3941726 148995 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 384 5 1 3 5.0 O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 10.1021/acsmedchemlett.6b00394
73777174 150542 None 0 Mouse Binding pEC50 = 5.4 5.4 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3954140 150542 None 0 Mouse Binding pEC50 = 5.4 5.4 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
90442039 163004 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 509 7 1 4 7.1 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
CHEMBL4173940 163004 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 509 7 1 4 7.1 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F 10.1021/acsmedchemlett.7b00233
134132951 144710 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 454 8 1 7 3.9 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3907996 144710 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 454 8 1 7 3.9 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F 10.1021/acsmedchemlett.6b00394
137652399 157587 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O 10.1021/acs.jmedchem.7b00210
CHEMBL4079621 157587 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O 10.1021/acs.jmedchem.7b00210
46892131 144759 None 3 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3908362 144759 None 3 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
134138099 147910 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 369 3 0 3 4.6 Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3932897 147910 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 369 3 0 3 4.6 Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 10.1021/acs.jmedchem.6b00685
7614420 194588 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 375 5 2 8 3.2 Cc1ccc(Nc2nc(N)nc(COc3ccc4ccc(=O)oc4c3)n2)cc1 10.1021/acsmedchemlett.2c00160
CHEMBL5289774 194588 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 375 5 2 8 3.2 Cc1ccc(Nc2nc(N)nc(COc3ccc4ccc(=O)oc4c3)n2)cc1 10.1021/acsmedchemlett.2c00160
73507535 177569 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 391 6 1 3 5.5 O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1 10.1016/j.bmc.2019.115263
CHEMBL4639009 177569 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 391 6 1 3 5.5 O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1 10.1016/j.bmc.2019.115263
73777065 147344 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 4 1 3 5.7 CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3928591 147344 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 4 1 3 5.7 CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
137642248 158245 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 10.1021/acs.jmedchem.7b00210
CHEMBL4087308 158245 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 10.1021/acs.jmedchem.7b00210
137643731 158478 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 361 5 1 4 4.2 O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4089919 158478 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 361 5 1 4 4.2 O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1 10.1021/acs.jmedchem.7b00210
137658977 159197 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 385 5 1 5 4.3 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4097537 159197 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 385 5 1 5 4.3 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
73777069 142756 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3891920 142756 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
11195 3882 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
86280676 3882 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
CHEMBL3941880 3882 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay
ChEMBL 356 3 0 4 3.7 Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 10.1021/acs.jmedchem.6b00685
67072752 86563 None 0 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 289 4 1 2 3.2 N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 10.1021/jm301470a
CHEMBL2315528 86563 None 0 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 289 4 1 2 3.2 N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 10.1021/jm301470a
127033353 139238 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 278 5 1 1 3.7 O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1 10.1021/acs.jmedchem.5b01962
CHEMBL3787151 139238 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 278 5 1 1 3.7 O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1 10.1021/acs.jmedchem.5b01962
73777135 150458 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3953289 150458 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 412 4 1 4 5.4 N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
137632610 156437 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 368 5 1 5 4.0 N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4065890 156437 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 368 5 1 5 4.0 N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
743974 113090 None 54 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3311308 113090 None 54 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1021/acs.jmedchem.6b00685
162673626 183299 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 350 3 2 3 3.7 Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
CHEMBL4795755 183299 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 350 3 2 3 3.7 Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
134144000 150297 None 0 Human Binding pEC50 = 8.3 8.3 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3952043 150297 None 0 Human Binding pEC50 = 8.3 8.3 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 431 8 1 6 4.0 COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
164888199 194467 None 2 Human Binding pEC50 = 8.3 8.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assay
ChEMBL 362 3 0 4 3.6 C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.0c01002
CHEMBL5286838 194467 None 2 Human Binding pEC50 = 8.3 8.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assay
ChEMBL 362 3 0 4 3.6 C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.0c01002
134154415 152783 None 0 Human Binding pEC50 = 8.3 8.3 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 447 6 1 5 6.3 Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 10.1021/acsmedchemlett.6b00394
CHEMBL3972870 152783 None 0 Human Binding pEC50 = 8.3 8.3 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 447 6 1 5 6.3 Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 10.1021/acsmedchemlett.6b00394
