Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
172463086 196614 None 0 Human Functional pIC50 = 5.9 5.9 4 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 330 7 3 7 1.9 C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5427907 196614 None 0 Human Functional pIC50 = 5.9 5.9 4 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 330 7 3 7 1.9 C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172441907 194981 None 0 Human Functional pIC50 = 5.8 5.8 3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 336 7 3 7 2.6 C[C@H](CO)Nc1nc(SCCC2CCCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5394402 194981 None 0 Human Functional pIC50 = 5.8 5.8 3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 336 7 3 7 2.6 C[C@H](CO)Nc1nc(SCCC2CCCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
163322282 191744 None 3 Human Functional pIC50 = 4.8 4.8 -478 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 6 2 7 3.0 C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2oncc12 10.1016/j.ejmech.2023.115240
CHEMBL5195797 191744 None 3 Human Functional pIC50 = 4.8 4.8 -478 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 6 2 7 3.0 C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2oncc12 10.1016/j.ejmech.2023.115240
172454542 195701 None 0 Human Functional pIC50 = 4.8 4.8 -1 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 7 2 7 2.4 COCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5409317 195701 None 0 Human Functional pIC50 = 4.8 4.8 -1 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 7 2 7 2.4 COCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
145985766 165789 None 0 Human Functional pIC50 = 4.8 4.8 -1862 3
Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay
ChEMBL 504 6 2 6 4.5 NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1 10.1016/j.bmcl.2018.07.042
CHEMBL4245355 165789 None 0 Human Functional pIC50 = 4.8 4.8 -1862 3
Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay
ChEMBL 504 6 2 6 4.5 NC(=O)c1ccc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)cn1 10.1016/j.bmcl.2018.07.042
172465121 196772 None 0 Human Functional pIC50 = 4.7 4.7 -4 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 7 3 7 2.1 OCCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5431899 196772 None 0 Human Functional pIC50 = 4.7 4.7 -4 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 7 3 7 2.1 OCCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172467317 196928 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 308 5 3 7 2.0 C[C@H](CO)Nc1nc(SC2CCCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5435008 196928 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 308 5 3 7 2.0 C[C@H](CO)Nc1nc(SC2CCCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172449533 195622 None 0 Human Functional pIC50 = 5.6 5.6 -5 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 366 6 3 7 2.5 CC(C)(CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5407300 195622 None 0 Human Functional pIC50 = 5.6 5.6 -5 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 366 6 3 7 2.5 CC(C)(CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172445880 195146 None 0 Human Functional pIC50 = 4.6 4.6 -5 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 336 6 3 7 1.4 C[C@H](CO)Nc1nc(OCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5397416 195146 None 0 Human Functional pIC50 = 4.6 4.6 -5 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 336 6 3 7 1.4 C[C@H](CO)Nc1nc(OCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
163322284 190266 None 3 Human Functional pIC50 = 5.6 5.6 -14 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 6 3 7 2.1 C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5173775 190266 None 3 Human Functional pIC50 = 5.6 5.6 -14 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 6 3 7 2.1 C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172454278 196016 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 312 9 3 8 1.1 CCCOCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
CHEMBL5415154 196016 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 312 9 3 8 1.1 CCCOCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
172465276 196906 None 0 Human Functional pIC50 = 6.4 6.4 3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 322 6 3 7 2.2 C[C@H](CO)Nc1nc(SCC2CCCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5434552 196906 None 0 Human Functional pIC50 = 6.4 6.4 3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 322 6 3 7 2.2 C[C@H](CO)Nc1nc(SCC2CCCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
170901566 197174 None 1 Human Functional pIC50 = 6.4 6.4 12 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 310 9 3 7 2.2 CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
CHEMBL5440411 197174 None 1 Human Functional pIC50 = 6.4 6.4 12 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 310 9 3 7 2.2 CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
8497 2737 None 41 Human Functional pIC50 = 5.3 5.3 -977 4
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 397 7 3 7 2.9 CC[C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C 10.1016/j.ejmech.2023.115240
9865554 2737 None 41 Human Functional pIC50 = 5.3 5.3 -977 4
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 397 7 3 7 2.9 CC[C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C 10.1016/j.ejmech.2023.115240
CHEMBL216981 2737 None 41 Human Functional pIC50 = 5.3 5.3 -977 4
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 397 7 3 7 2.9 CC[C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C 10.1016/j.ejmech.2023.115240
172450974 195735 None 0 Human Functional pIC50 = 5.3 5.3 2 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 324 9 3 7 2.5 CC(C)CCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
CHEMBL5409816 195735 None 0 Human Functional pIC50 = 5.3 5.3 2 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 324 9 3 7 2.5 CC(C)CCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