118679768 177725 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assayAgonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assay
ChEMBL 390 9 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 10.1016/j.ejmech.2018.04.061
CHEMBL4641038 177725 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assayAgonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assay
ChEMBL 390 9 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 10.1016/j.ejmech.2018.04.061
118679768 177725 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 390 9 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 10.1016/j.bmc.2019.115263
CHEMBL4641038 177725 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 390 9 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 10.1016/j.bmc.2019.115263
118679768 177725 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay
ChEMBL 390 9 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 10.1021/acs.jmedchem.0c01002
CHEMBL4641038 177725 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay
ChEMBL 390 9 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 10.1021/acs.jmedchem.0c01002
118679791 193824 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay
ChEMBL 364 8 1 2 5.8 Cc1ccc(C2=C(COc3ccc(CCCC(=O)O)cc3)CCCC2)cc1 10.1021/acs.jmedchem.0c01002
CHEMBL5272316 193824 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay
ChEMBL 364 8 1 2 5.8 Cc1ccc(C2=C(COc3ccc(CCCC(=O)O)cc3)CCCC2)cc1 10.1021/acs.jmedchem.0c01002
118679744 194430 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay
ChEMBL 404 8 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc4c(c3)CCCC4)CCCC2)cc1 10.1021/acs.jmedchem.0c01002
CHEMBL5285896 194430 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay
ChEMBL 404 8 1 2 6.4 O=C(O)CCCc1ccc(OCC2=C(c3ccc4c(c3)CCCC4)CCCC2)cc1 10.1021/acs.jmedchem.0c01002
171342776 193659 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 8 2 7 3.4 Cc1cc(OCc2nc(N)nc(NCCc3cc(F)ccc3F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5268182 193659 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 8 2 7 3.4 Cc1cc(OCc2nc(N)nc(NCCc3cc(F)ccc3F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
46908122 151659 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 334 3 0 4 3.8 O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3963275 151659 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 334 3 0 4 3.8 O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1 10.1021/acs.jmedchem.6b00685
162676836 183609 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 332 3 3 4 2.8 Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
CHEMBL4799668 183609 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 332 3 3 4 2.8 Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
90418476 162881 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 511 7 1 4 6.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4172136 162881 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 511 7 1 4 6.7 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
137645249 157703 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 403 5 1 5 4.4 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
CHEMBL4080998 157703 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 403 5 1 5 4.4 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
137648938 157504 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 382 4 1 3 5.5 Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4078553 157504 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 382 4 1 3 5.5 Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
156635003 181042 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 394 3 2 3 3.9 Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
CHEMBL4758125 181042 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 394 3 2 3 3.9 Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
137657813 159868 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 400 4 1 3 5.6 Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4105241 159868 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 400 4 1 3 5.6 Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
134147328 150137 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 394 4 0 4 4.4 N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3950610 150137 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 394 4 0 4 4.4 N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
162649435 180146 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 288 6 1 2 3.7 Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4747554 180146 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 288 6 1 2 3.7 Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
73777085 153319 None 0 Mouse Binding pEC50 = 5.3 5.3 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
CHEMBL3977361 153319 None 0 Mouse Binding pEC50 = 5.3 5.3 - 0
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 351 4 1 3 4.6 COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 10.1021/acsmedchemlett.6b00360
171347136 194333 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 482 9 2 8 3.8 COc1ccc(Cl)cc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1 10.1021/acsmedchemlett.2c00160
CHEMBL5283683 194333 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 482 9 2 8 3.8 COc1ccc(Cl)cc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1 10.1021/acsmedchemlett.2c00160
2843133 147735 None 42 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 307 6 1 2 4.0 CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b00685
CHEMBL3931570 147735 None 42 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 307 6 1 2 4.0 CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b00685
73777063 1154 None 36 Mouse Binding pEC50 = 7.3 7.3 - 1
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
8418 1154 None 36 Mouse Binding pEC50 = 7.3 7.3 - 1
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
CHEMBL3919973 1154 None 36 Mouse Binding pEC50 = 7.3 7.3 - 1
Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
137657813 159868 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 400 4 1 3 5.6 Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4105241 159868 None 0 Mouse Binding pEC50 = 6.3 6.3 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 400 4 1 3 5.6 Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