172446176 195522 None 0 Human Functional pIC50 = 5.3 5.3 -28 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 366 7 3 7 2.5 CC[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5405321 195522 None 0 Human Functional pIC50 = 5.3 5.3 -28 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 366 7 3 7 2.5 CC[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172450141 195840 None 0 Human Functional pIC50 = 5.2 5.2 -1 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 355 6 2 7 2.4 OCCSc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5411713 195840 None 0 Human Functional pIC50 = 5.2 5.2 -1 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 355 6 2 7 2.4 OCCSc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172450116 195812 None 0 Human Functional pIC50 = 5.2 5.2 -2 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 308 6 3 7 1.8 C[C@H](CO)Nc1nc(SCC2CCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5411165 195812 None 0 Human Functional pIC50 = 5.2 5.2 -2 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 308 6 3 7 1.8 C[C@H](CO)Nc1nc(SCC2CCCC2)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172461550 196824 None 0 Human Functional pIC50 = 5.2 5.2 -3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 6 3 7 2.1 C[C@@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5432877 196824 None 0 Human Functional pIC50 = 5.2 5.2 -3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 352 6 3 7 2.1 C[C@@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
172455714 196121 None 0 Human Functional pIC50 = 5.2 5.2 -3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 366 7 3 7 2.5 C[C@H](CCO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5417284 196121 None 0 Human Functional pIC50 = 5.2 5.2 -3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 366 7 3 7 2.5 C[C@H](CCO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
136165388 196848 None 17 Human Functional pIC50 = 5.1 5.1 -1 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 475 4 3 7 3.1 Cc1ccc([C@H](NC2=NS(=O)(=O)N=C2Nc2ccc(C)c(C(=O)N(C)C)c2O)C(C)(C)C)o1 10.1016/j.ejmech.2023.115240
CHEMBL5433301 196848 None 17 Human Functional pIC50 = 5.1 5.1 -1 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 475 4 3 7 3.1 Cc1ccc([C@H](NC2=NS(=O)(=O)N=C2Nc2ccc(C)c(C(=O)N(C)C)c2O)C(C)(C)C)o1 10.1016/j.ejmech.2023.115240
172454055 195717 None 0 Human Functional pIC50 = 5.1 5.1 -3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 310 8 3 7 2.1 CCCC(C)CSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
CHEMBL5409489 195717 None 0 Human Functional pIC50 = 5.1 5.1 -3 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 310 8 3 7 2.1 CCCC(C)CSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
172449877 196054 None 0 Human Functional pIC50 = 5.1 5.1 -2 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 338 6 3 7 1.7 OCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
CHEMBL5415857 196054 None 0 Human Functional pIC50 = 5.1 5.1 -2 2
Antagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assayAntagonist activity at CCR7 in human CD4 cells by fluorescence based calcium mobilization assay
ChEMBL 338 6 3 7 1.7 OCCNc1nc(SCc2cccc(F)c2F)nc2[nH]nnc12 10.1016/j.ejmech.2023.115240
134817249 165922 None 19 Human Functional pIC50 = 5.0 5.0 -20892 3
Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay
ChEMBL 504 6 2 6 4.5 NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1 10.1016/j.bmcl.2018.07.042
CHEMBL4248604 165922 None 19 Human Functional pIC50 = 5.0 5.0 -20892 3
Inhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assayInhibition of human CCR7 expressed in CHO cells assessed as decrease in CCL19-induced reduction of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed agonist addition measured after 30 mins by HTRF assay
ChEMBL 504 6 2 6 4.5 NC(=O)c1cc(-c2ccc(S(=O)(=O)[C@H]3CC[C@H](Nc4ccc(C(F)(F)F)cn4)CC3)cc2)ccn1 10.1016/j.bmcl.2018.07.042
8652 845 None 0 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16904643
810 834 None 0 Human Functional pIC50 = 8.4 8.4 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16904643
810 834 None 0 Human Functional pIC50 = 8.4 8.4 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9153236
810 834 None 0 Human Functional pIC50 = 8.4 8.4 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9507024
811 843 None 0 Human Functional pIC50 = 9.3 9.3 12 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9507024


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
183790 3742 None 8 Human Binding pIC50 = 8.9 8.9 - 2
Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/acs.jmedchem.9b01701
783 3742 None 8 Human Binding pIC50 = 8.9 8.9 - 2
Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/acs.jmedchem.9b01701
CHEMBL1178786 3742 None 8 Human Binding pIC50 = 8.9 8.9 - 2
Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)
ChEMBL 495 6 1 2 6.8 Cc1ccc(cc1)c1ccc2c(c1)C=C(CCC2)C(=O)Nc1ccc(cc1)C[N+](C1CCOCC1)(C)C 10.1021/acs.jmedchem.9b01701
170901566 197174 None 1 Human Binding pIC50 = 5.8 5.8 - 0
Competitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysisCompetitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysis
ChEMBL 310 9 3 7 2.2 CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
CHEMBL5440411 197174 None 1 Human Binding pIC50 = 5.8 5.8 - 0
Competitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysisCompetitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysis
ChEMBL 310 9 3 7 2.2 CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1 10.1016/j.ejmech.2023.115240
11285792 879 None 32 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/acs.jmedchem.9b01701
801 879 None 32 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/acs.jmedchem.9b01701
CHEMBL2110727 879 None 32 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/acs.jmedchem.9b01701
DB11758 879 None 32 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of CCR7 (unknown origin)Inhibition of CCR7 (unknown origin)
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/acs.jmedchem.9b01701
810 834 None 0 Human Binding pKd = 10 10.0 39 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10512740
8652 845 None 0 Human Binding pKd = 9.9 9.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10512740
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