171354473 194088 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5278391 194088 None 0 Human Binding pEC50 = 4.3 4.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
171346828 193862 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 437 6 2 8 4.4 CCc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5273250 193862 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 437 6 2 8 4.4 CCc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
134141650 146787 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 380 3 0 4 4.2 N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
CHEMBL3923955 146787 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay
ChEMBL 380 3 0 4 4.2 N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 10.1021/acs.jmedchem.6b00685
66562390 90399 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 268 3 1 1 3.2 O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1 10.1021/ml4000673
CHEMBL2386358 90399 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 268 3 1 1 3.2 O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1 10.1021/ml4000673
162645828 179769 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 352 6 1 2 4.2 O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4743323 179769 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 352 6 1 2 4.2 O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1 10.1016/j.bmcl.2020.127650
73776995 148830 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 4 1 3 5.7 CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3940359 148830 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 419 4 1 3 5.7 CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 10.1021/acsmedchemlett.6b00360
171357825 194101 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 424 6 2 7 3.9 Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5278718 194101 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 424 6 2 7 3.9 Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
90118275 177485 None 0 Human Binding pEC50 = 8.2 8.2 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 377 9 1 4 4.8 O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1 10.1016/j.bmc.2019.115263
CHEMBL4637969 177485 None 0 Human Binding pEC50 = 8.2 8.2 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 377 9 1 4 4.8 O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1 10.1016/j.bmc.2019.115263
156021563 178130 None 0 Human Binding pEC50 = 8.2 8.2 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 534 12 1 6 6.2 COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1 10.1016/j.bmc.2019.115263
CHEMBL4646784 178130 None 0 Human Binding pEC50 = 8.2 8.2 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 534 12 1 6 6.2 COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1 10.1016/j.bmc.2019.115263
134155067 151395 None 0 Human Binding pEC50 = 8.2 8.2 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 401 7 1 5 4.4 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3960738 151395 None 0 Human Binding pEC50 = 8.2 8.2 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 401 7 1 5 4.4 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
134156727 153723 None 0 Mouse Binding pEC50 = 8.2 8.2 - 0
Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
CHEMBL3980898 153723 None 0 Mouse Binding pEC50 = 8.2 8.2 - 0
Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 419 7 1 5 4.1 CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 10.1021/acsmedchemlett.6b00394
164888199 194467 None 2 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulation
ChEMBL 362 3 0 4 3.6 C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.0c01002
CHEMBL5286838 194467 None 2 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulation
ChEMBL 362 3 0 4 3.6 C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 10.1021/acs.jmedchem.0c01002
171342623 193668 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.2 Cc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5268316 193668 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 438 6 2 7 4.2 Cc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
171342052 193672 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 423 5 2 8 4.2 Cc1cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)ccc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5268389 193672 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 423 5 2 8 4.2 Cc1cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)ccc1Cl 10.1021/acsmedchemlett.2c00160
171346998 194496 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 7 2 8 3.9 COc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5287642 194496 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 7 2 8 3.9 COc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
137651358 157235 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 375 5 1 4 4.6 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4075162 157235 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 375 5 1 4 4.6 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12 10.1021/acs.jmedchem.7b00210
171355983 194108 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 452 8 2 7 3.8 Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5278836 194108 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 452 8 2 7 3.8 Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
162656082 180808 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 299 6 1 3 3.3 N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4755578 180808 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 299 6 1 3 3.3 N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
90405673 178115 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 489 7 1 3 6.0 OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 10.1016/j.bmc.2019.115263
CHEMBL4646553 178115 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)
ChEMBL 489 7 1 3 6.0 OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 10.1016/j.bmc.2019.115263
90417978 162078 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4159180 162078 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
137645249 157703 None 0 Mouse Binding pEC50 = 6.2 6.2 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 403 5 1 5 4.4 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
CHEMBL4080998 157703 None 0 Mouse Binding pEC50 = 6.2 6.2 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 403 5 1 5 4.4 COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
743974 113090 None 54 Mouse Binding pEC50 = 5.2 5.2 - 0
Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311308 113090 None 54 Mouse Binding pEC50 = 5.2 5.2 - 0
Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA
ChEMBL 305 4 1 3 3.4 COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 10.1016/j.bmcl.2014.05.012
81762207 182853 None 1 Human Binding pEC50 = 4.2 4.2 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 266 3 2 3 2.2 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F 10.1016/j.bmcl.2020.127650
CHEMBL4790052 182853 None 1 Human Binding pEC50 = 4.2 4.2 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 266 3 2 3 2.2 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F 10.1016/j.bmcl.2020.127650
171350799 193579 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 480 6 2 7 5.2 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)cc(C(C)(C)C)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
CHEMBL5266170 193579 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 480 6 2 7 5.2 Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)cc(C(C)(C)C)c3)n2)cc1Cl 10.1021/acsmedchemlett.2c00160
137649555 157422 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4077507 157422 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 357 5 1 4 4.4 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
137656733 159678 None 0 Mouse Binding pEC50 = 6.2 6.2 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 383 4 1 4 4.9 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4102951 159678 None 0 Mouse Binding pEC50 = 6.2 6.2 - 0
Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 383 4 1 4 4.9 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
66562388 90408 None 0 Human Binding pEC50 = 4.2 4.2 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 360 5 1 3 2.8 CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
CHEMBL2386367 90408 None 0 Human Binding pEC50 = 4.2 4.2 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 360 5 1 3 2.8 CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 10.1021/ml4000673
73777063 1154 None 36 Human Binding pEC50 = 7.2 7.2 - 1
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
8418 1154 None 36 Human Binding pEC50 = 7.2 7.2 - 1
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
CHEMBL3919973 1154 None 36 Human Binding pEC50 = 7.2 7.2 - 1
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 405 4 1 3 5.5 OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F 10.1021/acsmedchemlett.6b00360
85470884 164099 None 3 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
CHEMBL4208325 164099 None 3 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 459 7 1 3 6.0 O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 10.1016/j.bmcl.2018.02.013
137637713 155946 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 369 4 1 4 4.6 Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4060171 155946 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 369 4 1 4 4.6 Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
134133355 143623 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 413 6 1 5 4.2 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3898962 143623 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 413 6 1 5 4.2 COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
137633536 156386 None 0 Mouse Binding pEC50 = 7.2 7.2 - 0
Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
CHEMBL4065397 156386 None 0 Mouse Binding pEC50 = 7.2 7.2 - 0
Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor
ChEMBL 368 7 1 3 4.6 COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C 10.1016/j.bmcl.2017.01.034
73777069 142756 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3891920 142756 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 389 4 1 3 5.0 O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 10.1021/acsmedchemlett.6b00360
171349741 193599 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)cc(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5266730 193599 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)cc(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
85472618 162404 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 491 7 1 4 6.7 Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4164509 162404 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 491 7 1 4 6.7 Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F 10.1021/acsmedchemlett.7b00233
156016929 177830 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)
ChEMBL 540 7 1 7 5.3 COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1 10.1016/j.bmc.2019.115263
CHEMBL4642324 177830 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)
ChEMBL 540 7 1 7 5.3 COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1 10.1016/j.bmc.2019.115263
137659366 159525 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 391 5 1 4 5.1 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4101071 159525 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 391 5 1 4 5.1 Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12 10.1021/acs.jmedchem.7b00210
137638317 156814 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 387 6 1 5 4.4 COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1 10.1021/acs.jmedchem.7b00210
CHEMBL4070273 156814 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 387 6 1 5 4.4 COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1 10.1021/acs.jmedchem.7b00210
171351058 193644 None 0 Human Binding pEC50 = 4.1 4.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 446 8 2 7 3.7 Cc1cc(OCc2nc(N)nc(NCCc3c(C)cccc3C)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5267671 193644 None 0 Human Binding pEC50 = 4.1 4.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 446 8 2 7 3.7 Cc1cc(OCc2nc(N)nc(NCCc3c(C)cccc3C)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
137638318 156826 None 0 Human Binding pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 402 4 1 5 4.4 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 10.1021/acs.jmedchem.7b00210
CHEMBL4070359 156826 None 0 Human Binding pEC50 = 6.1 6.1 - 1
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 402 4 1 5 4.4 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 10.1021/acs.jmedchem.7b00210
127031001 139220 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 242 3 1 1 3.4 CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1 10.1021/acs.jmedchem.5b01962
CHEMBL3786972 139220 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 242 3 1 1 3.4 CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1 10.1021/acs.jmedchem.5b01962
137651153 157296 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 371 6 1 4 4.7 CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4076004 157296 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 371 6 1 4 4.7 CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
67072752 86563 None 0 Human Binding pEC50 = 6.1 6.1 - 1
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 289 4 1 2 3.2 N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 10.1021/ml4000673
CHEMBL2315528 86563 None 0 Human Binding pEC50 = 6.1 6.1 - 1
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 289 4 1 2 3.2 N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 10.1021/ml4000673
137654131 159106 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 416 5 1 4 5.3 COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
CHEMBL4096579 159106 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 416 5 1 4 5.3 COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 10.1021/acs.jmedchem.7b00210
134131620 142519 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 442 7 1 5 4.5 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3890035 142519 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 442 7 1 5 4.5 COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
66562286 90400 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 268 3 1 1 3.2 O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F 10.1021/ml4000673
CHEMBL2386359 90400 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 268 3 1 1 3.2 O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F 10.1021/ml4000673
134153298 152455 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 412 6 1 4 4.8 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3970166 152455 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 412 6 1 4 4.8 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
134131874 144945 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 404 6 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
CHEMBL3909773 144945 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 404 6 1 3 5.6 O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 10.1021/acsmedchemlett.6b00394
171349686 194572 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 466 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5289306 194572 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 466 8 2 7 4.1 Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
171350316 193632 None 0 Human Binding pEC50 = 4.1 4.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 503 9 2 9 3.0 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3N3CCOCC3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5267354 193632 None 0 Human Binding pEC50 = 4.1 4.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 503 9 2 9 3.0 Cc1cc(OCc2nc(N)nc(NCCc3ccccc3N3CCOCC3)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
85472227 162282 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 519 7 1 4 6.8 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4162566 162282 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 519 7 1 4 6.8 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 10.1021/acsmedchemlett.7b00233
66562389 90401 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 286 3 1 1 3.4 O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F 10.1021/ml4000673
CHEMBL2386360 90401 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 286 3 1 1 3.4 O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F 10.1021/ml4000673
134156455 154410 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 394 6 1 5 4.3 Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
CHEMBL3986721 154410 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 394 6 1 5 4.3 Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
137637713 155946 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 369 4 1 4 4.6 Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
CHEMBL4060171 155946 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 369 4 1 4 4.6 Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 10.1021/acs.jmedchem.7b00210
25149901 186792 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 250 3 1 1 3.1 O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 10.1021/ml4000673
CHEMBL488384 186792 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 250 3 1 1 3.1 O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 10.1021/ml4000673
25149901 186792 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 250 3 1 1 3.1 O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 10.1021/acs.jmedchem.5b01962
CHEMBL488384 186792 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 250 3 1 1 3.1 O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 10.1021/acs.jmedchem.5b01962
85472225 162856 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4171724 162856 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 495 7 1 4 6.5 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
16775835 180269 None 1 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 316 3 2 3 3.1 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
CHEMBL4748982 180269 None 1 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 316 3 2 3 3.1 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
134152336 153545 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 408 5 1 5 4.2 Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
CHEMBL3979448 153545 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 408 5 1 5 4.2 Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 10.1021/acsmedchemlett.6b00394
16770747 182277 None 1 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 334 3 2 3 3.2 Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
CHEMBL4782622 182277 None 1 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 334 3 2 3 3.2 Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F 10.1016/j.bmcl.2020.127650
134145700 148839 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 400 7 1 4 5.0 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
CHEMBL3940429 148839 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay
ChEMBL 400 7 1 4 5.0 COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F 10.1021/acsmedchemlett.6b00394
137656733 159678 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 383 4 1 4 4.9 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4102951 159678 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 383 4 1 4 4.9 Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 10.1021/acs.jmedchem.7b00210
171352230 193970 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 8 2 7 3.4 Cc1cc(OCc2nc(N)nc(NCCc3c(F)cccc3F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5275546 193970 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 454 8 2 7 3.4 Cc1cc(OCc2nc(N)nc(NCCc3c(F)cccc3F)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
171356095 194253 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5282108 194253 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 486 8 2 7 4.4 Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3Cl)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
90418333 162750 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 473 8 1 5 5.7 COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4169851 162750 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 473 8 1 5 5.7 COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
71655226 90398 None 0 Human Binding pEC50 = 4.0 4.0 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 251 3 1 2 2.5 O=C(O)CCc1ccc(C#Cc2ccccc2)nc1 10.1021/ml4000673
CHEMBL2386357 90398 None 0 Human Binding pEC50 = 4.0 4.0 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 251 3 1 2 2.5 O=C(O)CCc1ccc(C#Cc2ccccc2)nc1 10.1021/ml4000673
73777174 150542 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
CHEMBL3954140 150542 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
ChEMBL 356 3 1 3 4.4 O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 10.1021/acsmedchemlett.6b00360
171346166 194419 None 0 Human Binding pEC50 = 4.0 4.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 446 8 2 7 3.7 Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)cc3C)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
CHEMBL5285725 194419 None 0 Human Binding pEC50 = 4.0 4.0 - 0
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
ChEMBL 446 8 2 7 3.7 Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)cc3C)n2)cc(N2CCCC2=O)c1 10.1021/acsmedchemlett.2c00160
6483 3886 None 39 Human Binding pEC50 = 6.0 6.0 - 2
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 307 4 1 2 3.3 N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O 10.1021/ml4000673
66553168 3886 None 39 Human Binding pEC50 = 6.0 6.0 - 2
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 307 4 1 2 3.3 N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O 10.1021/ml4000673
CHEMBL2386353 3886 None 39 Human Binding pEC50 = 6.0 6.0 - 2
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 307 4 1 2 3.3 N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O 10.1021/ml4000673
66562386 90404 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 307 3 1 2 3.4 Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
CHEMBL2386363 90404 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay
ChEMBL 307 3 1 2 3.4 Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1 10.1021/ml4000673
127033020 139163 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 256 3 1 1 3.6 O=C(O)CCc1ccc(C#CC2CCCCC2)cc1 10.1021/acs.jmedchem.5b01962
CHEMBL3786418 139163 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay
ChEMBL 256 3 1 1 3.6 O=C(O)CCc1ccc(C#CC2CCCCC2)cc1 10.1021/acs.jmedchem.5b01962
162652317 180427 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 304 7 1 3 3.4 COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4751137 180427 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 304 7 1 3 3.4 COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
162672935 183308 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 332 7 1 4 3.2 COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
CHEMBL4795858 183308 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay
ChEMBL 332 7 1 4 3.2 COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 10.1016/j.bmcl.2020.127650
85472359 162223 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 471 8 1 4 6.3 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
CHEMBL4161536 162223 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 471 8 1 4 6.3 CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 10.1021/acsmedchemlett.7b00233
85472487 162572 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
CHEMBL4167097 162572 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 477 7 1 4 6.4 O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F 10.1021/acsmedchemlett.7b00233
145960576 162246 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 527 8 1 5 6.6 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
CHEMBL4161929 162246 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay
ChEMBL 527 8 1 5 6.6 O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 10.1021/acsmedchemlett.7b00233
137637243 155979 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 343 5 1 4 4.1 O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1 10.1021/acs.jmedchem.7b00210
CHEMBL4060517 155979 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay
ChEMBL 343 5 1 4 4.1 O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1 10.1021/acs.jmedchem.7b00210
134135468 144563 None 0 Mouse Binding pEC50 = 6 6.0 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 389 4 1 3 4.8 O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 10.1021/acsmedchemlett.6b00360
CHEMBL3906716 144563 None 0 Mouse Binding pEC50 = 6 6.0 - 0
Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
ChEMBL 389 4 1 3 4.8 O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 10.1021/acsmedchemlett.6b00360
233085 113086 None 38 Mouse Binding pIC50 = 8.1 8.1 - 0
Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311302 113086 None 38 Mouse Binding pIC50 = 8.1 8.1 - 0
Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.1016/j.bmcl.2014.05.012
233085 113086 None 38 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311302 113086 None 38 Rat Binding pIC50 = 8.1 8.1 - 0
Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.1016/j.bmcl.2014.05.012
233085 113086 None 38 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.1016/j.bmcl.2014.05.012
CHEMBL3311302 113086 None 38 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells
ChEMBL 351 3 1 3 4.2 Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 10.1016/j.bmcl.2014.05.012
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